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Context. A gravitational wave (GW) passing through an astrometric observer causes periodic shifts of the apparent star positions measured by the observer. For a GW of sufficient amplitude and duration, at a suitable frequency, these shifts might be detected with a Gaia-like astrometric telescope. Aims. This paper is aimed at making a detailed analysis of the effects of GWs on an astrometric soluti
ContextPrimary forests, with little to no direct human impact, can serve as baselines to assess land-use effects. However, most have been converted for other land-uses and the locations and characteristics of the remaining forests are poorly characterized.ObjectivesThis study presents a map of Swedish primary forests, explores their persistence in a managed landscape, and assesses their suitabilit
The impact of amyloid-β (Aβ) accumulation on regional brain atrophy in preclinical Alzheimer’s disease (AD), and its interaction with risk factors like sex and APOE -ε4 carriership, remains unclear. In this study, we examined these associations in a population of older adults without dementia and evaluated the potential of Aβ-PET for risk stratification. We included 1329 participants (56 % female)
Hard-to-heal wounds are a growing human and financial concern, constituting approximately 1–3% of the healthcare budget. Wound care is not a medical specialty and is often not prioritized within healthcare. A large portion of the cost and suffering caused by wounds has the potential to be mediated through improved knowledge and effectivised workflows. One potential way to achieve this is through t
Background: Parkinson's disease and atypical parkinsonism are characterized by motor and non-motor symptoms. As the disease advances, planning for end-of-life (EoL) care becomes increasingly important. However, consensus-based European guidelines for advance care planning and documentation of EoL care preferences for parkinsonism are lacking. Understanding current documentation practices for EoL c
Context. The discovery and characterization of mini-Neptunes hold a potentially crucial impact on planetary formation and evolution theories. Estimating their orbital parameters and atmospheric properties would provide valuable hints to improve formation and atmospheric models. Aims. We present the discovery of two mini-Neptunes near a 2:1 orbital resonance configuration orbiting the K0 star TOI-1
Globally, a substantial number of children experience various forms of parental maltreatment. Child protection agencies work to support these children and prevent further abuse or neglect, often through targeted interventions directed at the parents. Previous research has indicated that social workers may approach male and female perpetrators of maltreatment differently once a case is reported. To
Introduction This study aimed to evaluate the clinical impact of implementing routine emergency computed tomography (eCT) for all patients presenting with suspected acute renal colic at the emergency department (ED). Material and methods We did a retrospective observational study of all patients who underwent eCT for suspected acute renal colic at the ED in Helsingborg between May 9, 2023 and May
INTRODUCTION: Maternal blood pressure (BP) is crucial for the health of both mother and fetus, with long-term implications for the child's health. Studies exploring the link between perfluoroalkyl substances (PFAS) exposure and hypertensive disorders of pregnancy often yield inconsistent results, frequently focusing on a single BP measurement rather than longitudinal measurements. This study chara
Aims: There is current apprehension among some clinicians and conflicting evidence regarding ocular complications in relation to Glucagon-like peptide-1 receptor agonists (GLP-1RAs). We aimed to generate multi-disciplinary, expert-led consensus recommendations relating to ocular complications to facilitate optimum prescribing of GLP-1RAs. Materials and Methods: A modified Delphi was conducted foll
Introduction Major depressive disorder (MDD) is a major global healthcare challenge. This is, in part, due to the lack of treatment response and chronic course of MDD. Such a course of illness is often termed treatment-resistant depression (TRD) and is seen in over one-Third of people with MDD. Reasons for treatment resistance are not well established, nor is the definition of TRD. Duration and se
Objectives Sustained activity of the upper trapezius muscle during work has been linked to the development of neck pain. Women have higher occurrences of neck pain than men, even in the same occupations. This study aimed to investigate sex-specific associations between upper trapezius muscle activity time-related variables and neck pain using a meta-analysis of pooled data. Methods Seven Scandinav
Very-low-field MRI (<100 mT) holds promise for Point-of-Care brain imaging applications, including stroke and multiple sclerosis, with T1 mapping emerging as a key biomarker for brain development and pathology. However, current low-field T1 mapping protocols suffer from long acquisition times and limited multi-site repeatability. This study aimed to improve T1 mapping at 64 mT using a clinically f
Membrane technology has revolutionized protein recovery in the food industry, beginning with whey protein extraction via ultrafiltration. This success led to its application in concentrating animal proteins like blood plasma, fish proteins, and albumen. As the protein shift towards plant-based sources grows, membrane processes now enable the industrial recovery of wheat, sunflower, and rapeseed pr
Popular Abstract in Swedish Många växtarter kan inte kolonisera kalkjordar och det är stora skillnader i artsammansättningen mellan kalkjordar och närliggande surare jordar. Detta beteende kallas ofta för kalkskyende och tycks orsakas av en oförmåga hos dessa växtarter att lösa och ta upp fosfat och järn ur kalkjordar. Kalkjordar innehåller mycket låga halter av järn och fosfat löst i marklösningeMany vascular plant species are unable to colonise calcareous sites, the floristic composition of adjacent limestone and acid silicate soils differing markedly. The inability of these 'calcifuge' species to establish themselves and grow on limestone soil appears to mainly be related to their low capacity for solubilising and absorbing phosphate and/or iron from such soils. Differences between calc
The European Space Agency's Gaia satellite was launched into orbit around L2 in December 2013 with a payload containing 106 large-format scientific CCDs. The primary goal of the mission is to repeatedly obtain high-precision astrometric and photometric measurements of one thousand million stars over the course of five years. The scientific value of the down-linked data, and the operation of the on
The ECL cells in the oxyntic mucosa secrete histamine in response to gastrin, stimulating parietal cells to produce acid. Do they also operate under nervous control? The present study examines histamine mobilization from rat stomach ECL cells in situ in response to acute vagal excitation and to food or gastrin following vagal or sympathetic denervation. Applying the technique of microdialysis, we
Popular Abstract in Swedish Den molekylära processen under vilken DNA-information förs över till RNA-information kallas transkription. Transkription styrs främst i samverkan med många speciella molekyler som kallas transkriptionsfaktorer. Zinkfinger proteiner är en av de vanligast förekommande klasserna av reglerande proteiner i eukaryota celler där de inverkar på en mängd av cellulära aktiviteterThe molecular process under which message in DNA is relayed onto RNA is called transcription, and it accomplished through involvement of so-called transcription factors. Zinc finger proteins are one of the most abundant classes of regulatory proteins in eukaryotic cells where they play central roles in a variety of cellular activities. A classical zinc finger is a small protein motif with a simple
Popular Abstract in Swedish Denna avhandling är uppbyggd kring fyra artiklar som berör reglering av gener i B-celler. B-cellerna är en viktig del av vårt immunförsvar, de sköter produktionen av antikroppar som hjälper till att skydda våra slemhinnor och vårt inre från sjukdomsframkallande bakterier och virus. Kroppens försvar mot sådana patogener består av flera delar, inklusive vår hud och våra sEach Ig V-region has its own upstream promoter and the promoter of a mature Ig gene is thereby selected during the V(D)J recombination process. Upon comparison, it is evident that only one transcription factor binding site, the octamer, is preserved within all promoters. The octamer motif and the binding Oct-proteins are crucial for Ig promoter function, but not sufficient for a high level of tran
The word “desertification” was introduced in 1949 by the French scientist Aubreville in his report “Climats, forêts et désertification de l´Afrique tropicale”. The concept, however, was discussed earlier by European and American scientists in terms of increased sand movements, desiccation, desert and Sahara encroachment and man made deserts. Desertification, at the beginning of last century, mea
