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BACKGROUND: The objective of this study was firstly to develop and evaluate an automated method for the detection of new lesions and changes in bone scan index (BSI) in serial bone scans and secondly to evaluate the prognostic value of the method in a group of patients receiving chemotherapy.METHODS: The automated method for detection of new lesions was evaluated in a group of 266 patients using t

Prior treatment exposure in patients with relapsed/refractory multiple myeloma may affect outcomes with subsequent therapies. We analyzed efficacy and safety according to prior treatment in the phase 3 TOURMALINE-MM1 study of ixazomib-lenalidomide-dexamethasone (ixazomib-Rd) versus placebo-Rd. Patients with relapsed/refractory multiple myeloma received ixazomib-Rd or placebo-Rd. Efficacy and safet

By identifying individuals with low peak bone mass (PBM) at young age, early targeted interventions to reduce future fracture risk could be possible. Peripheral quantitative computed tomography (pQCT) is in many ways superior to the gold standard dual-energy X-ray absorptiometry (DXA), as cortical and trabecular compartments as well as the volumetric density and bone structure can be examined sepa

Using Swedish nationwide registry data, the authors investigated the correlation of genetic and environmental risk factors in the etiology of drug abuse as ascertained from medical and criminal registries by modeling twin and sibling data. Medical drug abuse was defined using public inpatient and outpatient records, while criminal drug abuse was ascertained through legal records. Twin, full and ha

The long-term effects of Basic Body Awareness Therapy (BBAT) in addition to treatment as usual (TAU) were studied in a randomized, controlled design in psychiatric outpatient care. Seventy-seven patients with mood, stress-related somatoform, behavioural or personality disorders were studied at baseline, after a 3-month treatment period and at a 6-month follow-up. The use of psychiatric healthcare

Background and purpose - Little is know about patterns of sick leave in connection with total hip and knee joint replacement (THR and TKR) in patients with osteoarthritis (OA). Patients and methods - Using registers from southern Sweden, we identified hip and knee OA patients aged 40-59 years who had a THR or TKR in the period 2004-2012. Patients who died or started on disability pension were excl

Ibrutinib, a Bruton’s tyrosine kinase inhibitor is approved for relapsed/refractory and del(17p)/TP53 mutated chronic lymphocytic leukemia. Discrepancies between clinical trials and routine healthcare are commonly observed in oncology. Herein we report real-world results for 95 poor prognosis Swedish patients treated with ibrutinib in a compassionate use program. Ninety-five consecutive patients (

Background: The power and influence of the hidden curriculum - culturally situated norms and values - onlearning opportunities is a growing concern in medical education. However, while medical schools producediversity and equal treatment policies, efforts towards surfacing and addressing equal opportunities in theclinical learning environment trail behind.Summary of Work: To better understand how

BACKGROUND: Middle-Eastern immigrants in Sweden are at increased risk for type 2 diabetes (T2D) and poor mental health. Physical activity not only prevents/delays onset of T2D but also shows favorable effects on mental health. However, the effects of a culturally adapted lifestyle intervention on mental health among Middle-Eastern immigrants have not been explored before. We aimed to study the eff

It is well known that high-level exposure to cadmium can cause bone disease such as osteoporosis, osteomalacia and fractures. However, the effect of low-level exposure, as found in the general population (mainly derived from diet and smoking), has only been assessed recently. The aim of this study was to examine if cadmium exposure in the general Swedish population causes other bone changes than d

Two unique Pre-Viking Age ship burials were found from Salme village, Saaremaa Island, eastern Baltic Sea, containing remains of seven men in the smaller and 34 men in the larger ship. According to the archaeological interpretations, these ships belonged to a viking crew possibly from the Stockholm-Mälaren region, eastern Sweden. Geoarchaeological research was conducted in the area to reconstruct

Background: People with substance use disorders (SUD) including patients in opioid substitution treatment (OST) are subject to stigma, and have generally poor health and barriers towards seeking healthcare. Experience of stigma might negatively affect healthcare seeking, but this topic is sparsely investigated. The aim of this study was to explore OST patients’ past and present experiences of subs

The overall goal of this article is to demonstrate a state-of-the-art ultrahigh field (UHF) magnetic resonance (MR) protocol of the brain at 7.0 Tesla in multiple sclerosis (MS) patients. MS is a chronic inflammatory, demyelinating, neurodegenerative disease that is characterized by white and gray matter lesions. Detection of spatially and temporally disseminated T2-hyperintense lesions by the use

Bilismen orsakar en mängd problem i våra städer. Det handlar dels om negativa effekter på människors hälsa på grund av skadliga partikelutsläpp, buller, trafikolyckor och stillasittande, dels om platsen den tar i anspråk vilket leder till trängsel och att värdefull mark tas i besittning av väginfrastruktur och parkeringsplatser. I ett större perspektiv bidrar biltrafiken även till utsläpp av växthTraffic accumulated by cars is responsible for considerable problems in our cities. The problem is partly about the negative effects on human health due to harmful particulate emissions, noise, traffic accidents and sedentary lifestyles, partly about the space it occupies, which leads to congestion, and the fact that valuable land is taken up by road infrastructure and parking lots. In a bigger pe

OBJECTIVE: HER2/ErbB2 is a member of the epidermal growth factor receptor family. It is widely used as a tumor marker, but it also has recently been associated with insulin resistance. Both ErbB2 and diabetes have been associated with cancer; however, the relationship between ErbB2 and diabetes has not been well explored. The aim of this population-based cohort study was to assess the association

Background: Recurrent severe Dupuytren contracture of the small finger's proximal interphalangeal (PIP) joint is a difficult problem. Further surgery carries high risk of complications and poor outcome. Patients are often offered finger amputation. We have devised a novel surgical procedure consisting of middle phalanx monoblock resection and ligament reconstruction to create a new functioning int

Context. The abundance ratio N/O is a useful tool to study the interplay of galactic processes, for example star formation e ciency, timescale of infall, and outflow loading factor. Aims. We aim to trace log(N/O) versus [Fe/H] in the Milky Way and to compare this ratio with a set of chemical evolution models to understand the role of infall, outflow, and star formation e ciency in the building up

Aims and objectives. To present data on Swedish ICU nurses’ attitudes to brain death and organ donation and to test a questionnaire designed to explore these issues in terms of validity and reliability.Background. Previous studies have identified various barriers to organ donation. The single most important factor was the attitude of ICU staff.Design. A 34‐item instrument was developed to explore

Background: Autoimmune (type 1) diabetes (T1D) is a frequent chronic disease in children and adolescents globally. Gestational enterovirus (EV) infections have been associated with an increased risk for T1D in the offspring. We test the hypothesis that EV infections during the first trimester were associated with beta cell autoantibodies in mothers of children who developed islet autoantibodies be

This paper presents a method to grasp objects that cannot be picked directly from a table, using a soft, underactuated hand. These grasps are achieved by dragging the object to the edge of a table, and grasping it from the protruding part, performing so-called slide-to-edge grasps. This type of approach, which uses the environment to facilitate the grasp, is named Environmental Constraint Exploita