Filtyp
Mixed phenotype acute leukemias (MPALs) represent a rare subgroup of acute leukemias with a poor prognosis. Proper diagnosis and classification of MPAL is extremely important for patients' outcome. Morphology and flow cytometry recognize two types of MPAL: the “bilineal” MPAL with the coexistence of two blast populations of different lineage and truly “biphenotypic” MPAL coexpressing markers of mo
From the Scandinavian Sarcoma Group Register, information on 1,224 surgically-treated patients with soft tissue sarcoma (STS) of the extremity or trunk wall, diagnosed between 1987 and 1995, was collected. 205 patients, one third of whom were referred to a center with a local recurrence, had a total of 284 local recurrences. This analysis describes the treatment for these local recurrences, compli
Transformation, transition and regime shift are increasingly applied concepts in the academic literature to describe changes in society and the environment. Ecosystem services represent one framework that includes the implicit aim of supporting transformation towards a more sustainable system. Nevertheless, knowledge and systematic reviews on the use of these concepts within ecosystem services res
Vector-boson scattering processes are of great importance for the current run-II and future runs of the Large Hadron Collider. The presence of triple and quartic gauge couplings in the process gives access to the gauge sector of the Standard Model (SM) and possible new-physics contributions there. To test any new-physics hypothesis, sound knowledge of the SM contributions is necessary, with a prec
Pulmonary sarcoidosis was studied with respect to lung mechanical properties and to the influence of these on lung volumes. Sixty six patients, with histological support for the diagnosis of sarcoidosis, and radiological signs of pulmonary involvement, i.e. stage II or III, were studied. The static pressure/volume (P/V) curves showed that the static elastic recoil pressure (PelL) tended to be incr
The Precautionary Principle is both celebrated and criticized. It has become an important principle for decision making, but it is also subject to criticism. One problem that is often pointed out with the principle is that is not clear what it actually says and how to use it. I have taken on this problem by performing an analysis of some of the most influential formulations of the principle in an
South-central Sweden is home to a number of small, inactive inland dune fields formed on former glaciofluvialdeltas. A characteristic of these dune fields is the generally transverse shape of the dunes, in stark contrast to therest of Sweden where parabolic dunes are the most common type.One of these dune fields is Bonäsheden in the county of Dalarna. It is the largest continuous dune field in Swe
Duplicate, bilateral structures of individual animals are usually symmetrical. In cases where such structures are asymmetrical, the degree of asymmetry may indicate the propensity of an individual to stray from the genetically programmed outcome during the development of the structure. Asymmetries have recently been assumed to constitute an honest signal of male quality and, as such, a cue for fem
As it is well known, one of the keys to improve traffic performance of two lane rural roads with high traffic volumes is to provide passing sections. However, providing a long segment in which the passing maneuver is allowed, is not always feasible, especially when suburban areas are considered. The retrofitting of some road sections by adding a passing relief lane can improve traffic performance
Absence epilepsy (AE) is classified as a genetic generalized epilepsies. WAG/Rij strain of rats are regarded one of the most validated models of absence epilepsy. Studies point out the existence of hyperexcitable focus in somatosensory cortex of these rats, which has been attributed to the deficits in the GABAergic system. In the current study, we studied the changes of calcium binding proteins (C
Treated bamboo can be made into large, durable structural elements which have the potential to become a transformative large-scale building material, but the fracture behaviour which determines their ultimate strength in various loading scenarios has not been studied. Laminated bamboo is a promising structural engineered bamboo material, and is generally made from bamboo treated to improve its dur
Popular Abstract in Swedish Den här avhandlingen handlar om interaktion mellan två ytor (t.ex. fibrer, lerpartiklar eller proteiner) i en vattenlösning med motjoner, salt och/eller polyelektrolyter. Polyelektrolyter är laddade polymerer. Avhandlingen är fokuserad på elektrostatisk växelverkan och interaktionerna har undersöks med hjälp av Monte Carlo-simuleringar. De kvalitativa resultaten har oftThe interaction between two colloids with grafted polyelectrolytes in aqueous solution is studied within the primitive model by Monte Carlo simulations. For neutral colloids with grafted polyelectrolytes and in absence of salt the interaction is strongly repulsive in absence of salt. The interaction depends on the extension of the polyelectrolytes from the surfaces and the interaction is derived a
The main structural component of connective tissues is fibrillar, cross-linked collagen whose fibrillogenesis can be modulated by Small Leucine-Rich Proteins/Proteoglycans (SLRPs). Not all SLRPs’ effects on collagen and extracellular matrix in vivo have been elucidated; one of the less investigated SLRPs is asporin. Here we describe the successful generation of an Aspn-/- mouse model and the inves
Fluorescence-based detection assays play an essential role in the life sciences and medicine. To offer better detection sensitivity and lower limits of detection (LOD), there is a growing need for novel platforms with an improved readout capacity. In this context, substrates containing semiconductor nanowires may offer significant advantages, due to their proven light-emission enhancing, waveguidi
The northernmost population of Acer campestre L. has its distribution in southern Sweden and consists of just 36 individuals. This particular remnant is considered critically endangered (CE) although the species spreads rapidly as potentially invasive gene pools escaped from gardens and urban plantations. The issue to distinguish between indigenous and introduced gene pools is urgent, since indivi
In response to the stringent emission regulations, artificial neural network (ANN) coupled with genetic algorithm (GA) is employed to optimize a novel internal combustion engine strategy named direct dual fuel stratification (DDFS). An enhanced ANN model is introduced to improve the accuracy and stability of predictions. Compared to the conventional computational fluid dynamics (CFD)-GA optimizati
We propose a modern approach to assist clinicians to recognize and diagnose inborn errors of metabolism (IEMs) in adolescents and adults that present with a movement disorder. IEMs presenting in adults are still largely unexplored. These disorders receive little attention in neurological training and daily practice, and are considered complicated by many neurologists. Adult-onset presentations of
The boreal forest is among the largest terrestrial biomes on earth, storing more carbon (C) than the atmosphere. Due to rapid climatic warming and enhanced human development, the boreal region may have begun transitioning from a net C sink to a net source. This raises serious concern that old biogenic soil C can be re-introduced into the modern C cycle in near future. Combining bio-decay experimen
Nitrogenase is the only enzyme that can cleave the triple bond in N2, making nitrogen available to plants (although the enzyme itself is strictly microbial). It has been studied extensively with both experimental and computational methods, but many details of the reaction mechanism are still unclear. X-ray crystallography is the main source of structural information for biomacromolecules, but it h
