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Swedish concrete dams are designed and assessed based on deterministic design using safety factors. The combination of increasing age, new methods for calculation of design floods and increasing demands by society to ensure a high level of safety, has resulted in upgrading and rebuilding needs for dams. When safety is re-evaluated it is important that evaluation is based on modern safety concepts.
This paper presents an analysis of the point-spread functions (PSFs),which may be expected in the so-called improved seeing limited mode forthe Euro50 (Extremely large telescope with a 50 m aperture). This modecomprises adaptive control of the deformable secondary mirror of theaplanatic Gregorian telescope configuration using guide stars in a widefield. I may result in efficient compensation of tu
Objective: To study reproduction in a representative group of anorexia nervosa (AN) cases. Method: Fifty-one adolescent-onset AN cases (48 women; three men), originally recruited after community screening, and 51 matched comparison cases (COMP) were interviewed 18 years after AN onset at a mean age of 32 years, regarding pregnancies and early development of the children. Results: The result
Background: Low-dose rate brachytherapy (LDR-BT) has been used in Sweden for more than a decade for treatment of low-risk prostate cancer. This study presents the outcome for patients treated with LDR-BT at a single institution with focus on the association between dose and biochemical failure-free survival (BFFS). Methods: In total 195 patients were treated with LDR-BT between 2004 and 2008. The
Affective forecasting is an ability that allows the prediction of the hedonic outcome of never-before experienced situations, by mentally recombining elements of prior experiences into possible scenarios, and pre-experiencing what these might feel like. It has been hypothesised that this ability is uniquely human. For example, given prior experience with the ingredients, but in the absence of dire
One of the largest challenges of computational chemistry is calculation of accurate free energies for the binding of a small molecule to a biological macromolecule, which has immense implications in drug development. It is well-known that standard molecular-mechanics force fields used in most such calculations have a limited accuracy. Therefore, there has been a great interest in improving the est
We investigate the prospects for the capture of the proposed Planet 9 from other stars in the Sun's birth cluster. Any capture scenario must satisfy three conditions: the encounter must be more distant than ∼150 au to avoid perturbing the Kuiper belt; the other star must have a wide-orbit planet (a ≳ 100 au); the planet must be captured on to an appropriate orbit to sculpt the orbital distribution
The main purpose of this Thesis is the experimental characterization of the electronic and geometric structures of objects called clusters. A cluster consists of a finite group of bound atoms or molecules. Due to its finite size, it may present completely different properties than those of the isolated atom and the bulk. The clusters studied in this work are constituted by rare-gas atoms, organic
Using focus group interviews, this paper studies the way young people in Sweden employed social media to discuss and mobilise during the on-going European refugee crisis, with a special focus on peer pressure, social interaction and connective action.In 2015, an unprecedented influx of refugees, predominantly from Syria, Iraq, and Afghanistan, entered Europe on foot and in dinghies. The refugee cr
Mint/X11 is one of the four neuronal trafficking adaptors that interact with amyloid precursor protein (APP) and are linked with its cleavage to generate β-amyloid peptide, a key player in the pathology of Alzheimer's disease. How APP switches between adaptors at different stages of the secretory pathway is poorly understood. Here, we show that tyrosine phosphorylation of Mint1 regulates the desti
Aim: There have been few studies on long-term electroretinographic findings in patients with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD). This study correlated long-term electroretinographic findings with age, metabolic control and clinical symptoms. Methods: We examined 12 Swedish patients with LCHADD. Visual acuity testing, fundus examinations, optical coherence tomography and
210Pb is a radioactive lead isotope present in the environment as member of the 238U decay chain. Since it is a relatively long-lived radionuclide (T1/2 = 22.2 years), its analysis is of interest in radiation protection and the geochronology of sediments and artwork. Here, we present a method for analysing 210Pb using plastic scintillation resins (PSresins) packaged in solid-phase extraction colu
Heavy quarkonia are observed to be suppressed in relativistic heavy-ion collisions relative to their production in p + p collisions scaled by the number of binary collisions. In order to determine if this suppression is related to color screening of these states in the produced medium, one needs to account for other nuclear modifications including those in cold nuclear matter. In this paper, we pr
Background and purpose The Hansson Twin Hook (HTH) is an alternative to the lag screw in the treatment of trochanteric fractures. In osteoporotic bone, mechanical tests have indicated that the HTH has better fixation properties than the lag screw. We evaluated the fixation stability of the HTH in a large series of elderly patients with trochanteric fractures. Many surgeons were involved in assessm
A novel method for QRST cancellation during atrial fibrillation (AF) is introduced for use in recordings with two or more leads. The method is based on an echo state neural network which estimates the time-varying, nonlinear transfer function between two leads, one lead with atrial activity and another lead without, for the purpose of canceling ventricular activity. The network has different sets
Safe water supply is one of the important Millennium Goals. For development of market water supply services, the willingness of consumers to pay is essential. The consumers’ willingness to pay (WTP) for piped water supply using the contingent valuation (CV) method with different starting point bids was investigated for the Pavlodar Region, Kazakhstan. The results showed that households with access
Feedbacks mechanisms are essential components of our climate system, as they either increase or decrease changes in climate-related quantities in the presence of external forcings. In this work, we provide the first quantitative estimate regarding the terrestrial climate feedback loop connecting the increasing atmospheric carbon dioxide concentration, changes in gross primary production (GPP) asso
To investigate if the Swedish entry rules for pets to prevent the introduction of Echinococcus multilocularis (EM) are proportional (i.e. that their costs do not exceed the value of their benefits), a dichotomous-choice contingent valuation study was conducted. The study was performed before the first case of EM was detected in Sweden in February 2011. About 5000, randomly selected, Swedish citize
In sustainability research and elsewhere the notion of resilience is attracting growing interest and causing heated debate. Those focusing on resilience often emphasize its potential to bridge, integrate, and unify disciplines. This paper attempts to evaluate these claims. Resilience is investigated as it appears in several fields, including materials science, psychology, ecology, and sustainabili
The effects of wood ash application on soil microbial processes were investigated in three drained forested peatlands, which differed in nutrient status and time since application. Measured variables included the concentrations of soil elements and phospholipid fatty acids (PLFAs), net nitrogen (N) mineralization, nitrification and denitrification enzyme activity, potential methane (CH(4)) oxidati
