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How colour polymorphisms are maintained in natural populations constitutes a key subject of study for evolutionary ecologists. One of the mechanisms that has been put forward to explain this phenomenon is negative frequency-dependent selection, which can be caused by different mechanisms. Among these mechanisms is mate choice, or the selection as a potential mate of the rare or dissimilar colour m
Viruses compete with each other for limited cellular resources, and some deliver defense mechanisms that protect the host from competing genetic parasites 1. PARIS is a defense system, often encoded in viral genomes, that is composed of a 55 kDa ABC ATPase (AriA) and a 35 kDa TOPRIM nuclease (AriB) 2. However, the mechanism by which AriA and AriB function in phage defense is unknown. Here we show
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a heterogenous autoimmune disease. While traditionally stratified into two conditions, granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), the subclassification of ANCA-associated vasculitis is subject to continued debate. Here we aim to identify phenotypically distinct subgroups and develop a da
We usually mean what we say, but sometimes we do not. When I ironically utter ‘What lovely weather’ on a rainy day, or mistakenly utter ‘Jim is a barn door’ instead of ‘Jim is a darn bore’, I say one thing and mean another. However, although utterances like these are not uncommon, they are greatly overshadowed by the volume of humdrum utterances of ‘There is wine in the fridge’ or ‘I really like n
The use and significance of timber structures are on the rise, especially thanks to crosslaminated timber (CLT). This engineered wood product is manufactured by stacking multiple layers of wood lamellae, each oriented perpendicularly to the one below it, and then bonding them with adhesives to form a floor or wall panel. Timber, as a building material, presents potential environmental benefits ove
Popular Abstract in Swedish Översvämningar i städer ökar på grund av ökad urbanisering samt klimatförändringar och klimatvariabilitet. Denna avhandling presenterar effekterna av klimatförändringar och intensiv nederbörd i städer samt handhavandet av översvämning i urban områden i Mumbai, Indien och i Skåne samt Göteborg. En rad statistiska och analytiska verktyg har tillämpats för att studera nedeFlooding in urban basins is intensifying due to increasing urbanization and climate change and variability. This thesis presents how the effects of climate change and high-intensive rainfall on the urban drainage system and management of flooding in urban areas of were studied in Mumbai, India and Southern Sweden, including Skåne and Gothenburg. Various statistical and analytical tools were applie
Abstract: Recently, a crystal structure of V-nitrogenase was presented, showing that one of the µ2 sulphide ions in the active site (S2B) is replaced by a lighter atom, suggested to be NH or NH2, i.e. representing a reaction intermediate. Moreover, a sulphur atom is found 7 Å from the S2B site, suggested to represent a storage site for this ion when it is displaced. We have re-evaluated this struc
Sexual selection has been suggested to accelerate local adaptation and promote evolutionary rescue through several ecological and geneticmechanisms. Condition-dependent sexual selection has mainly been studied in laboratory settings, while data from natural populations are lacking. One ecological factor that can cause condition-dependent sexual selection is parasitism. Here, we quantified ectopara
Applying blockchain technology for information sharing in supply chain is driven by many factors, but developing trust is one of the most proposed. However, trust is a multidimensional, intangible concept without an agreed-upon definition. Whereas some argue that trust is the main driver of blockchain technology, others have found a negative relationship. This study focuses on how applying blockch
In social dilemmas punishment costs resources, not just from the one who is punished but often also from the punisher and society. Reciprocity on the other side is known to lead to cooperation without the costs of punishment. The questions at hand are whether punishment brings advantages besides its costs, and how its negative side-effects can be reduced to a minimum in an environment populated by
The curiosity of how the built environment, implicitly and explicitly, affects how citizens and users make choices in their everyday life related to climate change is on the rise. If there is a nicely designed bike lane, the choice to bike to work is much more easily taken than if the only option is a densely trafficked road. But which responsibility does the built environment have for citizens to
Two hole conductor materials, spiro-OMeTAD and P3HT, were compared in solid-state dye-sensitized solar cells. Two organic dyes containing one anchor unit (D35) or two anchor units (M3) were used in the comparison. Absorbed photon to current conversion efficiency close to unity was obtained for the devices with spiro-OMeTAD. Energy conversion efficiencies of 4.7% and 4.9% were measured for the devi
A novel sliding vane rotary compressor with a rotating cylinder is proposed in this paper. The sliding vane dynamics analysis reveals that, compared with the traditional compressor, the friction loss at the sliding vane tips and between rotor and cylinder can be reduced to 0.25% and 10.23%. To numerically investigate the internal flow mechanism, a reliable three-dimensional simulation method is de
Carbohydrate foods differ considerably in their effects on postprandial glucose and insulin responses. Qualitative differences among starchy foods are particularly intriguing because of the dominance of starch in human diets. This paper focuses on food properties in cereal (eg, pasta, bread, Arepas, and porridge) and legume products (eg, red kidney beans and lentils) that affect metabolic response
Amyloid plaques, a well-known hallmark of Alzheimer's disease (AD), are formed by aggregated β-amyloid (Aβ). The cellular prion protein (PrPc) accumulates concomitantly with Aβ in amyloid plaques. One type of amyloid plaque, classified as a neuritic plaque, is composed of an amyloid core and surrounding dystrophic neurites. PrPc immunoreactivity reminiscent of dystrophic neurites is observed in ne
Phosphohydroxylysinuria has been described in two patients with neurological symptoms, but the deficient enzyme or mutated gene has never been identified. In the present work, we tested the hypothesis that this condition is due to mutations in the AGXT2L2 gene, recently shown to encode phosphohydroxylysine phospholyase. DNA analysis from a third patient, without neurological symptoms, but with an
Phosphorylation is one of the most abundant types of post-translational modifications of intrinsically disordered proteins (IDPs). This study examines the conformational changes in the 15-residue-long N-terminal fragment of the IDP statherin upon phosphorylation, using computer simulations with two different force fields: AMBER ff99SB-ILDN and CHARMM36m. The results from the simulations are compar
The concluding chapter first summarizes some of the volume’s main results along the four evaluative themes. In terms of coherence and management, the three policy fields under scrutiny – renewable energy, fossil fuel subsidy reform and carbon pricing – are roughly marked by coordination, rather than competition or outright harmony. Regarding legitimacy, the specializations and work backgrounds of
This study had two aims: first to describe, using both descriptive statistics and quantitative content analysis, the noise environment in an ICU patient room over one day, a patient's physical status during the same day and early signs of ICU delirium; second, to describe, using qualitative content analysis, patients' recall of the noise environment in the ICU patient room. The final study group c
