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Early detection of Alzheimer's disease is essential to develop preventive treatment strategies. Detectible change in brain volume emerges relatively late in the pathogenic progression of disease, but microstructural changes caused by early neuropathology may cause subtle changes in the MR signal, quantifiable using texture analysis. Texture analysis quantifies spatial patterns in an image, such as
BACKGROUND: Knowing whether interventions addressing everyday life as a whole can affect work readiness for people with severe mental health issues would be important for how to develop support. OBJECTIVE: To compare two groups of people with mental health problems, receiving either of two types of 16-week activity-based interventions, Balancing Everyday Life (BEL) or Care as Usual (CAU), regardin
Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain further insights in resting heart rate biology and its clinical consequences. A genome-wide meta-analysis of 100 studies in up to 835,465 individuals reveals
Child participation, mandating that children should be able to impact the laws,policies, and programmes that affect them, is a core child rights principle. However, if children’s ideas should be taken seriously, it requires a radically open-minded and adaptable attitude of the adults whose responsibility it is to implement these laws, policies, and programmes. Such an attitude is difficult to “mai
Ethylene is one of the most important products in the emissions-intensive petrochemical industry. Decarbonizing the ethylene industry is thus important for achieving global carbon neutrality. This study is the first to explore future long-term zero-emissions production pathways for the ethylene industry in China, the world's biggest ethylene producer. An optimization model was built in the context
Background The popularity of tattoos has increased dramatically over the last few decades. Tattoo ink often contains carcinogenic chemicals, e.g., primary aromatic amines, polycyclic aromatic hydrocarbons, and metals. The tattooing process invokes an immunologic response that causes translocation of tattoo ink from the injection site. Deposition of tattoo pigment in lymph nodes has been confirmed
Objective: Subsets of CD21−/low memory B cells (MBCs), including double-negative (DN, CD27−IgD−) and Tbet+CD11c+ cells, are expanded in chronic inflammatory diseases. In rheumatoid arthritis (RA), CD21−/low MBCs correlate with joint destruction. However, whether this is due to the Tbet+CD11c+ subset, its function and pathogenic contribution to RA are unknown. This study aims to investigate the ass
Light emitting diodes (LEDs) have become the most efficient artificial lighting source. Their application is found in general indoor and outdoor lighting, headlights in automobiles, and displays whether it be TVs, laptops, mobile phones or smart watches. This technology is enabled by III-V semiconductors. Standard LEDs are comprised of stacked layers where the active region in the form of multi qu
Objective: Secundum atrial septal defect (ASD II) is a common congenital heart defect, and interatrial communications among preterm children is even more common. The objective of this study was to calculate the incidence of ASD II in children, with assessment to gestational age at birth. Further, to assess maternal, prenatal and postnatal risk factors associated with ASD II among children of diffe
Background: Timely and safe elective health care facilitates return to normal activities for patients and prevents emergency admissions. Surgery is a cornerstone of elective care and relies on complex pathways. This study aimed to take a whole-system approach to evaluating access to and quality of elective health care globally, using inguinal hernia as a tracer condition. Methods: This was a prosp
Backgrounds: Cognitive problems are common symptoms among individuals with stress-related exhaustion. It is still unknown whether these individuals are at a higher risk of developing dementia later. This study aims to examine the relationship between midlife stress-related exhaustion and dementia incidence. Methods: A population sample of 777 women (aged 38, 46, 50 and 54 years) without dementia a
Aim: The analyses here reported aim to compare the screening performance of digital tomosynthesis (DBT) versus mammography (DM). Methods: MAITA is a consortium of four Italian trials, REtomo, Proteus, Impeto, and MAITA trial. The trials adopted a two-arm randomised design comparing DBT plus DM (REtomo and Proteus) or synthetic-2D (Impeto and MAITA trial) versus DM; multiple vendors were included.
Atmospheric inversions have been used for the past two decades to derive large-scale constraints on the sources and sinks of CO2 into the atmosphere. The development of dense in situ surface observation networks, such as ICOS in Europe, enables in theory inversions at a resolution close to the country scale in Europe. This has led to the development of many regional inversion systems capable of as
Purpose: Breast cancer is one of the most common cancer forms in women and it is often detected by screening. However, women with drug use disorders (DUD) are less likely to be reached by screening programs. In this study, we aimed to investigate breast cancer incidence, mortality and stage at time of diagnosis among women with DUD compared to the general female population in Sweden. Methods: We p
Vanuatu is one of the most hazard prone nations in the world and frequently tops the World Risk Report as the nation with the highest overall disaster risk. The devastation wrought by category 5 cyclone Pam (2015), the El Niño drought (2015/16), and volcanic eruptions in Ambae (2018), are but a few recent examples of disasters which have disrupted livelihoods and curtailed development. The Vanuatu
Objective: There is a paucity of data regarding health care costs associated with damage accrual in systemic lupus erythematosus. The present study was undertaken to describe costs associated with damage states across the disease course using multistate modeling. Methods: Patients from 33 centers in 11 countries were enrolled in the Systemic Lupus International Collaborating Clinics (SLICC) incept
We present results from the Agricultural Model Intercomparison and Improvement Project (AgMIP) Global Gridded Crop Model Intercomparison (GGCMI) Phase I, which aligned 14 global gridded crop models (GGCMs) and 11 climatic forcing datasets (CFDs) in order to understand how the selection of climate data affects simulated historical crop productivity of maize, wheat, rice and soybean. Results show th
Populärvetenskaplig sammanfattningEn stor del av världens energikällor är baserade på förbränning och kan återfinnas i allt från bilar och båtar som drivs av förbränningsmotorer till gasturbiner och kraftverk som används till elproduktion. Den centrala biten inom förbränning är en kemisk omvandling av bränslet då det reagerar med syre till att bilda de två huvudsakliga produkterna, vatten och koldAbstractThe work presented in this thesis is mainly focused on the development andapplication of infrared laser-induced grating techniques in order to measure the gasphase temperature and species concentrations in reactive flows. The two techniquesused for this purpose are laser-induced grating spectroscopy (LIGS) and degeneratefour-wave mixing (DFWM). Their coherent nature allows to perform laser
The leaf volatiles emitted from four nonhost tree species of lps typographus, i.e. Betula pendula, B. pubescens, Populus tremula, and Sambucus nigra, were collected outdoors by headspace sampling in situ and analyzed by GC-MS. Three major classes of compounds, aliphatics [mainly green-leaf volatiles (GLVs)], monoterpenes, and sesquiterpenes, existed in all the deciduous tree species investigated.
Background: The purpose of this study was to examine the occurrence of cerebral infarction (ischemic stroke), in a large combined cohort of patients with anterior skull base meningiomas, pituitary adenomas and craniopharyngiomas, after fractionated stereotactic radiation therapy (FSRT). Material and Methods: All patients, 18 years and older, with anterior skull base meningiomas, pituitary adenomas
