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Popular Abstract in Swedish Cancerförekomst i familjen är en riskfaktor för flera vanliga cancerformer. Såväl ärftlig (hereditär) som icke-ärftlig (sporadisk) cancer är resultatet av en ansamling av förändringar (mutationer) i gener vars normala funktion är att reglera cellernas delning, tillväxt och mognad. Vid ärftlig cancer finns den första erforderliga mutationen i kroppenThis thesis focuses on one of the most common types of hereditary cancer, hereditary nonpolyposis colorectal cancer (HNPCC). This syndrome is characterized by an autosomal dominant inheritance, an increased risk for several types of cancer (especially cancer of the colorectum, small bowel, endometrium, ovary and urinary tract), early age at diagnosis, and frequent development of multiple primary m

Popular Abstract in Swedish Lokal läkemedelsstatistik – ett verktyg för att identifiera problemområden och att bedöma effekter av information och utbildning om läkemedel. Det finns behov att studera läkemedelsförskrivning och läkemedelsanvändning och dessas samband med och effekter på hälsa, sjuklighet och överdödlighet. Det är också önskvärt att kunna använda individdata. I Sverige är det i allmAims: 1) To assess if drug sales data indicate differences in morbidity, mortality, socio-economic conditions and deviating prescribing habits among physicians; 2) to identify areas for educational interventions and to analyse changes in prescribing after educational activities. In addition, an effort was made to estimate differences between pharmacy sales and purchases by the population, and the

In the paper, we consider the problem of routing and bandwidth allocation in networks that support elastic traffic. We assume that the bandwidth demand between each source-destination (S-D) pair is specified in terms of a minimum and maximum value, and a set of flows between each S-D pair is allowed to realize these demands. (We say that a set of flows realizes the demand associated with an S-D pa

Continuity of care is one of the core values of family medicine and both patients and doctors consider it a vital aspect of the care of patients with chronic diseases. In 2009 a national health care reform was implemented in primary care in Sweden. This study compared the longitudinal continuity of care in primary care before and after this reform in 7121 adult diabetes patients living in Malmö. O

This paper addresses an important but so far neglected episode in the post-1949 history of China – the impact of the so-called 'Cultural Revolution' on the country's ethnic minority populations. Specifically, it attempts to deal with the movement as it unfolded in the province of Yunnan where, at one stage, it became an attempt by a political leadership in the provincial capital, dominated by mili

Control methods are being used increasingly for uncertainty management and QoS in modern web server systems. Previous approaches have suggested combined feed-forward and feedback control strategies, using queuing theory for feed-forward delay prediction. While queuing theory allows one to predict delay as a function of arrival and service rates, the prediction applies only to long-term averages, a

In the present study, the turbulent heat transfer and fiction in a square duct roughened by continuous and truncated ribs on one wall has been investigated experimentally. The ribs are oriented transversely to the main stream in a periodic arrangement. For both cases, the rib height-to-hydraulic diameter ratio is 0.15, the rib pitch-to-height ratio is fixed at 12, and the Reynolds number varies fr

In this paper, we studied the adsorption at emulsion droplets of potato starch, which was hydrophobically modified with octenyl succinate anhydride (OSA), a surface active macromolecule containing ultrahigh molar mass components. The results show that the substance works as an efficient emulsifier and that it can in some cases generate high surface loads (10 mg/m(2)). The results can be explained

To determine which nuclei may exhibit shape isomerism, we use a well-benchmarked macroscopic-microscopic model to calculate potential-energy surfaces as functions of spheroidal (epsilon(2)), hexadecapole (epsilon(4)), and axial-asymmetry (gamma) shape coordinates for 7206 nuclei from A=31 to A=290. We analyze these and identify the deformations and energies of all minima deeper than 0.2 MeV. These

Semiotic development involves the development of at least two different kinds of meaning: intersubjective and representational. By attending to these two kinds of meaning we are able to predict one of the major transitions in early childhood: the transition to reference. From a dynamic systems perspective we track essential developments which, when all have reached critical values, prompt the tran

We argue that our common diseases should not necessarily be taken as a sign of physiological error. Regulatory networks developed by evolutionary forces to support reproductive fitness happen to include disease as a side-effect. For example, inflammatory and autoimmune diseases are secondary to a strong defence against infections. An evolutionary perspective can help us understand why many drugs t

Four different elastic models for sheathing-to-framing connections are presented and evaluated on asingle connection level and on a shear wall level. Since the models are elastic in their nature they aresuitable mainly for cases where the sheathing-to-framing connections are subjected to monotonicallyincreasing displacements. Of the four models one is uncoupled and the others are coupled with r

In the past years, research on military applications of neuroscience has grown in sophistication. We may expect that future neuroweapons will be advertised as resting on the most objective form of human cognition, leading to greater accuracy in targeting and better compliance with the law than traditional weapons. Are states using weapon systems that draw on neuroscience capable of applying IHL to

Ten to fifteen percent of infertile men are azoospermic, and sixty percent of these men have been classified as having non-obstructive azoospermia (NOA). NOA results from testicular failure, and one of the causes of this is the presence of varicocele. Varicocele is observed in 5-10 % of men with NOA. This review discusses the impact of varicocele repair on semen quality and pregnancy rate among me

Intelligent transport information systems (TIS) are one of the most rapidly emerging applications of wireless vehicular communications using DSRC/WAVE technology. A core function in a TIS is the estimation of traffic density using beacons transmitted by individual vehicles, subsequently used for purposes such as traffic light control or incident detection. In this paper, we conduct an in-depth stu

Since software development is of a dynamic nature, the impact analysis is an inevitable work task. Traceability is known as one factor that supports this task, and several researchers have proposed traceability recovery tools to propose trace links in an existing system. However, these semi-automatic tools have not yet proven useful in industrial applications. Based on an established automation mo

Self-organization in anisotropic colloidal suspensions leads to a fascinating range of crystal and liquid crystal phases induced by shape alone. Simulations predict the phase behaviour of a plethora of shapes while experimental realization often lags behind. Here, we present the experimental phase behaviour of superball particles with a shape in between that of a sphere and a cube. In particular,

The determination of |Vus| from kaon semileptonic decays requires the value of the form factor f+(q2 = 0) which can be calculated precisely on the lattice. We provide the one-loop partially quenched chiral perturbation theory expressions both with and without including the effects of staggered quarks for all form factors at finite volume and with partially twisted boundary conditions for both the