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Protein design can be used to make better variants of a protein by changing the primary structure of proteins. An assay is needed to select for a better protein variant, generally these assays work on proteins with an activity. But sometimes proteins are designed to obtain a specific structure instead of an activity or function. These proteins often have no activity and there is no easy way to sel
Cardiovascular (CVD) is one of the most common causes of mortality. Apart from known causal risk factors such as smoking, obesity, dyslipidaemia and hypertension, chronic psychological stress has been suggested as a possible independent risk marker, also because the CVD burden follows a social gradient. Another self-reported variable is self-rated health (SRH) which in many studies has ben shown t
Bus rapid transit (BRT) systems have been recognized around the world by combining the advantages of urban rail transit systems with the flexibility and low cost of conventional bus systems. Although its introduction in different cities has helped to reduce greenhouse gas emissions and improve air quality, one of the major criticisms for these systems is that buses are usually powered by diesel, w
This Master Thesis was carried out at EuroMaint Rail AB in Malmoe. The assignment, which was provided by EuroMaint Rail AB, was to develop a device that makes the workload easier and enhances the safety in the engine replacement process for the locomotives RC1-4. Since the company at a national level started to introduce LEAN-production, management at the repair shop in Malmoe, Sweden, searched fo
Our paper tries to verify the relation between international banks’ expansion and international automotive corporations’ overseas business in China. Pervasive phenomena indicate that foreign banks take following their clients as the initial strategy when they start overseas business in China’s market. As many previous literatures analyzed, in the beginning stage in a new foreign market, multinatio
The purpose of this thesis was to develop and design a new machine for fatigue testing of bicycles. It was carried out for and in close cooperation with Svensk Maskinprovning AB, The Swedish Machinery Testing Institute. The machine was to test certain bicycle components according to a new standard of certification, valid in the entire EU. The goal was to attack the problem as openmindedly as possi
Background: Erysipelas is a common infection that often reoccurs, but only a few studies have investigated risk factors for recurrent episodes. How the natural course of events in the infection corresponds to the inflammatory signs is not well described. Objective: The aim of this study was to indentify risk factors for recurrent erysipelas and the possibility to study the course of events
Innovation in retailing is under-investigated in academia and yet a highly relevant concern given the current changes in the retail landscape. Although retailing is often characterized by a dynamic and highly competitive environment, retail organi- zations are not often considered as ‘innovative,’ at least when compared with manufacturing industries, or when using exist- ing innovation frameworks
Searches for scalar leptoquarks pair-produced in proton–proton collisions at s=13 TeV at the Large Hadron Collider are performed by the ATLAS experiment. A data set corresponding to an integrated luminosity of 36.1 fb- 1 is used. Final states containing two electrons or two muons and two or more jets are studied, as are states with one electron or muon, missing transverse momentum and two or more
A series of novel isochromanone based urotensin II receptor agonists have been synthesized and evaluated for their activity using a functional cell based assay (R-SAT). Several potent and efficacious derivatives were identified with 3-(3,4-dichlorophenyl)-6,7-dimethyl-3-(2-dimethylaminoethyl)isochroman-1-one (28) being the most potent compound showing an EC50-value of 51 nM, thereby being the most
Natural wetlands constitute the largest and most uncertain source of methane (CH4) to the atmosphere and a large fraction of them are found in the northern latitudes. These emissions are typically estimated using process ("bottom-up") or inversion ("top-down") models. However, estimates from these two types of models are not independent of each other since the top-down estimates usually rely on th
Photoreceptor potentials were recorded intracellularly from the isolated pineal organ of the teleost, Salmo gairdneri, maintained in tissue culture medium for 2-20 h. After electrophysiological characterization the photoreceptor cells were iontophoretically injected with Lucifer Yellow or with horseradish peroxidase for subsequent morphological identification. A brief flash of light elicited a hyp
Many items of culture which are conveyed from one culture to another may take verbal form, and then constitute what Jakobson called "translation proper." If such diffusions involve a co-occurrent change of semiotic systems, they are of such a different nature, that we better reserve another term for it: transposition. Whether or not accompanied by transpositions, such as pictures, translational ev
The result of a search for the pair production of the lightest supersymmetric partner of the bottom quark (b˜ 1) using 139 fb−1 of proton-proton data collected at s = 13 TeV by the ATLAS detector is reported. In the supersymmetric scenarios considered both of the bottom-squarks decay into a b-quark and the second-lightest neutralino, b˜1→b+χ˜20. Each χ˜20 is assumed to subsequently decay with 100%
Myocarditis most often affects otherwise healthy athletes and is one of the leading causes of sudden death in children and young adults. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically determined heart muscle disorder with increased risk for paroxysmal ventricular arrhythmias and sudden cardiac death. The clinical picture of myocarditis and ARVC may overlap during the early
The current paper addresses one of the core yet complex issues in the study of technology in organizations: the relationship between the social and the material. Many scholars in the field of Information Systems have used the notion of affordance as a lens to investigate and theorize this relationship. However, knowledge contributions in this area are often abstract and impractical, or at least co
Optically stimulated luminescence (OSL) signal properties of pellets from three types of NaCl (two household salts and one analytical grade salt) were investigated for their use in prospective dosimetry. Special attention was given to the OSL signal behaviour with time. The readout protocol was optimised in terms of preheat temperature, and the OSL signal yield of the NaCl pellet with time as well
Pilot injections are normally used for the reduction of diesel engine emissions and combustion noise. Nonetheless, with a penalty on the indicated thermal efficiency. The cost is reduced by the minimization of the pilot mass, which on its counterpart increases the risk of pilot misfire. Pilot misfire can have a higher penalty on the indicated efficiency if it is not compensated adequately. This pa
