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The aim of this work was to study the diffusion-related signal attenuation curves (signal-vs.-b curves) measured perpendicular and parallel to the neuronal fibers of the corticospinal tract in vivo and to determine whether effects of restricted diffusion could be observed when varying the diffusion time (T(D)). A biexponential model and a two-compartment model including exchange according to the K
Abstract Purpose: To assess the use of periscope grafts to the superior mesenteric artery (SMA) in extending the distal sealing zone of thoracic stent-grafts. Case Reports: Three patients with ruptured Crawford type I thoracoabdominal aortic aneurysms (TAAA) and 1 patient with a symptomatic type B dissection underwent endovascular repair; the celiac trunk was intraoperatively occluded in all patie
A large number of medical examinations involve images in some way. Images can be used for diagnostics, follow-up studies and treatment planning. In this thesis mathematical methods have been developed and adapted in order to analyze medical images. Several applications for different imaging modalities have been studied and the usefulness of such methods is demonstrated.A complete system for detect
Lime-hemp concrete (LHC) is a building material consisting of a lime-based binder combined with hemp shiv that is suitable for various building applications. This thesis aimed to elucidate the possibilities for using LHC for exterior walls in a cold, wet climate through investigating mechanical, thermal and moisture-related properties of the material. The mechan
För att skapa matematiska beskrivningar av fysiska fenomen inom bland annat naturvetenskap, teknik och medicin används ofta partiella differentialekvationer. Listan med tillämpningar kan göras hur lång som helst: sådana ekvationer kan beskriva hur en snöflinga bildas, hur strukturer deformeras när de utsätts för mekaniska krafter, hur partiklar interagerar på kvantnivå, hur blodet flödar i hjärnanSplitting methods are widely used temporal approximation schemes for parabolic partial differential equations (PDEs). These schemes may be very efficient when a problem can be naturally decomposed into multiple parts. In this thesis, splitting methods are analysed when applied to spatial splittings (partitions of the computational domain) and physical splittings (separations of physical processes)
Objective: To identify genetic variants that play a role in the pathogenesis of multiple system atrophy (MSA), we undertook a genome-wide association study (GWAS). Methods: We performed a GWAS with >5 million genotyped and imputed single nucleotide polymorphisms (SNPs) in 918 patients with MSA of European ancestry and 3,864 controls. MSA cases were collected from North American and European center
A heel ulcer is considered to be a serious complication in patients with diabetes, and there is limited information regarding outcome. In most of the literature, a poor prognosis is described. The aim of this study was to investigate a large cohort of ulcers located in the heel in patients with diabetes. Seven hundred and sixty-eight patients [median age 73 (17-98)], presenting with a heel ulcer a
This paper offers a probabilistic treatment of the conditions for argument cogency as endorsed in informal logic: acceptability, relevance, and sufficiency (RSA). Treating a natural language argument as a reason-claim-complex, our analysis identifies content features of defeasible argument on which the RSA conditions depend, namely: (1) change in the commitment to the reason, (2) the reason’s sens
Many countries have established disaster risk management (DRM) systems to reduce disaster risks and improve societal safety. Risk assessment in the DRM system is not only an important tool to identify potential risks, but also promotes DRM through conversations among stakeholders from different functional sectors and administrative levels. The municipal risk assessment, produced at the lowest admi
Background Immunotherapy targeting the amyloid beta (A beta) peptide is a potential strategy to slow the progression of Alzheimer's disease. We aimed to assess the safety and tolerability of CAD106, a novel active A beta immunotherapy for patients with Alzheimer's disease, designed to induce N-terminal A beta-specific antibodies without an A beta-specific T-cell response. Methods We did a phase 1,
L-DOPA, the most effective drug to treat motor symptoms of Parkinson's disease, causes abnormal involuntary movements, limiting its use in advanced stages of the disease. An increasing body of evidence points to the serotonin system as a key player in the appearance of L-DOPA-induced dyskinesia (LID). In fact, exogenously administered L-DOPA can be taken up by serotonin neurons, converted to dopam
The following article reports result from an extensive study with 25 blind users from Italy and Sweden performed during the summer 2001. The tasks reported here test recognition of geometrical objects, recognition of VRML objects, mathematical surfaces and navigation in a traffic environment. The outcome of these tests show that blind users are able to handle also quite complex objects and environ
In this work new methods based Nuclear Magnetic Resonance (NMR) have been developed to measure different kinds of structural properties in soft materials. The advantage of using NMR as a technique to measure material properties is that it is non-destructive, which makes it possible to measure on the actual piece of material that will be used for the application. One does not have to be concerned
Arm lymphoedema and impaired shoulder mobility and muscle strength are well known side-effects to breast cancer treatment. The aim of this prospective study was to follow closely and describe the arm volume, range of motion of the shoulder and muscle strength of the shoulder and hand after breast cancer treatment in order to form a basis for further studies in the area including physiotherapy inte
National differences in subjective well-being (SWB) and relationships between SWB and socio-demographic factors were investigated in samples of middle-aged employed Swedish (N = 316) and Lithuanian (N = 308) women. The results showed that the Swedish women scored significantly higher on each SWB component than their counterparts in Lithuania, except in extrinsic job satisfaction. For the Swedish s
Packaging serves a lot of purposes, and would be hard to do without. Packaging protects the goods during transport, saves costs, informs about the product, and extends its durability. A transport package is required to be strong and lightweight in order to be cost effective. Furthermore, it should be recycled because of environmental and economical concerns. Corrugated board has all of these featu
The effect of airborne particulate matter on human health is today of considerable research interest. Essential parameters include elemental composition sampling with low pressure cascade impactors and analysis by particle induced x-ray emission spectroscopy (PIXE). It is shown that the aerosol generated by arc welding operations is several orders of magnitude denser than aerosols in ambient air.
The standard way of representing an epistemic state in formal philosophy is in terms of a set of sentences, corresponding to the agent's beliefs, and an ordering of those sentences, reflecting how well entrenched they are in the agent's epistemic state. We argue that this wide-spread representational view-a view that we identify as a "Quinean dogma" - is incapable of making certain crucial distinc
We describe the clinical course of a female adolescent who was followed because of isolated microhematuria and hypocomplementemia before admission to hospital with a sudden onset of acute renal failure. At presentation, she exhibited complement consumption through the complement alternative pathway (AP) while other serologic tests were negative. Renal biopsy revealed dense deposit disease (DDD) wi
Abstract in UndeterminedContrary to the notion that altering our ordinary state of consciousness necessarily produces delusional beliefs and is generally deleterious, various findings in psychology and other disciplines suggest that 1) the ordinary state of consciousness does not provide an accurate mapping of reality and 2) alterations of consciousness can have various positive functions. Among t
