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The aim of this thesis was to investigate how the dimensions, placement and orientation of a combustible material can affect both fire characteristics such as flame height and heat release rate, and material characteristics such as surface lining classification. The extent of the effects was examined using a simplified version of a Single Burning Item (SBI) test. Several experiments were conducted
Current structural fire engineering practice generally assumes that the pre-flashover fire (growth) stage has a negligible influence on structural response and therefore considers only post-flashover conditions. The Eurocode parametric fire, widely used for structural fire design, follows this approach. This thesis investigates the influence of incorporating pre-flashover temperature on the therma
GROWTH. reconsiders the notion of growth in architecture, not as a process of continuous expansion, but as a cyclical condition of emergence, stabilization, decay, and regeneration observed in natural ecosystems. Positioned between regenerative agriculture, computational design, and material-driven architectural practice, the thesis investigates how the growth cycles of biotic materials can become
What does the EU’s emerging outbound review architecture reveal about the future limits of Article 63 TFEU in third-country capital relations? This thesis argues that the outbound investment screening agenda of EU is best understood as a constitutional stress test for external dimension of the Article 63 TFEU. While the potential outbound screening framework still relies on a soft-law review and r
Gas flaring is, apart from wasted energy, a source of greenhouse gases and air pollution associated with oil extraction activities. Despite this, small flares are often not included in existing global flaring inventories due to limitations in current detection methods. This study investigated whether satellite derived remote sensing data can be used to detect small gas flares in the Ecuadorian Ama
Objective: To study the association between self-reported physical activity level and overall attitudes and barriers to and facilitators of physical activity in people with axial spondyloarthritis (axSpA), and to compare health status and quality of life (QoL) in people with different levels of physical activity. Methods: Four hundred forty-five members of the Danish Patient Association for Axial
Background: Reducing the need for hospitalisation in patients with chronic obstructive pulmonary disease (COPD) is an important goal in COPD management. The aim of this study was to evaluate re-hospitalisation, treatment, comorbidities and mortality in patients with COPD who were hospitalised for the first time due to a COPD exacerbation. Methods: This was a retrospective, population-based observa
PURPOSE: We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and BRCA2 pathogenic variant carriers. METHODS: Retrospective cohort data on 18,935 BRCA1 and 12,339 BRCA2 female pathogenic variant carriers of European ancestry were available. Three versions of a 313 single-nucleotide polymorph
BACKGROUND: Gastrectomy including D2 lymphadenectomy is regarded as the standard curative treatment for advanced gastric cancer in Asia. This procedure has also been adopted gradually in the West, despite lack of support from RCTs. This study sought to investigate any advantage for long-term survival following D2 lymphadenectomy in routine gastric cancer surgery in a Western nationwide population-
Iron is an essential micronutrient for oxygen transport and mitochondrial metabolism and is critical for physical performance. Compromised iron stores are more commonly found among athletes, and females are especially at risk. Iron deficiency is generally treated using oral iron supplements. However, only a small proportion of ingested iron is absorbed, necessitating higher intakes, which may resu
Background: Age, sex, and body constitution may affect the shedding of membrane bound angiotensin-converting enzyme 2 (mACE2) and lead to a relative mACE2 deficiency. However, it is unclear if differences, reflected by serum renin levels, exist in the basal renin-angiotensin-system (RAS) between children and adults, boys, and girls as well as young women and young men. Furthermore, it remains to b
Background: We have previously shown an association with substantially improved survival in breast cancer and melanoma for desloratadine and loratadine users, and set out to find whether an improved survival can be seen in tumors with and without a known response to immune checkpoint therapy, such as anti-CTLA-4 or anti-PD-1. Methods: We investigated survival and use of six common H1-antihistamine
The current study examines whether there is a connection between Swedish L2 students' L1 and their spelling in Swedish.The data were collected through a spelling test conducted at SFI course levels C and D. The experiment was conducted in an urban area in Småland in three groups consisting of 37 course participants with 12 different L1s. People with Arabic as their L1 are the focus of the study du
Background: Mortality among critically ill COVID-19 patients has varied globally. In Sweden, geographic differences in mortality have also been observed. The current study aimed to determine whether mortality differences persist after adjusting for differences in case-mix, and to identify potential independent factors contributing to regional variations in mortality. Methods: We conducted a multic
Objective(s): Nitrite, a nitric oxide (NO) donor, increases insulin secretion from pancreatic islets and has positive metabolic effects in type 2 diabetes (T2D). Here, we test the hypothesis of whether nitrite-induced insulin secretion is due to blunting of diabetes-induced oxidative stress in the islets. Materials and Methods: T2D was created in male rats using a combination of streptozotocin at
BackgroundDiabetes and prediabetes are well-recognized risk factors for cardiovascular disease (CVD) and are marked by vascular endothelial dysfunction (ED). However, there is a scarcity of thorough population-based studies examining ED in individuals with diabetes/prediabetes free from manifest CVD. Here, we examined the association between ED assessed by reactive hyperaemia index (RHI) in the fi
OBJECTIVE: To compare neurofilament light (NfL) and tau as blood-based biomarkers for acute sports-related concussion (SRC) and determine whether their concentrations at different time points after the injury are associated with prolonged time to return to play (RTP).METHODS: A total of 288 professional hockey players were followed longitudinally from September 1, 2012, to April 30, 2015. Data col
Recent advances in tracking technology are based on the use of miniature sensors for recording new aspects of individual migratory behaviour. In this study, we have used activity data loggers with barometric and temperature sensors to record the flight altitudes as well as ground elevations during stationary periods of migratory songbirds. We tracked one individual of red-backed shrike and one gre
Aims: We tested whether parental alcohol use disorder (AUD) predicted adult offspring's likelihood of marriage and marriage to an AUD-affected spouse; whether effects differed as a function of the sex or number of affected parents; and whether they were robust to confounders. Design: Sex-stratified Cox and logistic regression models. Setting: Sweden. Participants: A total of 1 171 070 individuals
