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Object. Arterial vasospasm is the most common cause of delayed ischemic neurological deficits (DINDs) and one of the major causes of disability following subarachnoid hemorrhage (SAH). Current management of vasospasm involves intravascular volume expansion and hemodynamic augmentation with the goal of increasing cerebral blood flow (CBF). The purpose of this study was to examine the effects of vol
Birdsong is one of the main models in sexual selection studies. Most investigations focused on oscines in which male song and female preference learning occur. Yet, some non-oscines are well suited for such studies as well. In Columbidae song learning does not occur. However, like in oscines, song is involved in inter- and intra-sexual interactions. Surprisingly, experimental evidence of female so
Background: Hyper- as well as hypoglycemia may be detrimental for brain energy metabolism and even a moderate increase in blood glucose concentration can affect outcome adversely. During physiological conditions, glucose concentration obtained from microdialysis of subcutaneous adipose tissue adequately reflects plasma glucose concentration. This study examines whether this correlation is also obt
Background: An alternative to standard approaches to uncover biologically meaningful structures in micro array data is to treat the data as a blind source separation ( BSS) problem. BSS attempts to separate a mixture of signals into their different sources and refers to the problem of recovering signals from several observed linear mixtures. In the context of micro array data, "sources" may corres
The shear strength of the interface between bone and an injectable calcium phosphate bone substitute that cures to form a carbonated apatite (Norian SRS) was measured and related to the time that elapsed between injury and surgery. Eleven rabbits had a 3 mm drill hole made in the retropatellar aspect of the distal femur. After one week, the rabbits were reoperated on and the hole filled with Noria
Popular Abstract in Swedish Hemofili (blödarsjuka) A och B, är X-kromosomalt, recessivt, nedärvda sjukdomar som orsakas av brist på eller avsaknad av koagulationsfaktor VIII respektive IX i blodet (FVIII och FIX). Sjukdomen drabbar män och överförs till nästa generation av kvinnliga bärare, som vanligtvis inte själva har några blödnings-symtom. Blödarsjuka ger redan tidigt i livet upphov till blödThe general aim of this study has been to study the psychological, social and ethical aspects for carriers of haemophilia and their spouses, related to the development of techniques for carrier testing and for prenatal diagnosis (PD) of haemophilia. This was investigated by a semi-structured follow-up interview with 29 carriers of haemophilia with experience of PD by fetal blood sampling (FBS), an
Popular Abstract in Swedish Denna avhandling studerar kronisk venös sjukdom i nedre extremiteten, något som drabbar mellan 30 – 50% av den vuxna populationen i västvärlden. En viktig faktor i utredningen av kronisk venös sjukdom är s.k. reflux, vilket innebär att venklaffar inte förmår hindra blodet att rinna i ”fel” riktning. Därmed minskar möjligheten till ventryckssänkning i samband med arbete,Controversies exist regarding both what is required for a proper diagnosis of chronic venous disease (CVD), and what treatment to offer patients. An objective evaluation is mandatory to individualize treatment. This thesis deals with the evaluation of patients with CVD with specific emphasis on CEAP classification (C; clinical, E; etiological, A; anatomical, P; pathophysiological), symptoms and si
This thesis is based upon four original papers describing the characterisation of mantle cell lymphoma (MCL) tumours and cell lines in comparison with different populations of normal B cells. Gene expression profiling, which were used in the studies, has during recent years developed as an important tool in characterisation of different types of malignancies. In this thesis, the technique is used
In this paper the historically persistent mismatch between the information systems development and security paradigms is revisited. By considering the human activity systems as a point of reference rather than a variable in information systems security, we investigate the necessity for a change in the information systems security agenda, accepting that a viable system would be more user-centric by
In this chapter we analyze the pathways through which school choice leads to segregation in the multicultural setting of Malmö (Sweden), and in relation to an elite-oriented program: the natural science program. As a result of school choice reforms this program has grown rapidly in recent years, as has the number of students with an immigrant background attending it. In this chapter we examine whe
Abstract Inducible plant responses to damage, i.e. inducible defence responses and compensatory growth responses, are theoretically examined in an evolutionary and ecological context. Inducible defences are generally considered to be beneficial under conditions of low risk of herbivory and when initial damage is moderate. This study indicate that under these circumstances, localized defence respon
We have published previously a prototype of a decision model for anaemic patients with myelodysplastic syndromes (MDS), in which transfusion need and serum erythropoietin (S-Epo) were used to define three groups with different probabilities of erythroid response to treatment with granulocyte colony-stimulating factor (G-CSF) + Epo. S-Epo less than or equal to 500 U/l and a transfusion need of < 2
Background and Purpose: Leptin, an important hormone for body weight regulation, may be involved in the pathogenesis of cardiovascular manifestations of obesity. We tested whether leptin may be an independent risk marker for stroke in a case-referent study. Methods: Definitive acute stroke events, defined by MONICA criteria, were identified from October 1, 1995 to April 30, 1999. Referents without
Objective: To compare the efficacy of adalimumab, etanercept, and infliximab in patients with established rheumatoid arthritis (RA) taking concomitant methotrexate (MTX) by calculating the number needed to treat (NNT) using three different methods. Methods: A systematic literature search of the Cochrane Library, MEDLINE, and EMBASE was conducted from inception to 30 June 2006. Two pairs of investi
Pulmonary embolism (PE) can only be diagnosed with imaging techniques, which in practice is performed using ventilation/perfusion scintigraphy (V/P(SCAN)) or multidetector computed tomography of the pulmonary arteries (MDCT). The epidemiology, natural history, pathophysiology and clinical presentation of PE are briefly reviewed. The primary objective of Part 1 of the Task Group's report was to dev
Urogenital problems in the elderly female population are experienced by one third of women from the age 50 years and onward. Symptoms from the lower urinary tract include incontinence, urethritis, and recurrent urinary tract infections. Atrophic changes within the bladder neck and urethra could be corrected by estrogen administration even at doses so low that endometrial proliferation is avoided.
PURPOSE: To determine the effect of radiotherapy in doses 14 to 20 Gy on eradication of carcinoma-in-situ (CIS) testis and on the Leydig cell function. PATIENTS AND METHODS: Forty-eight patients presented with unilateral testicular germ cell cancer and CIS of the contralateral testis. The CIS-bearing testis was treated with daily irradiation doses of 2 Gy, 5 days a week, to a cumulative dose of 20
BACKGROUND AND PURPOSE: The purpose of this study was to evaluate whether grafting of fetal neocortical tissue 1 week after focal brain ischemia improved behavioral outcome and reduced secondary thalamic atrophy. METHODS: One week after distal ligation of the right middle cerebral artery in spontaneously hypertensive male rats, blocks of fetal neocortex (embryonic day 17) were homografted to rats
