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BackgroundPolypharmacy is increasing. The longitudinal association of polypharmacy and social isolation has not been previously reported. The aim of this study was to explore longitudinal associations of polypharmacy with loneliness and social isolation among older adults.MethodsParticipants aged 60 years and above in southern Sweden were invited for participation. A total of 1526 and 2556 partici
BACKGROUND: Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers.AIM: To assessed the associations of CHEK2 c.1100delC, radiotherapy, and systemic treatment with CBC risk and BCSS.METHODS: Analyses were based on 82,701 women diagnosed with a first primary invasive BC incl
Popular Abstract in Swedish Arbetet visar att restprodukter från fraktionering av vete är rika på kostfiber med olika funktionella och nutritionella egenskaper. Biprodukterna används för närvarande inte för vidare exploatering utan har endast användning som djurfoder. Ett ökat intag av kostfiber är önskvärt ur folkhälsosynpunkt, och det kommersiella värdet av restprodukterna skulle öka betydligt oDietary fibre is fermented in the colon to short-chain fatty acids (SCFAs), of which especially butyric and propionic acid may have health-promoting effects. One source of dietary fibre may be by-products from wheat, which are currently used as animal feed. The aim of the work presented in this thesis was to perform physicochemical and nutritional characterisation of dietary fibre in waste fractio
OBJECTIVES: To evaluate the safety of intra-articular sprifermin (primary), and to evaluate systemic exposure, biomarkers, histology, and other cartilage parameters in patients with advanced osteoarthritis (OA).METHODS: This was a first-in-human, double-blind, randomised, placebo-controlled trial of single and multiple ascending doses of sprifermin from 3-300 μg in knee OA patients scheduled for t
Chondrocytes isolated from the Swarm rat chondrosarcoma were incubated in culture with [1-3H]glucose for 30 min to 8 h. Labeled proteoglycans were isolated, treated with borohydride under alkaline conditions, and the three complex sugar structures purified: N- and O-linked oligosaccharides and chondroitin sulfate chains. The amount of incorporated radioactivity into each component sugar was analyz
Hypercalcemia in monoclonal gammopathy of undetermined significance (MGUS) presents a clinical challenge since it may indicate progression to multiple myeloma (MM) but could also be due to a multitude of unrelated disorders. To inform the approach to this clinical challenge, we conducted a nested cohort study within the iStopMM screening study. Of the 75,422 Icelanders aged 40 years and above who
As the largest river, Yangtze River Basin drains 20% of China’s land surface. The Yangtze River region is so important that it accounts for 40 percent of the nation's industrial output and 35 percent of its agricultural output. The densely populated and highly developed river delta supports China's economic backbone. More than 160,000 enterprises are based along the middle and lower River reaches
Aim: There is a knowledge gap regarding which patients with anorectal malformations (ARMs) are at highest risk of anorectal prolapse (AP), and which risk factors predispose to AP in ARM. The aims of the study were to define the frequency of AP after ARM reconstruction, and explore risk factors. Method: Data from the ARM-Net registry inserted between 2007 and 2023 were used. Inclusion criteria were
Objectives: IgA vasculitis (IgAV) in adults has been relatively under-investigated. Since outcomes are worse in other forms of vasculitis with increasing age, we investigated the outcomes of IgAV comparing younger adults (18-34), middle-aged adults (35-64) and elderly patients (≥64 years) focusing on kidney outcomes. Methods: We identified patients with renal biopsy-confirmed IgAV nephritis and co
OBJECTIVE: Cone beam computed tomography (CBCT) can accurately assess erosive disease in the hands, wrists and feet in established rheumatoid arthritis (RA). The aim of this study was to compare CBCT with conventional radiography (CR) for the assessment of erosions in patients with early RA.METHODS: CBCT and CR of the hands, wrists and feet of 17 patients with treatment naive early RA were assesse
AIMS: Patients with heart failure (HF) and iron deficiency experience poor health-related quality of life (HRQoL). We evaluated the impact of intravenous (IV) ferric carboxymaltose (FCM) vs. placebo on HRQoL for the AFFIRM-AHF population.METHODS AND RESULTS: The baseline 12-item Kansas City Cardiomyopathy Questionnaire (KCCQ-12), which was completed for 1058 (535 and 523) patients in the FCM and p
Standard treatment for patient with peritoneal metastases from colorectal cancer is cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). In recent years, the efficacy of oxaliplatin-based HIPEC has been challenged. An intensified HIPEC (oxaliplatin+irinotecan) in combination with early postoperative intraperitoneal chemotherapy (EPIC) has shown increased recurrence-fr
Background. The concept of schizotypal personality disorder (SPD) emerged from observations of personality characteristics common in relatives of schizophrenic patients. While often studied in family designs, few studies and none with genetic measures, have examined SPD in epidemiological samples. Methods. We studied individuals born in Sweden 1940–2000 with an ICD-10 diagnosis of SPD with no prio
Fine particle emissions were measured at two commercial grate fired boilers operating on moist fuel residues. The aim of this study was to characterize fine particle emissions with a view to pinpoint parameters influencing the emissions. Additionally effectiveness of used flue gas cleaning techniques was assessed. The results show that large quantities of fine particles are emitted to the atmosphe
ABSTRACT The genetic characteristics of two soft tissue tumors were investigated in the present study: pleomorphic hyalinizing angiectatic tumor (PHAT) and solitary fibrous tumor (SFT). PHAT is a benign soft tissue tumor of uncertain cellular origin and lineage of differentiation. Although PHAT is still poorly characterized at the genetic level, one reported case has shown a potential genetic ove
Små regulatoriska molekyler i vårt blod Sedan det mänskliga genomet kartlades i början av 2000-talet har stora upptäckter gjorts och teknikutvecklingen har gått fort. Dagens sekvenseringsmaskiner är kraftfulla och kan sekvensera hela det mänskliga genomet på bara två dagar. I mitt masterarbete har jag undersökt små korta RNA-molekyler i mänskligt blod. Denna typ av molekyler är mycket lovande somAbstract In recent years focused research aimed at finding new specific and sensitive biomarkers for detection, classification and, monitoring of human cancers has been ongoing. MicroRNAs (miRNAs) are small, 19-24 nucleotides, noncoding RNAs that are stably expressed in body fluids such as blood. These circulating RNAs have shown great promise as biomarkers, because the unique expression patterns
Calibration is an important _eld and is used everywhere from education, research and industry. Every electrical equipment has to be calibrated during manufacturing and even over time as it is worn down. The purpose of calibration is to come as close as possible to the true value. The question is how close is close enough and how close is possible? Because even the equipment used for calibration ne
LIDAR-data från mätstationen Polly, som är en del av Arrhenius-laboratoriet och belägen på Stockholms universitets tak, används för att bestämning av planetära gränsskiktshöjden. För detta ändamål användes en stabil ”wavelet covariance transform” metod för analys av LIDAR-datasignalerna från åren 2011-2012. Endast molnfria dagar med högtrycks- förhållande är med i undersökningen för att minska mänLIDAR data from the Polly system on the roof of the Arrhenius laboratory at Stockholm University are used to determine the planetary boundary layers (PBL) height distribution. To this end, a wavelet covariance transform method is employed to analyze LIDAR measured data signals from the years 2011-2012. Only data with high pressure cloud free condition are used to reduce “bad” data. The main result
The purpose of this investigation was to evaluate the personality questionnaire 30 aspects, which is based on the five-factor model. Our aim was to investigate the properties of the questionnaire through explorative factor analysis and reliability ratings. We also set out to explore the factor structure of the test to decide whether the instrument agreed with the five-factor model or not. The ques
