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A tensile fracture model for joints with rods or dowels loaded perpendicular-to-grain
Cliticisation in the acquisition of French as L1 and L2
The intense debate on continuity in child grammars has largely focused on the existence of Functional Categories (FCs) in early grammars despite differences in language use with adults (e.g., omissions, word order errors, lack of case marking). Simplified, the major theoretical explanations for these properties range from Maturational accounts (Radford 1990 and later) claiming an initial absence o
Effect of High Temperatures on Tensile Strength of Concrete
Antibody response in immunized rabbits measured with bacterial immunoglobulin-binding proteins
Excluded GM-specific IgG Subclass Genes in Health and Disease - Inborn Errors of Immunity
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Practical Aspects of Reduced Complexity LDPC Decoding using Forced Convergence
This thesis is an extension to the previous work done at Department of EIT in investigating the complexity reduction of LDPC decoding using the stochastic approximation method to improve the energy efficiency of energy-limited applica- tions, such as in mobile phones. The research carried out in this thesis investigates the complexity and conver- gence results of adaptive performance control algorit
PROFILING EXTRACELLULAR MATRIX REMODELING IN AN IN VITRO FIBROBLAST AND EPITHELIAL CELL CO-CULTURE MODEL
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease driven by persistent fibroblast activation, abnormal epithelial to mesenchymal signaling and excessive extracellular matrix (ECM) remodeling. Better pre-clinical models are needed to reproduce these processes and to support antifibrotic drug development. This thesis tested whether an in vitro co-culture model
Group A streptococci induce stronger M protein-fibronectin interaction when specific human antibodies are bound
Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. GAS’ M protein constitutes a primary target of the immune system due to its spatial configuration and dominance on the bacterial surface. Antibody responses targeting the M protein have been shown to favor the conserved C region. Such antibodies (Abs) c
IgG Binds Escherichia coli Serine Protease EspP and Protects Mice From E. coli O157:H7 Infection
Shiga toxin-producing Escherichia coli O157:H7 is a virulent strain causing severe gastrointestinal infection, hemolytic uremic syndrome and death. To date there are no specific therapies to reduce progression of disease. Here we investigated the effect of pooled immunoglobulins (IgG) on the course of disease in a mouse model of intragastric E. coli O157:H7 inoculation. Intraperitoneal administrat
Development and validation of a machine learning-based model to predict isolated post-challenge hyperglycemia in middle-aged and elder adults : Analysis from a multicentric study
Introduction: Due to the high cost and complexity, the oral glucose tolerance test is not adopted as the screening method for identifying diabetes patients, which leads to the misdiagnosis of patients with isolated post-challenge hyperglycemia (IPH), that is., patients with normal fasting plasma glucose (<7.0 mmoL/L) and abnormal 2-h postprandial blood glucose (≥11.1 mmoL/L). We aimed to develop a
Towards alkali-stable polymers and hydroxide exchange membranes functionalized with alicyclic quaternary ammonium cations
In the current work, cationic polymers functionalized with N-alicyclic quaternary ammonium (QA) cations were synthesized and characterized as potential hydroxide exchange membranes (HEMs) for application in fuel cells. Three different polymers, namely poly(arylene ether sulfone), spiro-ionene and poly(arylene alkylene), were explored as polymer backbones for the HEMs. Various mono- and spirocyclic
The feasibility of using Pareto fronts for comparison of treatment planning systems and delivery techniques
Pareto optimality is a concept that formalises the trade-off between a given set of mutually contradicting objectives. A solution is said to be Pareto optimal when it is not possible to improve one objective without deteriorating at least one of the other. A set of Pareto optimal solutions constitute the Pareto front. The Pareto concept applies well to the inverse planning process, which involves
Protein Arp and protein H from group A streptococci. Ig binding and dimerization are regulated by temperature
Direct comparison of two extended-half-life recombinant FVIII products : a randomized, crossover pharmacokinetic study in patients with severe hemophilia A
A Simulation Study Quantifying the Effects of Drive Cycle Characteristics on the Performance of a Pneumatic Hybrid Bus
In the study presented in this paper, the effect of different vehicle driving cycles on the pneumatic hybrid has been investigated. The pneumatic hybrid powertrain has been modeled in UT-Power and validated against experimental data. The GT-Power engine model has been linked with a MATLAB/simulink vehicle model. The engine in question is a single-cylinder Scania D12 diesel engine, which has been c
Mode of Coreceptor Use by R5 HIV Type 1 Correlates with Disease Stage: A Study of Paired Plasma and Cerebrospinal Fluid Isolates.
Abstract Through the use of chimeric CXCR4/CCR5 receptors we have previously shown that CCR5-tropic (R5) HIV-1 isolates acquire a more flexible receptor use over time, and that this links to a reduced viral susceptibility to inhibition by the CCR5 ligand RANTES. These findings may have relevance with regards to the efficacy of antiretroviral compounds that target CCR5/virus interactions. Compartme
Successful treatment of experimental glomerulonephritis with IdeS and EndoS, IgG-degrading streptococcal enzymes
Background. Anti-glomerular basement membrane (anti-GBM) disease often results in end-stage renal failure despite therapy with plasma exchange and immunosuppressive drugs. The newly discovered streptococcal enzymes IgG-degrading enzyme of S.pyogenes (IdeS) and endoglycosidase S (EndoS) act with remarkable specificity on circulating IgG. In this study, we investigate their ability in vivo to preven
