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Biological and structural characterization of murine TRALI antibody reveals increased Fc-mediated complement activation

Transfusion-related acute lung injury (TRALI) remains a leading cause of transfusionrelated deaths. In most cases, anti-leukocyte antibodies in the transfusion product trigger TRALI, but not all anti-leukocyte antibodies cause TRALI. It has been shown that the anti-major histocompatibility complex (MHC) class I antibody 34-1-2S (anti-H-2Kd) causes TRALI in BALB/c mice (MHC class I haplotype H-2Kd)

SciLifeLab Lund Day 2025 - Accelerating strategic research through collaboration, infrastructure, and innovation

23 oktober 2025 09:00 till 17:00 | Konferens Welcome to SciLifeLab Lund Day 2025! Join us for a dynamic day that brings together researchers, technology platforms, and strategic research initiatives to spotlight the powerful synergies driving life science forward in southern Sweden. This year’s program will feature:A showcase of SciLifeLab’s cutting-edge technologies and national resources, includ

https://www.lu.se/evenemang/scilifelab-lund-day-2025-accelerating-strategic-research-through-collaboration-infrastructure-and - 2026-04-24

Intraventricular Infusion of TrkB-Fc Fusion Protein Promotes Ischemia-Induced Neurogenesis in Adult Rat Dentate Gyrus.

Background and Purpose-We have previously shown that delivery of brain-derived neurotrophic factor (BDNF) through direct intrahippocampal gene transduction with a viral vector suppresses the formation of new dentate granule cells triggered by global forebrain ischemia. Here, we investigated whether inhibition of endogenous BDNF alters ischemia-induced neurogenesis in the dentate gyrus. Methods-Rat