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Reply to Pandey: IgG3 allotypes, modulation of antigen binding by constant domain changes, and therapeutic applications of Fc engineering
Recombinant factor IX Fc for the treatment of hemophilia B
Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E
A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors.
Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly
Early TCR alpha beta expression promotes maturation of T cells expressing Fc epsilon RI gamma containing TCR/CD3 complexes
In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of
Real-world prophylactic usage of recombinant factor VIII Fc in Sweden : A report from the Swedish national registry for bleeding disorders
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The search for safe haven assets in the time of a global pandemic
The global pandemic has initially negatively influenced the financial markets all over the world. As a consequence, the volatility in the stock markets increased and investors have experienced great monetary losses. In addition, the volatility spillover has increased between different markets and assets, which additionally amplifies the negative influence by the pandemic. This motivates the search
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Användning av Geografiska informationssystem (GIS) för att hjälpa polisen med det brottsförebyggande arbetet
Samverkan och samhällsnytta Här kan vi som forskare bidra genom vetenskapliga arbetssätt och analyser av bakomliggande faktorer och livsvillkor. Genom att använda evidensbaserade metoder kan vi komplettera myndigheternas arbetssätt och därigenom tillhandahålla en förbättrad lägesbild inför beslut om vilka förebyggande insatser som behövs sättas in” Nicklas Guldåker Mellan 2017 – och mars 2023 sked
https://www.keg.lu.se/samverkan-strategiska-kartan - 2026-05-19