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A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism Marcus Davidssona,1, Gang Wanga,1,2, Patrick Aldrin-Kirka, Tiago Cardosob, Sara Nolbrantb, Morgan Hartnora, Janitha Mudannayakea, Malin Parmarb, and Tom

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_pnas_4.pdf - 2026-07-24

Transsynaptic tracing and its emerging use to assess graft-reconstructed neural circuits T R AN S L A T I ONA L AND C L I N I C A L R E S E A R CH Transsynaptic tracing and its emerging use to assess graft- reconstructed neural circuits Andrew F. Adler1,2 | Anders Björklund1 | Malin Parmar1,2 1Developmental and Regenerative Neurobiology, Department of Experimental Medical Science, Wallenberg Neuro

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_stem_cells.pdf - 2026-07-24

Copyright © Rättsstaten En handledning för politiker 2 Copyright © The Raoul Wallenberg Institute of Human Rights and Humanitarian Law och The Hague Institute for the Internationalisation of Law 2012 ISBN: 91-86910-96-5 Denna skrift sprids på villkor att den inte genom handel eller något annat sätt lånas ut, säljs, hyrs ut eller på annat sätt sprids utan utgivarnas tillstånd i någon form av inbind

https://rwi.lu.se/app/uploads/2013/01/Rattsstaten-En-handledning-for-politiker.pdf - 2026-07-24

Gourse analysis GEON09 Global Environmental Change from a Geological Perspective Spring term 2022 General: The course was taught for the first time during the spring term of 2022. Therefore, this course analysis is especially important for our further development of the course. Twelve students completed the course, of which eight responded to the course evaluation (appended below). The course, whi

https://www.geology.lu.se/sites/geology.lu.se/files/2022-10/Coure%20analysis%20GEON09%202022.pdf - 2026-07-24

Master thesis Excited States in 103Sn by Lars-Erik Berglund Supervisor: Prof. Claes Fahlander Department of Physics Division of Cosmic and Subatomic Physics Lund University Sölvegatan 14, 223 62 Lund February 2000 2 ABSTRACT The 103Sn nucleus has been studied using data from a EUROBALL experiment. The ex- perimental technique used was based on the detection of γ-rays in coincidence with light evap

https://www.particle-nuclear.lu.se/sites/particle-nuclear.lu.se/files/2023-12/MSc-LBe.pdf - 2026-07-24

Excited Statesin the 39K and 39CaMirror Pairby Thomas Andersson February 1999Supervisors:Prof. Claes FahlanderDr. Dirk RudolphDepartment of PhysicsDivision of Cosmic and Subatomic PhysicsLund UniversitySölvegatan 14223 62 Lund AbstractThe mirror nuclei 39K and 39Ca were studied using data from a Gammasphere experiment. The4 charged-particle detector Microball and several neutron detectors were inc

https://www.particle-nuclear.lu.se/sites/particle-nuclear.lu.se/files/2023-12/MSc-TAn.pdf - 2026-07-24

An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood An Age-Related Exponential Decline in theRiskofMultiple Islet Autoantibody Seroconversion During Childhood https://doi.org/10.2337/dc20-2122 OBJECTIVE Islet autoimmunity develops before clinical type 1 diabetes and includes multiple and single autoantibody phenotypes. The objective was to

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/127_MP237_Bonifacio_Diab%20Care_2021.pdf - 2026-07-24

Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study ARTICLE Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study Thomas A. Auchtung 1,2✉, Christopher J. Stewart 1,3, Daniel P. Smith 1, Eric W. Triplett 4, Daniel Agardh5, William A. Hagopian 6, Anette G. Ziegler7,8,9, Marian J. Rew

https://www.teddy.lu.se/sites/teddy.lu.se/files/2023-02/142%20MP139_Auchtung_NatureComm_2022%20(1).pdf - 2026-07-24

A small percentage of women with cervical HPV infection progress to cervical neoplasia, and the risk factors determining progression are incompletely understood. We sought to define the genetic loci involved in cervical neoplasia and to assess its heritability using unbiased unrelated case/control statistical approaches. We demonstrated strong association of cervical neoplasia with risk and protec

Objectives. Systemic sclerosis (SSc) is heterogenous. The objectives of this study were to evaluate the purpose, strengths and limitations of existing SSc subset criteria, and identify ideas among experts about subsets. Methods. We conducted semi-structured interviews with randomly sampled international SSc experts. The interview transcripts underwent an iterative process with text deconstructed t

Popular Abstract in Swedish Kroniskt obstruktiv lungsjukdom (KOL) är en allvarlig folksjukdom vars huvudsakliga orsak är tobaksrökning. Det är den enda av de viktigaste dödsorsakerna som ökar och år 2020 beräknas KOL utgöra den 4:e vanligaste dödsorsaken i världen. Flera studier har försökt att bestämma förekomsten (prevalensen) av KOL i befolkningen men tyvärr har de oftast använt olika metoder oBackground – Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. However, there is little information on the prevalence and particularly on the incidence of COPD. Also, apart from the importance of tobacco smoking and a1-antitrypsin deficiency, information on contributing risk factors for the development of COPD is limited. Hypotheses – 1. Spi

The ATLAS Transition Radiation Tracker (TRT) performance depends critically on the choice of the active gas and on its properties. The most important operational aspects, which have led to the final choice of the active gas for the operation of the TRT at the LHC design luminosity, are presented. The TRT performance expected at these conditions is reviewed, including pile-up effects at high lumino

Traumatic brain injury causes long-term neurological motor and cognitive deficits, often with limited recovery. The inability of CNS axons to regenerate following traumatic brain injury may be due, in part, to inhibitory molecules associated with myelin. One of these myelin-associated proteins, Nogo-A, inhibits neurite outgrowth in vitro, and inhibition of Nogo-A in vivo enhances axonal outgrowth

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson disease (PD) known to date. The clinical features of manifesting LRRK2 mutation carriers are generally indistinguishable from those of patients with sporadic PD. However, some PD cases associated with LRRK2 mutations lack Lewy bodies (LBs), a neuropathological hallmark of PD. We investigated whether th

Therapeutic antibodies have transformed cancer therapy, unlocking mechanisms of action by engaging the immune system. Unfortunately, cures rarely occur and patients display intrinsic or acquired resistance. Here, we demonstrate the therapeutic potential of targeting human (h) FcγRIIB (CD32B), a receptor implicated in immune cell desensitization and tumor cell resistance. FcγRIIB-blocking antibodie

Popular Abstract in Swedish Varje år insjuknar mer än 8000 kvinnor i Sverige i bröstcancer, och 5 år efter diagnos är nära 90% fortfarande i livet. Trots att prognosen för majoriteten av patienterna är god, dör 1400 kvinnor årligen av bröstcancer. Till följd av detta pågår mycket forskningsarbete för att finna faktorer som bättre kan förutsäga prognos, prognostiska studier, men även för att finna Breast cancer is the most common tumour form and the second leading cause of death in solid tumours in women in the Western world. Despite improvements in the treatment, a considerable number of patients will relapse and die from their breast cancer. At the same time, a substantial number of patients will be over-treated, as they would have been cured by surgery and radiotherapy alone. In the meta

Haemophilia A (HA) is caused by defective synthesis of coagulation factor VIII(FVIII), which has serious effects on haemostasis; joints being the most common site of bleeding. The development of FVIII replacements has improved the situation for patients with haemophilia such that chronic arthropathy can be prevented, and life expectancy and the quality of life have increased. However, approximatel

Seventy five percent of the world's food crops benefit from insect pollination. Hence, there has been increased interest in how global change drivers impact this critical ecosystem service. Because standardized data on crop pollination are rarely available, we are limited in our capacity to understand the variation in pollination benefits to crop yield, as well as to anticipate changes in this ser

Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature1. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium2 of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we characterized mutational signatures using 84,729,690 somatic mutations from 4,645 who

BACKGROUND: Circulating adiponectin and leptin have been associated with risk of pancreatic cancer. However, the relationship between long-term exposure to these adipokines in the prediagnostic period with patient survival has not been investigated.METHODS: Adipokine levels were measured in prospectively collected samples from 472 patients with pancreatic cancer. Because of sex-specific difference