Filtyp
Purpose: Hypoxia in breast cancer is associated with poor prognosis and down-regulation of the estrogen receptor. Carbonic anhydrase IX (CA IX) is a hypoxia-inducible gene that has been associated with poor outcome in many epithelial cancers. Previous studies of CA IX in breast cancer have been carried out on mixed cohorts of premenopausal and postmenopausal patients with locally advanced disease
Background New treatment strategies for early rheumatoid arthritis are evolving rapidly. We aimed to compare addition of conventional disease-modifying antirheumatic drugs (sulfasalazine and hydroxychloroquine) with addition of a tumour necrosis factor antagonist (infliximab) to methotrexate in patients with early rheumatoid arthritis. Methods We undertook a randomised trial in 15 rheumatology uni
This study was designed to test the hypothesis that administration of granulocyte colony-stimulating factor (G-CSF; filgrastim) during induction chemotherapy with CHOP (cyclophosphamide, vincristine, doxorubicin, prednisone) or CNOP (doxorubicin replaced with mitoxantrone) in elderly patients with aggressive non-Hodgkin lymphoma (NHL) improves time to treatment failure (TTF), complete remission (C
The Archean basement in the northeastern part of the Kaapvaal craton is intruded by a large number of mafic dykes, defining three major dyke swarms, which collectively appear to fan out from the Bushveld Complex. Herein we present U-Pb baddeleyite ages for two of these dyke swarms, the northwest trending Badplaas Dyke Swarm and the east-west trending Rykoppies Dyke Swarm, and infer their correlati
Alvars are globally rare habitats with rich and distinctive vegetation-communities. Alvars are found on limestone bedrock which is also subject to quarrying for cement production. The increasing global need for cement results in either expanding existing quarries or the opening of new ones. Current legislation requires the restoration of limestone quarries after they are closed for quarrying and t
The raw material tier in companies’ supply chains can be a hotspot for sustainability issues like deforestation and resulting legal, reputational, financial and operational risks – yet companies’ supply chain management efforts as well as research on sustainable supply chain management still focus on direct suppliers due to poor upstream transparency. With technical progress, remote sensing and sa
This study investigates whether event construal of placement events varies between Mandarin Chinese and German speakers by comparing how native speakers of the respective languages speak and gesture about placement events. It has been argued that there are universal constraints on how languages encode placement events. However, languages arguably differ in their semantic divisions of placement eve
Research question: How can the participation in the COII support companies to open up? Methodology: The thesis applies a single case study design to examine an opening up process in relation to open innovation. The thesis used a qualitative research strategy with inductive design with influences of deduction. The primary data emerged from semi-structured interviews to grasp an in-depth understand
OBJECTIVES: The aim of the present study was to examine the prevalence and associated factors of dietary supplement use, particularly supplements containing vitamin D and fatty acids, in pregnant women enrolled in a multi-national study. DESIGN: The Environmental Determinants of Diabetes in the Young (TEDDY) study is a prospective longitudinal cohort study. Maternal dietary supplement use was self
Aims/hypothesis There has been long-standing debate about whether diabetes is a causal risk factor for pancreatic cancer or a consequence of tumour development. Prospective epidemiological studies have shown variable relationships between pancreatic cancer risk and blood markers of glucose and insulin metabolism, overall and as a function of lag times between marker measurements (blood donation) a
To determine the relationship between long-term change in activities of daily living (ADL) and falls in the elderly and to identify characteristics of groups at risk for falls.
Patients with spinal stenosis with concomitant degenerative spondylolisthesis (DS) and predominance of back pain have been shown to have inferior outcome after surgery. Studies comparing outcome according to preoperative pain predominance and treatment received are lacking.
The main goal with this thesis was to investigate the possibility to reduce the number of blades in a high pressure gas turbine row. The reason for this study was the interest to reduce the amount of cooling air needed within the blade row by reducing the wetted area, hopefully without losing efficiency. Another reason for reducing the number of blades was to reduce the costs. A new design of an
The thesis explores the interaction between patent rights for Standard Essential Patents(SEP) and competition law, particularly Article 102 of the Treaty on the Functioning of the European Union(TFEU), within the context of the European Union(EU) , and compares this interaction with the relevant provisions in the proposed EU SEP regulation COM(2023)232. Three research questions will be discussed:
Globaliseringen och den teknologiska utvecklingen som nya möjligheter innebär en teknologi som producerar elektroniskt avfall. Industriländerna producerar, konsumerar och tar del av förtjänsterna för att sedan olagligt transportera avfallet till utvecklingsländer. I samband med dumpning av elektroniskt avfall uppkommer risker vilka vi ämnar att undersöka. För att förstå konsekvenserna av dumpninge
In recent years outsourcing of public health care activities has increased in Sweden. Outsourcing of public health care activities involves possibilities of innovation and improvement according to many, but there are difficulties with how to maintain and control quality in the outsourced activities. The focus of this thesis is on how quality is ensured when public activities are subject to contrac
In this thesis, I address the potential success factors of sonic branding. By extensively examining sound identities and sonic logos, across all the possible phases of its creation and implementation; I am conducting this study with the ambition of finding, mapping and analyzing its potential success factors. My main purpose in carrying out this study is hence to contribute to a clearer, more focu
