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Bacillus thuringiensis (Bt) strains naturally produce pesticidal proteins as nanocrystalline inclusions that are extraordinarily stable in aqueous environments, but which dissolve selectively at specific pH conditions. These proteins have been used in agriculture for >50 years and are critical to global food security. The majority of previously determined Bt Cry protein structures lack the extende
Carotid sinus massage (CSM) is essential in evaluating recurrent unexplained reflex syncope, as it uniquely identifies cardioinhibitory forms that other tests may miss. CSM is largely underused in clinical practice outside dedicated syncope facilities and, when performed, its execution varies, as does the interpretation of results. Underuse affects the diagnostic yield of CSM in the syncope evalua
Popular Abstract in Swedish Skador på skelettet kan uppstå efter bl.a. olyckor, tumörkirurgi eller strålning. Ofta är sådana skador mycket handikappande då de påverkar kroppens funktion, stabilitet och utseende. Om benvävnad saknas eller måste bytas ut använder man sig idag av mikrokirurgiska metoder, där man flyttar kroppseget ben från ett ställe till ett annat. Tyvärr innebär detta att man skapaBone deficiencies, caused by malformations, trauma or adverse effects from medical treatments, are a clinical challenge and often associated with reduced physical function and quality of life. Autologeous bone grafts can be used to reconstruct skeletal defects, but the right size and quality of bone might not always be available and even so, donor-site morbidity might follow. A pre-fabricated or t
Popular Abstract in Swedish Avhandlingen består av fyra delstudier och är tematiskt uppdelad i två delar. I den första delen undersöker jag vilken betydelse betyget i Gymnastik (nuvarande Idrott & Hälsa) har för framtida sjukdom med fokus på rörelseorganen. I den andra delen undersöker jag vilken betydelse isometrisk muskelstyrka (d.v.s. kraft alstrad utan nämnvärd förkortning av muskeln) har Although Physical Education (PE) is a part of the school curriculum in many countries, the association between the performance in PE and later morbidity is largely unknown. An important marker of health, cardiorespiratory fitness is inversely associated with future cardiovascular disease (CVD) and mortality. It has been suggested that muscle strength is associated in a similar way. However, whethe
Popular Abstract in Swedish Ett kombinerat syn- och hörselhandikapp påverkar vår möjlighet att kommunicera med omvärlden och det påverkar barnets möjlighet att utvecklas. De senaste decennierna har det skett stora framsteg för patienter med syn- och hörsel handikapp. Utvecklingen av cochlea-implantat under 80- och 90-talen har inneburit en revolutionerande förändring för barn födda med ett hörselhA variety of disorders can cause retinal degeneration and hearing impairment, and it is of great value to have an early diagnosis since there is a large variation in phenotype and prognosis both within and between the different disorders. The general aim of this thesis was to characterize the retinal function, to describe the phenotype, and – where appropriate – to relate the phenotype to genotype
The generation of thrombin by the prothrombinase complex constitutes an essential step in hemostasis, with thrombin being crucial for the amplification of blood coagulation, fibrin formation, and platelet activation. In the prothrombinase complex, the activated form of coagulation factor V (FVa) is an essential cofactor to the enzyme-activated factor X (FXa), FXa being virtually ineffective in the
Popular Abstract in Swedish Diabetes mellitus är en endokrin sjukdom. Hos friska individer producerar beta och alpha cellerna i bukspottkörteln insulin och glukagon, de viktigaste hormonerna för att reglera blodglukos¬koncentrationen. Insulin utsöndras som svar på förhöjda blodglukosnivåer. Hormonet minskar glukosproduktion från levern och ökar glukosupptaget samt dess användning och lagring i fetType 2 Diabetes (T2D) is a multifactorial disease, which has made it difficult to resolve its pathophysiology. We investigated processes that could contribute to the development of T2D. In addition to well-known hallmarks of the disease, such as defective insulin secretion, insulin resistance and perturbed glucagon secretion, we aimed to find a possible role for CLOCK genes in the pathogenesis of
Popular Abstract in Swedish Idag behöver människor som talar, tänker och lever på olika sätt mer än någonsin kunna kommunicera med varandra. Ett självklart språk för dessa kontakter är för en svensk ofta engelska. Det lär sig varje elev under minst tio år i vår skola. Men för att kunna förstå andra bättre, fordras också att vi blir medvetna om skilda sätt att uppfatta världen omkring oss. Vi behövThe aim of this study is to examine the prospects of developing intercultural understanding through English as a foreign language (EFL) education in the Swedish comprehensive school. This overall aim is split into two subordinate aims: (1) to analyse and problematize the intercultural dimension of EFL as three discourses, research discourse, authority discourse and teacher discourse; (2) to relate
Genome-wide association studies (GWAS) have begun to identify the common genetic component to ischaemic stroke (IS). However, IS has considerable phenotypic heterogeneity. Where clinical covariates explain a large fraction of disease risk, covariate informed designs can increase power to detect associations. As prevalence rates in IS are markedly affected by age, and younger onset cases may have h
Popular Abstract in Swedish Det samlade temat för de sju artiklarna i denna avhandling är att se på hur modern national-ekonomiska teori, som behandlar problem rela-terade till förekomsten av asymmetrisk infor-mation, kan användas för att studera insatser för åstadkomma bättre hälsa. Artiklarna rör dels vård på sjukhus,dels produktionen av läkemedel. För sjukhusen handlar det om hur man via olika The common theme of this thesis is the analysis of asymmetric information when applied to the market for health care production. The thesis consists of six more or less independent papers and an introduction to the thesis were purpose and methodology are stated (part one). Part two is an investigation into the pricing of pharmaceuticals in Sweden. This chapter deals with issues such as cost sharin
Popular Abstract in Swedish Evolutionsteorin säger att de anpassningar som leder till en ökad mängd ungar och ättlingar i senare led kommer att sorteras fram av det naturliga urvalet. Det är dock inte alltid så självklart vad som kommer att gynnas av selektionen. Ofta får hanar mer avkomma om de parar sig med många honor, i stort sett oavsett hur de uppnår detta. Hanliga anpassningar för detta ändIn sexual conflicts and conflicts between parents and offspring, natural selection acts in different directions on the two sides. For example, males may be selected to achieve many mates, but female fitness may be maximised by monogamy. In this thesis I study the evolutionary outcome of these situations mainly by theoretical modelling. I present an empirical investigation of mating interactions in
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Öroninflammtionen är en av våra vanligaste åkommor, och den drabbar framför allt små barn. Av alla bakteriella infektioner är det den som oftast för oss till läkare. Vanligen resulterar läkarbesöket i en kur med bakteriedödande läkemedel som penicillin. P.g.a den idag höga konsumtionen av penicillin och liknande medel, är risken påtagAcute otitis media (AOM) is the most common illness diagnosed during early childhood. One of the major etiologic agents is Haemophilus influenzae. Apart from AOM, this organism can cause a broad range of infectious diseases such as meningitis, epiglottitis, arthritis, and pneumonia. Despite the importance of H.influenzae, the mechanisms by which this heterogenous group of bacteria mediates the inf
Popular Abstract in Swedish Målsättningen i denna avhandling är att identifiera funktionen hos COMP (Cartilage Oligomeric Matrix Protein). Detta protein finns framförallt i brosk och sena. Dessa vävnader tillhör bindväven och har till funktion att ta upp och fördela belastning, utgöra ett skydd och förmedla transport av olika ämnen. De är uppbyggda av ett fåtal celler inbäddade i en dominerande exConnective tissues contain a prominent extracellular matrix that provides mechanical and physical properties. This extracellular matrix contains as a major constituent a network of collagen fibres. These are composed of collagen fibrils, which in turn are assembled from many collagen molecules aligned parallel to each other. Several proteins, e.g. collagens, leucine-rich repeat proteins and thromb
Popular Abstract in Swedish Avhandlingen presenterar ett närstudium av fjorton centrala pjäser skrivna av den svenske författaren Lars Norén (1944-) under perioden 1979-90. I centrum ställs frågan om den ouppklarade relationen till modern, i första hand hos de vuxna, vanligtvis redan in i medelåldern hunna barn som gestaltas i dessa pjäser. I den krisdrabbade intimsfär som Noréns huvudsakligen skiThis dissertation presents a close study of fourteen central dramas written by the Swedish author Lars Norén (1944-) between 1979 and 1990. The question at issue is the unfinished condition of the relation to the mother, mainly among the grown-up, in most cases middle-aged children portrayed in the plays. In the crisis of intimacy, Norén's major thematic motif in his dramatic works of the 1980s ("
This study was undertaken to investigate the prevalence of coeliac disease in children and adolescents with Turner syndrome. Eighty-seven children and adolescents with Turner syndrome were screened for IgA- antiendomysium antibodies (EMA) and IgA-antigliadin antibodies (AGA), 5% (4/87) being found to be EMA-positive, and 15% (13/87) to have AGA levels above normal. Of the 10 patients who were eith
The 7Be fragments produced in one-proton removal from relativistic 8B nuclei of 936 MeV/nucleon in a carbon target have been detected in coincidence with γ rays emitted by these fragments at the reaction target. It is found that 13 ± 3% of the 7Be fragments are released in the 429 keV excited state, 7Be*, which gives direct experimental information on the ground state configuration of 8B. The long
The dioxygen we breathe is formed by light-induced oxidation of water in photosystem II. O2 formation takes place at a catalytic manganese cluster within milliseconds after the photosystem II reaction centre is excited by three single-turnover flashes. Here we present combined X-ray emission spectra and diffraction data of 2-flash (2F) and 3-flash (3F) photosystem II samples, and of a transient 3F
Rapid climate warming in the tundra biome has been linked to increasing shrub dominance. Shrub expansion can modify climate by altering surface albedo, energy and water balance, and permafrost, yet the drivers of shrub growth remain poorly understood. Dendroecological data consisting of multi-decadal time series of annual shrub growth provide an underused resource to explore climate-growth relatio
RIKSAVTAL 1 RIKSAVTAL mellan Svensk Scenkonst och Teaterförbundet samt Akademikerförbunden avseende anställda vid offentligt finansierade teaterinstitutioner 2020.11.01 – 2023.03.31 2 Innehållsförteckning 1 Inledande bestämmelser…………………………………………………………………..5 1.1 Avtalets omfattning .................................................................................................... 5 1.2 Undantag ..
