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Despite the immense importance of enzyme-substrate reactions, there is a lack of general and unbiased tools for identifying and prioritizing substrate proteins that are modified by the enzyme on the structural level. Here we describe a high-throughput unbiased proteomics method called System-wide Identification and prioritization of Enzyme Substrates by Thermal Analysis (SIESTA). The approach assu
BACKGROUND AND AIMS: Atherosclerosis is a lipid-driven chronic inflammatory disorder of the arteries, and monocytes and macrophages play a central role in this process. Within the atherosclerotic lesion, macrophages can scavenge modified lipids and become the so-called foam cells. We previously reported that the epigenetic enzyme Kdm6b (also known as Jmjd3) controls the pro-fibrotic transcriptiona
PURPOSE: To characterize the ocular phenotype resulting from mutation of Rab38, a candidate gene for Hermansky-Pudlak syndrome.METHODS: Chocolate mice (cht, Rab38(cht/cht)) and control heterozygous (Rab38(cht/)(+)) and wild-type mice were examined clinically, histologically, ultrastructurally, and electrophysiologically. Mice homozygous for both the Rab38(cht) and the Tyrp1(b) alleles were similar
Here we describe the parametric response map (PRM), a voxel-wise approach for image analysis and quantification of hemodynamic alterations during treatment for 44 patients with high-grade glioma. Relative cerebral blood volume (rCBV) and flow (rCBF) maps were acquired before treatment and after 1 and 3 weeks of therapy. We compared the standard approach using region-of-interest analysis for change
Det var ett yrvaket och oförstående Europa som från och med 1991 såg konflikterna i Jugoslavien blossa upp i den egna europeiska ”bakgården”. Successivt under hela 1990-talet utvecklades upplösningskonflikten till en rad olika krig, och inte nog med att detta; stridigheterna uppfattades dessutom som ovanligt våldsamma, råa och obegripliga. Framför allt västerländska journalister, universitetsakade
A series of phosphorylated test peptides was studied by electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry (ECD FT-ICR MS). The extensive ECD-induced fragmentation made identification of phosphorylation sites for these peptides straightforward. The site(s) of initial phosphorylation of a synthetic peptide with a sequence identical to that of the phosphorylati
De flesta anser nog att kemi och speciellt teoretisk kemi är ett mycket komplext ämne, medan lera nog anses som ett begripligt koncept. Det man kanske inte tänker på är att många leror utgörs till stor del av elektrostatiskt laddade nanopartiklar där dess beteende kan förstås genom just ämnena kemi och teoretisk kemi. De laddade nanopartiklarna, även kallade lerplattor, är formade som tunna pannkaMany clay minerals consist of charged nanoplatelets that swell in an aqueous solution. The swelling and the microstructure depend on the type of clay mineral but are also dependent on, for example, the ionic composition and the temperature of the solution. The synthetic clay mineral Laponite and the natural clay mineral montmorillonite have been studied experimentally and theoretically. The swelli
Abstract in UndeterminedPlans for the European Proteomics Association (EuPA) were conceived and established during 2004 and 2005, and culminated in the formal inception of the Organisation during the 4th HUPO World Congress held in Munich in 2005. The mission from the outset has been three-tiered and is to: i) strengthen the national Proteomics organizations in their efforts; ii) to co-ordinate an
The ATLAS Transition Radiation Tracker (TRT) performance depends critically on the choice of the active gas and on its properties. The most important operational aspects, which have led to the final choice of the active gas for the operation of the TRT at the LHC design luminosity, are presented. The TRT performance expected at these conditions is reviewed, including pile-up effects at high lumino
Relativistic projectile fragmentation of Pb-208 has been used to produce isomers in neutron-rich, A approximate to 190 nuclides. A forward-focusing spectrometer provided ion-by-ion mass and charge identification. The detection of gamma-rays emitted by stopped ions has led to the assignment of isomers in Ta-188, W-190, Re-192, Re-193, Os-195, Ir-197, Ir-198, Pt-200, Pt-201, Pt-202 and Au-203, with
Popular Abstract in Swedish Artros (ledsvikt) är en vanligt förekommande ledsjukdom, som ofta leder till nedbrytning av ledbrosk och förändring i ledstrukturen i övrigt. Sjukdomen kan medföra symptom som smärta, svullnad och stelhet, vilket leder till nedsatt ledfunktion. I Sverige utförs det per år ca 15000 protesoperationer (utbyte till konstgjord led) p.g.a. artros. Tidigare studier har visat aMeniscectomy is recognized as an important risk factor for the development of knee osteoarthritis (OA), a disease that traditionally has been considered as a simple "wear and tear" phenomenon. However, despite numerous reports, little evidence has been presented that a limited meniscal resection, compared with a more extensive resection, reduces the risk of OA by preserving meniscal function. Why?
Context:There is little information on the potential impact of serum 1,25-dihydroxyvitamin D [1,25(OH)(2)D] on bone health including turnover.Objective:The objective of the study was to determine the influence of 1,25(OH)(2)D and 25-hydroxyvitamin D [25(OH)D] on bone health in middle-aged and older European men.Design, Setting, and Participants:Men aged 40-79 years were recruited from population r
Popular Abstract in Swedish Brist på fria radikaler kan ge artrit Fagocytiska celler i vårt immunförsvar producerar fria syre-radikaler för att eliminera fagocyterade (uppätna) mikroorganismer. Produktionen av dessa syre-radikaler sker med hjälp av ett enzymkomplex (NADPH oxidas) i cellmembranet samt i membranet på de fagosomer, innehållande mikroorganismer, som bildas i och med fagocytos. MännisThe aim of this thesis is to defend a novel mechanism that triggers arthritis susceptibility in both rats and mice through reduced production of reactive oxygen species (ROS), but also to introduce a novel model for chronic relapsing arthritis. Five papers are included, all of which employ animal models for rheumatoid arthritis and one that also uses animal models for multiple sclerosis. Paper I a
Popular Abstract in Swedish Övergödning av hav, sjöar och vattendrag beror på att näringsämnen som bl.a. kväve och fosfor tillförs i sådana mängder att ekosystemen kommer i obalans. Tillförseln gynnar en riklig tillväxt av cyanobakterier, tång och sjögräs som sedan vid sin död bryts ner av mikroorganismer som konsumerar syret som finns i vattnet. När syrefria förhållanden har uppstått gynnas andraSome of the main factors affecting the biological removal of nutrients in wastewater treatment plants have been investigated. The influence of low concentrations of dissolved oxygen and the redox potential on the denitrification, activity of activated sludge was studied in batchwise experiments. Oxygen was found to have a negative effect on denitrification even when present at concentrations lower
Popular Abstract in Swedish Intensifieringen av jordbruket under de senaste sextio åren har resulterat i en dramatisk produktionsökning av framförallt spannmål. Denna typ av produktion, speciellt det mest intensiva s.k. industrijordbruket, har samtidigt också resulterat i en ohållbar degradering av ekosystemen och miljön, till exempel förlust av biologisk mångfald, utsläpp av växthusgaser, förgiftSeveral studies have found that organic farms support higher biodiversity, but results vary between studies such that some also show no or even negative effects. There can be many reasons why studies comparing organic and conventional farming show conflicting results. The efficacy of organic farming can depend on focal taxa, landscape context, study scale and the proportion of organically managed
Popular Abstract in Swedish NY METOD ATT ANALYSERA EKG KAN FÖRBÄTTRA DIAGNOSTIK AV HJÄRTSJUKDOM Hjärtsjukdom står för en betydande del av sjukvårdskonsumtionen och är en av de vanligaste dödsorsakerna i västvärlden. Förträngningar i hjärtats kranskärl är den enskilt vanligaste orsaken till hjärtsjukdom. Tillståndet resulterar i nedsatt blodflöde och syretillförsel till den arbetande hjärtmuskulatAnalysis of high-frequency QRS components (HF-QRS) is one of the emerging methods for increasing the diagnostic performance of the electrocardiogram (ECG). The overall objective of the thesis is to investigate whether analysis of HF-QRS has the ability to provide information about ischemic heart disease and so serve as an adjunctive diagnostic tool in several clinical situations. Investigation of
let‐7 regulates radial migration of new‐born neurons through positive regulation of autophagy Article let-7 regulates radial migration of new-born neurons through positive regulation of autophagy Rebecca Petri, Karolina Pircs, Marie E Jönsson, Malin Åkerblom, Per Ludvik Brattås, Thies Klussendorf & Johan Jakobsson* Abstract During adult neurogenesis, newly formed olfactory bulb (OB)
https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/embj.201695235.full_.pdf - 2026-05-02
Anvisningar för sökande till Masterprogrammet i Fri Konst, 120 hp (Master of Fine Arts) Läsår 2018/2019 Sista ansökningsdag 3 april 2018 V 1.0 Hålltider och allmän information Ansökan till masterprogrammet i fri konst vid Konsthögskolan i Malmö sker i två steg, dels på Antagning.se, dels på Konsthögskolans ansökningsportal där arbetsprover laddas upp. Notera att din ansökan inte kan behandlas om i
https://www.khm.lu.se/en/sites/khm.lu.se.en/files/mastsve2018.pdf - 2026-05-02
