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Background: Despite considerable racial and geographical differences in human phenotypes and in the incidence of diseases that may be associated with sex steroid action, there are few data concerning variation in sex steroid levels among populations. We designed an international study to determine the degree to which geography and race influence sex steroid levels in older men. Methods: Using mass
An automated on-line sampling method was developed using microdialysis as the simultaneous sampling and sample pre-treatment technique. The extraction fraction values of microdialysis probes sampling different eicosanoids were investigated. The impact of cyclodextrins in the perfusion liquid used for sampling hydrophobic eicosanoids in biological systems was also studied. The total time for one an
OBJECTIVE: To compare the prevalence of synovitis, pain and radiographic progression in non-erosive and erosive hand osteoarthritis (HOA), and to explore whether the different rate of disease progression is explained by different levels of synovitis and structural damage.DESIGN: We included 31 and 34 participants with non-erosive and erosive HOA at baseline, respectively. Using Generalized Estimat
The occurrence of clonal chromosome aberrations in short-term cultures from synovia, osteophytes, and cartilage from patients with osteoarthritis (OA) was recently reported. Among these aberrations, a recurrent involvement of chromosome bands 12q13-15 in structural rearrangements was detected in both synovia and osteophytes. Chromosomal abnormalities of 12q13-15 are frequent among malignant and be
För under vilka förutsättningar stater kan reservera sig till vissa bestämmelser i traktat, som de ändock vill binda sig till, regleras framför allt i Wienkonventionens artikel 19. Stater får enligt denna artikel göra reservationer såvida inte: (a) en reservation är förbjuden enligt fördraget, (b) fördraget föreskriver att endast reservationer av visst slag får göras och reservationen inte är av dFor the conditions under which States may reserve themselves to certain provisions of a Convention, which they nevertheless wish to oblige themselves to, are regulated in Article 19 VCLT. States may make reservations under this Article unless: (a) a reservation is prohibited by the treaty, (b) the treaty provides that only reservations of a certain kind – and the reservation in question is not of
The labour law regulation is mainly found in Employment Protection Act (SFS 1982:80). It says that an employer needs to have just cause for a dismissal. Just causes for dismissal are divided into two categories: circumstances relating to the employee, also called personal reasons, and circumstances relating to the enterprise, so called redundancy. Reduced working capacity because of disability is
International human rights bodies that monitor and report human violations across the world like Human Rights Watch, Amnesty International, among others have found that forced labour is being exacted in the armed conflict that has been raging for many years now in the DRC. Armed groups have systematically abducted civilians in the DRC for purposes of forced labour and sexual slavery as part of the
The NA44 experiment has measured single-particle inclusive spectra for charged pions, kaons, and protons as a function of transverse mass near midrapidity in 158A GeV/c Pb+Pb collisions. From the particle mass dependence of the observed m(T) distributions, we are able to deduce a value of about 120 MeV for the temperature at thermal freeze-out. From the observed ratios of the rapidity densities, w
Background: Over the last 20 years stress at work has been found to be predictive of several conditions such as coronary heart disease, high blood pressure and non- specific sick leave. The Karasek demand/ control/ strain concept has been the most widely used in prospective epidemiological studies. Objectives: To describe distribution in Karasek's demand/ control ( DC) dimensions as well as preval
Begreppet barnets bästa är inte något nytt begrepp inom den svenska familjerätten. Det är ett begrepp som med tiden har mognat och blivit allt mer anpassat till barnets behov. I denna uppsats ges till en början en historisk återblick kring barnets bästa och en inblick i hur utvecklingen har sett ut i den svenska rätten. Den tar också fasta på den nuvarande lagstiftningen för barnets bästa och barnThe term the best interest of the child is not a new concept in the Swedish family law. It is a concept that has developed with time and become more and more adapted to the child's needs. In this paper is initially given a retrospective about the best interests of the child and an insight into how the development has been in the Swedish law. It also takes note of the current legislation for th
Introduction: Currently, patient specific dosimetric measurements on diode arrays such as Delta4® (ScandiDos AB) is a part of standard quality assurance (QA) for RapidArc® (RA) at Herlev University hospital. However, a standing issue is the interpretation of the results from dosimetric measurements into consequences in the delivered absorbed dose to the patient. Furthermore, measurements are time
Min forskningsfråga är i vilken utsträckning rätten till abort är skyddad i Europarådets system, med fokus på rättspraxis från den Europeiska domstolen för de mänskliga rättigheterna. Teorier och förklaringsmodeller som används för att analysera policybeslut, lagstiftning och rättsfall gällande abort i Europarådet presenteras först. I korthet menar dessa teorier att det finns en strukturell diskrMy research question is to what extent the right to abortion is protected in the Council of Europe system, with a focus on the case law of the European Court of Human Rights. First, theories and models of explanation are presented that are used to analyse the policies, legislation and cases on the issue abortion the Council of Europe. In short, these theories state that there is a structural disc
Människohandel för sexuella ändamål är ett komplext fenomen och ett globalt problem som både berör och upprör. Människohandel är gärningar som syftar till ett efterföljande utnyttjande av offret och ett brott där skyddssyftet är personlig frihet och frid. Det är också ett sammansatt problem, det vill säga att det innefattar bland annat brott mot mänskliga rättigheter, organiserad brottslighet, migHuman trafficking for sexual purposes is a complex phenomenon and a global problem that upsets. Human trafficking is an acts aimed to subsequent exploit the victim and a crime which aim the protection of personal liberty and peace. It is also a complex problem, that includes human rights violations, organized crime, migration, gender, poverty and social, economic and political differences between
The problem of windfall has recently become more and more frequent in marine insurance. The solution to the problem would affect both international business and the insurance industry. The Marine Insurance Act 1906 has not specified clearly about the solution; relevant English cases seem to render different decisions as to the payment recovered from the third party. The problem is caused by the co
Silvernanopartiklars toxicitet i miljön – har storleken betydelse? Antibakteriella silvernanopartiklar (AgNP) används i en rad olika konsumentprodukter, men toxicitet och miljöeffekter är inte särskilt välförstådda. Frisättning av silverjoner (Ag+) visade sig vara viktigt för toxiska effecter på bakterier. Dock verkar faktorer i det omgiv-ande mediet, t.ex. vatten, också ha stor effekt på beteenBy the investigation of pollution induced community tolerance (PICT), this study aimed at elucidating whether or not ionic silver (Ag+) and silver nanoparticles (AgNP) differ in toxic mode of action. Specifically, bacterial communities in natural water underwent a 6, 7 or 14 day selection for tolerance to Ag+ or citrate-coated 20 nm AgNPs. Bacterial protein synthesis was measured by [3H]-leucine i
OBJECTIVES: The aim of this study was to confirm prior modeling data suggesting that prasugrel 5 mg in low-body-weight (LBW) patients would be noninferior to prasugrel 10 mg in higher-body-weight (HBW) patients as assessed by maximal platelet aggregation (MPA). BACKGROUND: Prasugrel 10 mg reduced ischemic events compared with clopidogrel 75 mg but increased bleeding, particularly in LBW patients.
Mammalian dihydroorotate dehydrogenase (EC 1.3.99.11), the fourth enzyme of pyrimidine de novo synthesis is located in the mitochondrial inner membrane with functional connection to the respiratory chain. From the cDNA of rat liver dihydroorotate dehydrogenase cloned in our laboratory the first complete sequence of a mammalian enzyme was deduced. Two hydrophobic stretches centered around residues
Genetic factors play an important role in the pathogenesis of osteoporosis by affecting bone mineral density and other predictors of osteoporotic fracture risk such as ultrasound properties of bone and skeletal geometry. We previously identified a polymorphism of a Sp1 binding site in the Collagen Type 1 Alpha 1 gene (COLIA1) that has been associated with reduced BMD and an increased risk of osteo
Bacterial reverse transcriptases (RTs) are a large and diverse enzyme family. AbiA, AbiK and Abi-P2 are abortive infection system (Abi) RTs that mediate defense against bacteriophages. What sets Abi RTs apart from other RT enzymes is their ability to synthesize long DNA products of random sequences in a template- and primer-independent manner. Structures of AbiK and Abi-P2 representatives have rec
The presence of 5-methyluridine (m5U) at position 54 is a ubiquitous feature of most bacterial and eukaryotic elongator tRNAs. In this study, we have identified and characterized the TRM2 gene that encodes the tRNA(m5U54)methyltransferase, responsible for the formation of this modified nucleoside in Saccharomyces cerevisiae. Transfer RNA isolated from TRM2-disrupted yeast strains does not contain
