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Genome editing via CRISPR/Cas9 has rapidly become the tool of choice by virtue of its efficacy and ease of use. However, CRISPR/Cas9-mediated genome editing in clinically relevant human somatic cells remains untested. Here, we report CRISPR/Cas9 targeting of two clinically relevant genes, B2M and CCR5, in primary human CD4(+) T cells and CD34(+) hematopoietic stem and progenitor cells (HSPCs). Use

The generation of harmonics through a nonlinear mechanism driven by bunching at the fundamental has sparked interest as a path toward enhancing and extending the usefulness of an X-ray free-electron laser (FEL) facility. The sensitivity of the nonlinear harmonic generation to undulator imperfections, electron beam energy spread, peak current, and emittance is important in an evaluation of the proc

Objective: To describe anthropometric characteristics of participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: A cross-sectional analysis of baseline data of a European prospective cohort study. Subjects: This analysis includes study populations from 25 centres in nine European countries. The British populations comprised both a population-based and a 'he

Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as

The eumusc.net project is an initiative founded by the European Community and the European League Against Rheumatism. One aim of the project was to facilitate equal standards for musculoskeletal health across Europe. The aim of this work-package was to develop patient-centred and consensus based standards of care (SOC) for osteoarthritis (OA), which should be available in a professional and a pati

Today, the classification systems for myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) already incorporate cytogenetic and molecular genetic aberrations in an attempt to better reflect disease biology. However, in many MDS/AML patients no genetic aberrations have been identified yet, and even within some cytogenetically well-defined subclasses there is considerable clinical heterog

We calculated a simple indicator of food availability using data from 93 sites in 17 countries across contrasted agroecologies in sub-Saharan Africa (>13,000 farm households) and analyzed the drivers of variations in food availability. Crop production was the major source of energy, contributing 60% of food availability. The off-farm income contribution to food availability ranged from 12% for hou

Protein tyrosine phosphatase 1B (PTP1B) inhibits insulin signaling and, when overexpressed, plays a role in insulin resistance (Ahmad et al. 1997). We identified, in the 3' untranslated region of the PTP1B gene, a 1484insG variation that, in two different populations, is associated with several features of insulin resistance: among male individuals, higher values of the insulin resistance HOMA(IR)

(H2O)(N) clusters generated in a supersonic expansion source with N similar to 1000 were core ionized by synchrotron radiation, giving rise to core-level photoelectron and Auger electron spectra (AES), free from charging effects. The AES is interpreted as being intermediate between the molecular and solid water spectra showing broadened bands as well as a significant shoulder at high kinetic energ

Popular Abstract in Swedish Moderns rökning under graviditet och risk för medfödda missbildningar. Ungefär två procent av alla nyfödda föds med någon missbildning såpass allvarlig att den rapporteras till missbildningsregistret och/eller till det medicinska födelseregistret. Trots alla samhälleliga insatser för att minska rökningen (speciellt i samband med graviditet) så röker (1996) 16% av de grAbout two percent of Swedish newborn infants are born with a significant congenital malformations which is reported to the Swedish Registry of Congenital Malformations (RCM), and/or the Swedish Medical Birth Registry (MBR). In spite of persistent public health recommendations, about 16% of the Swedish pregnant women are smoking during pregnancy (1996). It is well known that maternal smoking during

Popular Abstract in Swedish Aerob kapacitet, i dagligt tal konditionen, är den maximala förmågan att utföra ett fysiskt arbete karaktäriserat av den maximala syreförbrukningen (V'O2max). Detta maximala arbete kan endast utföras en begränsad tid, till stor del beroende på en tilltagande anaerob metabolism, vilken bl.a. avspeglas som en ökning av utvädrat CO2 i lungorna. Längre tids arbete kan emellDifferent methods are proposed to assess the aerobic capacity. A novel scale, rating of perceived capacity (RPC) based on metabolic equivalents (METs) from 1 to 20, is presented. Selected MET values are linked to physical activities. Comparison of the rating with an exercise test in a group of women revealed that a correction based on age more accurately predicted the maximal exercise capacity. An

OBJECTIVES: To determine whether CA 125 measurement is superior to ultrasound imaging performed by an experienced examiner for discriminating between benign and malignant adnexal lesions, and to determine whether adding CA 125 to ultrasound examination improves diagnostic performance. METHODS: This is a prospective multicenter study (International Ovarian Tumor Analysis (IOTA) study) conducted in

För att vara patenterbar, måste varje uppfinning uppvisa ”utility” (användbarhet), som det kallas i USA, eller ”industrial application” (industriell tillämpbarhet), som det heter i Europa. Utöver ”nyhet”, ”uppfinningshöjd”, och kravet på en ”tillräcklig beskrivning av uppfinningen” i patentansökan utgör denna förutsättning både i USA och i Europa ett av de fyra grundläggande patenterbarhetskriteri

COVID Symptom Study Rapport vecka 27 (publicerad 2020-07-09) Innehåll Bakgrund 2 Metod 2 Etiskt godkännande 2 Aktuell status 2 10 postnummerområden med högst uppskattad förekomst den 6 juli . . . . . . . . . . . . . . . . . 4 10 postnummerområden med lägst uppskattad förekomst den 6 juli . . . . . . . . . . . . . . . . . . 5 Störst ökning senaste 7 dagarna . . . . . . . . . . . . . . . . . . . . .

https://www.covid19app.lu.se/sites/covid19app.lu.se/files/rapport_vecka27_coss_0.pdf - 2026-06-18

Prediction of the development of islet autoantibodies through integration of environmental, genetic, and metabolic markers OR I G I N A L AR T I C L E Prediction of the development of islet autoantibodies through integration of environmental, genetic, and metabolic markers Bobbie-Jo M. Webb-Robertson1,2 | Lisa M. Bramer3 | Bryan A. Stanfill3 | Sarah M. Reehl3 | Ernesto S. Nakayasu1 | Thomas O. Met

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-06/121_MP193_Webb-Robertson_JDiabetes_2020%20(2).pdf - 2026-06-18

The electrophysiological effects of pentisomide upon the intact human heart were evaluated using programmed stimulation and recording of intracardiac monophasic action potentials (MAP) in 17 patients with various ventricular arrhythmias. After i.v. administration of pentisomide, 85-135 mg, the atrial-His interval increased by 8 +/- 12 ms (p less than 0.05) during sinus rhythm and by 13 +/- 21 ms (

BACKGROUND: Although the association between cytosine-adenine-guanine (CAG) repeat length and age at onset of Huntington's disease is well known, improved prediction of onset would be advantageous for clinical trial design and prognostic counselling. We compared various measures for tracking progression and predicting conversion to manifest Huntington's disease.METHODS: In this prospective observa