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In this study alpha-lactalbumin was converted from the regular, native state to a folding variant with altered biological function. The folding variant was shown to induce apoptosis in tumor cells and immature cells, but healthy cells were resistant to this effect. Conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells) required partial unfolding of the protein and a specific fat

Germline mutations in the p53 tumor suppressor gene are associated with the Li-Fraumeni syndrome, characterized by childhood sarcoma, leukemia and early onset breast cancer and has occasionally been found also in familial breast-ovarian cancer. Most mutations found are of missense type and located in the central region of the gene (exons 5 to 8). In the present study, a germline p53 alteration was

The secretory leucocyte protease inhibitor, SLPI, is a low molecular weight inhibitor of proteases such as elastase and cathepsin G, which are released from leucocytes during phagocytosis. The purpose of this study was to show whether or not SLPI is produced in articular chondrocytes. In articular disorders, the protease-antiprotease balance is disturbed. For this reason it would be interesting to

Popular Abstract in Swedish Denna avhandling handlar om utveckling och tillämpning av metoder för jonstråleanalys av lätta ämnen (lättare än ungefär aluminium), framförallt vid en nukleär mikrosond. Vid en nukleär mikrosond accelereras tunga partiklar, t.ex. protoner, av en partikelaccelerator och fokuseras av ett speciellt magnetiskt linssystem ned till en storlek av ungefär 1 mikrometer. Denna sThis thesis treats the development of Ion Beam Analysis (IBA) methods, principally for the analysis of light elements at a nuclear microprobe (NMP). The light elements are in this context defined as those with an atomic number Z of less than approximately 13 (aluminium). The work reported is to a large extent based upon multiparameter methods. Several signals are acquired simultaneously, and the d

Popular Abstract in Swedish Arbetet i denna avhandling presenteras i 6 olika delarbeten (artiklar I-VI). Artiklarna I-III behandlar två olika enzymer som bryter ner cyklodextriner, vilka är ringformade molekyler med samma beståndsdelar som i stärkelse (dvs sammanlänkade glukosmolekyler). Dessa s.k. cyklodextrinaser kommer ursprungligen från två bakterier som har isolerats i varma källor på Island.Two putative cyclodextrinases (CDases) were amplified from two moderate thermophiles isolated in Iceland: Anoxybacillus flavithermus and Laceyella sacchari. They were cloned, expressed and characterized. The expression of the former was optimized in E. coli by using a solubility-enhancing tag, NusA, and tuning of inducer concentration in the expression strain Tuner(DE3). The CDases were optimally

The World Health Organization considers an aetiological classification of diabetes to be essential. The aim of this study was to evaluate whether HLA-DQB1 genotypes facilitate the classification of diabetes as compared with assessment of islet antibodies by investigating young adult diabetic patients. Blood samples were available at diagnosis for 1,872 (90%) of the 2,077 young adult patients (aged

(H2O)(N) clusters generated in a supersonic expansion source with N similar to 1000 were core ionized by synchrotron radiation, giving rise to core-level photoelectron and Auger electron spectra (AES), free from charging effects. The AES is interpreted as being intermediate between the molecular and solid water spectra showing broadened bands as well as a significant shoulder at high kinetic energ

NA44 uses a 512-channel Si pad array covering 1.5

Background: In addition to their possible direct biological effects, plasma carotenoids can be used as biochemical markers of fruit and vegetable consumption for identifying diet-disease associations in epidemiological studies. Few studies have compared levels of these carotenoids between countries in Europe. Objective: Our aim was to assess the variability of plasma carotenoid levels within the c

Titel ESG: varje bokstav för sig En studie som delar upp ESG komponenterna och undersöker dess inverkan på budpremien vid företagsförvärv Seminariedatum 2024-01-11 Kurs FEKH89, Examensarbete i finansiering på kandidatnivå, 15 Högskolepoäng Författarna Carl Andersson, Hampus Ottosson & Alexander Roos Handledare Anamaria Cociorva Nyckelord ESG-komponter, ESG-betyg, M&A, Förvärv, Syner

In 1963 the legislation on liquidation of entailed estates entered into force to liquidate the existing Swedish entailed estates. The entailed estates are to be liquidated when the last proprietor decease in accordance with Paragraph 3 of the legislation. Despite the principle rule, there is an exception in which an entailed estate doesn’t have to liquidate if it has an exceptional cultural value

I denna uppsats studeras statsminister Göran Perssons mediala kovändning – från buffel till ”Mys-Persson”. I takt med att vi tycker oss ha sett ett ökat fokus på privatpersoner, och då kanske främst inom politiken, tycker vi det är intressant att studera detta ämne. Som exempel här kan nämnas att Göran Persson varit med i TV-programmet ”Sen kväll med Luuk” och dansat med kossan Doris i SVTs barnpr

Cryptocurrencies are on the rise, with new financial assets, new frameworks need to be developed. This thesis sets out to the examine the GARCH(1,1), the bivariate-BEKK(1,1), and the Standard stochastic volatility model’s volatility forecasting performance on BTC/USD, where the bivariate model is estimated on both BTC/USD and ETH/USD closing price data. Furthermore, three loss functions are used t

This essay studies the relationship between institutional transparency and political trust. The study focuses on 27 countries in Europe. The existing theory regarding the relationship emphasizes different views. Some theorists claim that the two concepts are positively correlated whilst others claim the opposite. Hence, the study’s purpose: to test which of the theorists predict the correct outcom

Barnäktenskap är en angelägenhet som med internationella såväl som nationella medel motarbetas. Bland annat har Förenta nationerna (FN) uttalat att arbetet mot en nolltolerans mot barnäktenskap ska ses som en del av de globala målen som ska uppnås innan 2030. FN:s konvention om barnets rättigheter, allt oftast igenkänd som barnkonventionen, kopplar förbud mot barnäktenskap till fem olika rättighetChild marriage is a matter that is countered by international as well as national means. Among other things, the United Nations (UN) has stated that work towards a zero tolerance for child marriage should be seen as part of the global goals to be achieved by 2030. The UN Convention on the Rights of the Child, most often recognized as the Convention on the Rights of the Child, links ban on child ma

The RAI gene is also known as iASPP and PPP1R13L. Recent investigations have shown that the region encompassing RAI is important for the development of cancer in young and middle-aged persons. It has been speculated that the RAI product induces apoptosis by blocking NF-kappaB or inhibits apoptosis by blocking p53. Either way the gene could influence the survival of precancerous lesions. Here we re

Many cellular proteins are methylated on lysine residues and this has been most intensively studied for histone proteins. Lysine methylations on non-histone proteins are also frequent, but in most cases the functional significance of the methylation event, as well as the identity of the responsible lysine (K) specific methyltransferase (KMT), remain unknown. Several recently discovered KMTs belong