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Apelin, a ligand of the APJ receptor, is overexpressed in several human cancers and plays an important role in tumor angiogenesis and growth in various experimental systems. We investigated the role of apelin signaling in the malignant behavior of cutaneous melanoma. Murine B16 and human A375 melanoma cell lines were stably transfected with apelin encoding or control vectors. Apelin overexpression

The Nordic countries offer an ideal case study of the COVID-19 pandemic due to their comparability, high data quality, and variable mitigations. We investigated the age- and sex-specific mortality patterns during 2020–2021 for the five Nordic countries and analysed the total age- and sex-adjusted excess deaths, ratios of actual to expected death rates, and age-standardized excess death estimates.

BACKGROUND: Chronic low-grade inflammation may play a role in the pathophysiology of depression, at least in a subset of patients. High-sensitivity C-reactive protein (hs-CRP) has been used to define an inflamed subgroup of depression with specific clinical characteristics and symptoms. In this study we investigated biochemical and clinical characteristics in patients with difficult-to-treat depre

Melanoma in advanced stages is one of the most aggressive tumors and the deadliest of skin cancers. To date, the histopathological staging focuses on tumor thickness, and clinical staging is a major estimate of the clinical behavior of primary melanoma. Here we report on an observational study with in‐depth molecular profiling at the protein level including post-translational modifications (PTMs)

In this study, we demonstrate an acoustofluidic device that enables single-file focusing of submicron particles and bacteria using a two-dimensional (2D) acoustic standing wave. The device consists of a 100 μm × 100 μm square channel that supports 2D particle focusing in the channel center at an actuation frequency of 7.39 MHz. This higher actuation frequency compared with conventional bulk acoust

Arbuscular mycorrhizal fungi (AMF) are considered ecosystem engineers, but the interactions of their mycelium with their immediate surroundings are largely unknown. In this study, we used microfluidic chips, simulating artificial soil structures, to study foraging strategies and habitat modification of Rhizophagus irregularis symbiotically associated to carrot roots. AMF hyphae foraged over long d

The Concordance Index (C-index) is a commonly used metric in Survival Analysis for evaluating the performance of a prediction model. In this paper, we propose a decomposition of the C-index into a weighted harmonic mean of two quantities: one for ranking observed events versus other observed events, and the other for ranking observed events versus censored cases. This decomposition enables a finer

In the afterburner assembled with an air-cooled bluff-body flameholder, cooling air is directly injected into the recirculation zone behind the bluff-body, which can reduce the local temperature and increase the oxygen concentration of the gas mixture in the wake of the bluff-body, thereby affecting the total pressure loss and combustion characteristics. To better understand the flow and combustio

We report on local nowcasting (short-term forecasting) of coronavirus disease (COVID-19) hospitalizations based on syndromic (symptom) data recorded in regular healthcare routines in Östergötland County (population ≈465,000), Sweden, early in the pandemic, when broad laboratory testing was unavailable. Daily nowcasts were supplied to the local healthcare management based on analyses of the time la

The discovery that the CRISPR/Cas9 system could be used for genome editing purposes represented a major breakthrough in the field. This advancement has notably facilitated the introduction or correction of disease-specific mutations in healthy or disease stem cell lines respectively; therefore, easing disease modeling studies in combination with differentiation protocols. For many years, variabili

Avtalsfriheten är en grundläggande princip i svensk rätt som erbjuder avtalsparterna en rätt att välja hur ett avtal ska slutas. Tvingande lagregler kan dock sätta upp vissa förutsättningar för hur ett giltigt avtal ska se ut. Ett tillvägagångssätt är att i lag uppställa olika typer av formkrav. En typ av formkrav är det skriftliga formkravet som uppställs för bland annat prorogationsavtal. Det inThe principle of contractual freedom is a centrepiece in Swedish law that enable the parties to decide how to conclude an agreement. Mandatory legislation however demand sometimes that certain conditions must exist for a valid agreement. One course of action is to legislate for certain formal requirements. One kind of formal requirements is that the agreement must be in written form. This requirem

I retailbranschen krävs ett fokus på detaljer, och med snabba förändringar som en dominerande faktor, behöver dessa detaljer ständigt kvalitetsförbättras. I den allt hårdnande konkurrensen behövs ledare och medarbetare som ständigt tänker på organisationens behov. Problemet för detaljhandelns centraliserade butikskedjor kan vara att lyckas förankra förändring och kvalitetsförbättring för butiken i

Bakgrund: Under en graviditet genomgår kroppen stora förändringar där fysiska och psykiska faktorer kan påverka gravida kvinnors fysiska aktivitet. Gravida kvinnor rekommenderas medelintensiv fysisk aktivitet 150 minuter per vecka och träning under graviditet kan förebygga och underlätta olika graviditetsrelaterade besvär. Få studier har dock kartlagt i hur stor utsträckning gravida kvinnor når upBackground: During a pregnancy the body goes through changes that can affect pregnant women ́s physical activity level. Pregnant women are recommended to be physically active for 150 minutes per week on a medium intensity. Training during pregnancy can prevent and lighten different pregnancy related issues. Few studies have been made to investigate if pregnant women reach the physical activity rec

Bakgrund: Under en graviditet genomgår kroppen stora förändringar där fysiska och psykiska faktorer kan påverka gravida kvinnors fysiska aktivitet. Gravida kvinnor rekommenderas medelintensiv fysisk aktivitet 150 minuter per vecka och träning under graviditet kan förebygga och underlätta olika graviditetsrelaterade besvär. Få studier har dock kartlagt i hur stor utsträckning gravida kvinnor når up

Fåmansföretagsreglerna i 57 kap. inkomstskattelagen (1999:1229) innehåller särregler för hur ersättning till aktiva ägare i fåmansföretag ska delas upp mellan avkastning på investerat kapital och ersättning för utfört arbete. Reg-lernas primära syfte är att förhindra inkomstomvandling för att på så sätt uppnå en neutral beskattning av skattskyldiga. Utdelning och kapitalvinst upp till ett visst beThe close company rules in Chapter 57 of the Swedish Income Tax Act (1999:1229) contain special provisions on how monetary compensation to active owners in close companies is to be divided between return on invest-ed capital and remuneration for performed work. The primary purpose of these rules is to prevent income conversion, and thereby achieving neutral taxation of taxpayers. Dividends and cap

In this work company announcements of blockchain name changes are empirically analysed to obtain a sense of how markets value the blockchain technology. This “blockchain effect” is analysed using an event study in order to calculate cumulative abnormal returns for multiple event windows. The “blockchain effect” generates cumulative average abnormal return of 58 percent for the five days surroundin

Utvecklingen av den artificiella intelligensen anses utgöra den fjärde industri-ella revolutionen. Den tekniska utvecklingen har emellertid givit upphov till ett antal komplexa frågor vad avser frågan om ansvar. Uppsatsen har som syfte att utreda om en biltillverkare kan hållas ansvarig enligt PAL för skador orsa-kade av den artificiella intelligensen i en autonom bil. Det råder strikt ansvar i PAThe development of artificial intelligence has been described as the fourth in-dustrial revolution. However, technological developments may result in com-plex questions with regard to the issue of liability. The aim of this thesis is to analyze whether a vehicle manufacturer can be held liable for damages caused by the artificial intelligence according to the Product Liability Act (PAL). The legal

Bakgrund Ridsport är en av Sveriges största sporter med en stor variation av discipliner och utövare i alla åldrar. Trots att prevalensen för ländryggssmärta inom ridsporten misstänks vara hög så saknas kartläggning av problematiken, dess orsaker, konsekvenser och åtgärder. Syfte/frågeställningar Syftet med studien var att kartlägga prevalensen av ländryggssmärta och smärtans påverkan på det dagli

I denna rapport jämförs två olika grundläggningsmetoder med fokus på deras praktiska tillämpning och tillhörande klimatpåverkan i urbana miljöer. Syftet är att undersöka, belysa och öka kunskapen om mindre beprövade grundläggningsmetoder i Sverige, samt öka förståelsen för deras potentiella fördelar. Jämförelsen fokuserar på hur en permanent bärande sekantpålevägg utförd med CCFA-metoden kan vara This report presents a comparative analysis of two foundation methods, focusing on their practical implementation and environmental impact in urban environments. The aim is to examine and enhance understanding of less commonly used foundation techniques in Sweden, while also evaluating their potential advantages. The comparison specifically investigates whether a permanently load-bearing secant pi

This study has examined how young people in out-of-home care, specifically special youth homes in Sweden (SiS), describe their life situation and their ability to make their voices heard during care. We used a qualitative document analysis approach, collecting 40 stories from young persons in secure residential care from three different sources. To deepen our understanding, we used Erving Goffman´