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Human alpha-1-antitrypsin (AAT) encoded by the SERPINA1 gene, is an acute phase glycoprotein that regulates inflammatory responses via both protease inhibitory and non-inhibitory activities. We previously reported that AAT controls ATP-induced IL-1β release from human mononuclear cells by stimulating the release of small bioactive molecules. In the current study, we aimed to elucidate the identity
Background: Metabolic positron emission tomography/computed tomography (PET/CT) parameters describing tumour activity contain valuable prognostic information, but to perform the measurements manually leads to both intra- and inter-reader variability and is too time-consuming in clinical practice. The use of modern artificial intelligence-based methods offers new possibilities for automated and obj
This article addresses the gap in knowledge about how new digital technology affects decision making and social caseworkers’ professionalism. The aim is to enhance the understanding of how digital discretion—as a result of introducing automated decision making (ADM) in social assistance—affects the roles, work processes and professional judgements of social caseworkers in the provision of social a
Sea salt aerosol particles are highly abundant in the atmosphere and play important roles in the global radiative balance. After influence from continental air, they are typically composed of Na+, Cl-, NH4+, and SO42- and organics. Analogous particle systems are often studied in laboratory settings by atomizing and drying particles from a solution. Here, we present evidence that such laboratory st
In order to meet the increasing needs of housing and services in urban areas, cities are densified. When densifying a city, it is important to provide good living conditions while maintaining a low environmental impact. To ensure this, the urban planning process should include simulations of e.g. noise and daylight conditions. In this paper we describe a newly started projected directed towards th
Knowledge of human fetal blood development and how it differs from adult blood is highly relevant to our understanding of congenital blood and immune disorders and childhood leukemia, of which the latter can originate in utero. Blood formation occurs in waves that overlap in time and space, adding to heterogeneity, which necessitates single-cell approaches. Here, a combined single-cell immunopheno
Land subsidence, a silent death, occurs due to various factors like significant reduction in groundwater (GW) levels. It is a widespread phenomenon with irreparable consequences on buildings, infrastructures, and, in severe cases, groundwater aquifers. This study aims to assess the impact of river flow on the acceleration and control of land subsidence in an arid and semi-arid region. To achieve t
Despite low or undetectable plasma viral load, people living with HIV-2 (PLWH2) typically progress toward AIDS. The driving forces behind HIV-2 disease progression and the role of viremia are still not known, but low-level replication in tissues is believed to play a role. To investigate the impact of viremic and aviremic HIV-2 infection on target and bystander cell pathology, we used data-indepen
In this chapter we present a non-destructive method for characterizing buried interfaces with high depth resolution combining X-rays standing wave and photoemission electron spectroscopy. This method incorporates the power of the X-rays photoelectron spectroscopy, which is a surface sensitive technique in the nanometer and sub-nanometer regime, with the depth selectivity of X-ray standing wave. Th
During the early modern period Swedish society was structured by a variety of hierarchies, and the principle of filial deference, or the obedience and recognition children–young or adult–were expected to show their parents, was more or less absolute. These ideas of family hierarchy influenced marriage laws and the formal rules of who was allowed to marry whom. During the 1700s the number of applic
The aim of this qualitative study has been to analyze how young adults with Yugoslavian background form and sustain relations across national borders. The study covers second-generation migrants (hereby titled as young adults with Yugoslavian background) who are born in Sweden, with Yugoslavian born parents that came to Sweden as refugees between the years of 1990-1998. Ten semi-structured intervi
CO2 is the most important greenhouse gas in terms of radiative forcing, and it is therefore highly important that we can track our emissions and the effectiveness of carbon sequestration measures. While the national carbon inventories can be highly accurate, there is general conflict of interest, as national carbon inventories are bottom up estimates in part based on self-reportings from private a
This thesis investigates how individuals in Sweden perceive the sustainability of electric car usage, using the Triple Bottom Line framework, which encompasses environmental, economic, and social dimensions. The primary aim is to gain insight into the genuine sustainability intentions of electric car users and to understand how they interpret sustainability not only in terms of environmental i
This thesis explores how Swedish civil society organisations (CSOs) navigate transnational partnerships under civic space restrictions in India. Against the backdrop of the Foreign Contribution (Regulation) Act (FCRA) and shrinking Swedish aid, the study analyses how CSOs adapt to legal, political, and relational constraints. Drawing on four semi-structured interviews and guided by the concepts of
The study aims to gain an increased understanding of and insight into CBT psychotherapists ́ experiences of what is effective in psychotherapeutic treatment. A perspective of interest based on the fact that psychotherapists ́ experiences of what is effectivehave not previously been taken into account in research, that in the therapist ́s everyday life there may be a clash between theory and practi
Följande uppsats analyserar det straffrättsliga ansvaret vid olyckor orsakade av självkörande fordon. Dessa självkörande fordon styrs av avancerade artifi-ciella algoritmer som fattar autonoma beslut, vilket utmanar straffrättens grundläggande krav och principer. Bland annat blir maximet ”nulla poena sine culpa” (inget straff utan skuld) lidande när beslutsprocessen i gärningsögon-blicket saknar tThe following thesis analyzes criminal liability in accidents caused by self-driving vehicles. These autonomous vehicles are governed by advanced artifi-cial algorithms that make autonomous decisions, which challenges the funda-mental requirements and principles of criminal law. Among other things, the maxim "nulla poena sine culpa" (no punishment without guilt) suffers when the decision
This study examines the relationship between civil society engagement and party choice between the Social Democrats and the Sweden Democrats in the 2022 Swedish general election. Drawing on prior research on civil society, political participation and changes in the Swedish party system, the study adopts a mixed-methods design. The quantitative analysis uses data from the 2022 Swedish National SOM
