Filtyp
The search for new cancer biomarkers is essential for fundamental research, diagnostics, as well as for patient treatment and monitoring. Whereas most cancer biomarkers are biomolecules, an increasing number of studies show that mechanical cues are promising biomarker candidates. Although cell deformability has been shown to be a possible cancer biomarker, cellular forces as cancer biomarkers have
Most proteins have evolved to function optimally in aqueous environments, and the interactions between protein and water therefore play a fundamental role in the stability, dynamics, and function of proteins. Although we understand many details of water, we understand much less about the protein-water interface. In this thesis we use molecular dynamics (MD) simulations to cast light on many struct
Background--Long-term disease progression after myocardial infarction (MI) is inadequately understood. We evaluated the pattern and angiographic properties (culprit lesion [CL]/non-CL [NCL]) of recurrent MI (re-MI) in a large real-world patient population. Methods and Results--Our observational study used prospectively collected data in 108 615 patients with first-occurrence MI enrolled in the SWE
Deep learning has the potential to drastically increase the accuracy and efficiency of prostate cancer diagnosis, which would be of uttermost use. Today the diagnosis is determined manually from H&E stained specimens using a light microscope. In this paper several different approaches based on convolutional neural networks for prostate cancer classification are presented and compared, using th
The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the
To provide practical guidelines for the cytopathologic diagnosis of malignant mesothelioma.
Popular Abstract in Swedish Denna avhandling handlar om en grupp narkotikamissbrukare som gjort självmordsförsök. Såväl självmord som självmordsförsök är betydligt vanligare bland narkotikamissbrukare jämfört med totalbefolkningen. Bland vårdade narkotikamissbrukare är det mellan 19 till 47 procent som gjort självmordsförsök. Det höga självmordsförsökstalet bland narkotikamissbrukare förklaras oftThe aim of this thesis is to describe suicide attempts in a group of drug abusers who previously had received treatment of their addiction. Another aim is to interpret and analyse the life situations that the individual associates with the suicide attempt. The dissertation is based on interviews conducted on two occasions with 92 drug abusers, 62 men and 30 women. The majority of the drug abusers
To provide practical guidelines for the cytopathologic diagnosis of malignant mesothelioma (MM). Cytopathologists involved in the International Mesothelioma Interest Group (IMIG) and the International Academy of Cytology (IAC), who have an interest in the field contributed to this update. Reference material includes peer-reviewed publications and textbooks. This article is the result of discussion
OBJECTIVES: Health utilities derived from answers to generic health-related quality of life (HRQoL) questionnaires such as the EuroQol 5-Dimensions (EQ-5D) are often used in cost-utility analyses (CUAs) of new and expensive treatments. Different preference sets (tariffs) used in the computation of utility values and quality-adjusted life-years (QALYs) from questionnaire responses (health states) y
Interfacial structures on the nanoscale are crucial for a wide field of applications ranging from biological membranes in life sciences through organic solar cells and industrial coatings in soft matter to hard matter structures. The latter include thin film coatings and materials such as magnetic nanoparticles and topological structures like magnetic skyrmions. Advancing such application rests on
A major challenge hampering the industrial and biological exploitation of lipases is the self-limiting effect of the lipolytic reaction. Defying sustained attention throughout history, the influence of lipase catalysed lipolysis on the internal structure of thin triglyceride films has proved elusive. An in-depth understanding of the lipolysis process at the triglycerides/aqueous interface will ass
Polycyclic aromatic hydrocarbons (PAHs) of molecular mass (MM) 302 Da comprise numerous structural isomers that are of high concern for human health. Because of their multiplicity, low abundance in the environment, and limited availability of authentic standards, their occurrence, composition, and environmental health risk remain not well characterized. Here we extend the characterization of MM 30
Consumers are increasingly becoming aware of the abusive exploitation of workers in some of the factories in the development countries that are contracted to produce exports to the European market. Thus, some of the consumers try to promote the enforcement of ethical business practices globally by using their buying behaviour. In effect, the ethical consumers prefer to buy ethically sound goods to
Hypothesis: Sponge phase (L3) lipid nanoparticles (L3-NPs) have been shown to have large potential for the encapsulation of biomolecules, such as enzymes, with applications in food and pharmaceutical science. In this study, we introduce new formulations of L3-NPs including the phospholipids dioleoylphosphatidylcholine (DOPC) and dioleoyltrimethylammonium propane (DOTAP). The interaction of these n
A search for a hypothetical heavy scalar particle, X, decaying into a singlet scalar particle, S, and a Standard Model Higgs boson, H, using 140 fb−1 of proton-proton collision data at the centre-of-mass energy of 13 TeV recorded with the ATLAS detector at the LHC is presented. The explored mass range is 300 ≤ mX ≤ 1000 GeV and 170 ≤ mS ≤ 500 GeV. The signature of this search is one or two leptons
Northern mires are significant natural sources of atmospheric methane (CH4), yet estimating CH4 emissions remains challenging due to their complex spatio-temporal dynamics. While eddy covariance (EC) measurements provide valuable insights into ecosystem-scale CH4 fluxes (FCH4) over mire areas typically < 0.05 km², the predictability of FCH4 at the mesoscale (∼0.5 – 20 km²) of a mire complex based
Non-exhaust emissions from the wear of brakes, tyres, and roads have become an increasing concern in recent years, already surpassing exhaust emissions by mass in many countries. However, there is a lack of studies in the scientific literature on test methods that include both real tyre and road materials. This is crucial for accurately replicating the tribological mechanisms and resulting emissio
Popular Abstract in Swedish Luften omkring oss består inte bara av gaser. I den finns det mängder av små partiklar. De partiklar som står i fokus i den här avhandlingen är mindre än 10 μm, vilket endast är en femtedel av ett hårstrås diameter. Dessa partiklar är tillräckligt små för att kunna förflyttas långa sträckor i atmosfären och har dessutom visat sig påverka människors hälsa negativt. Man hAerosol particles are found in the whole troposphere. Research regarding these particles has gained increased attention because of the effect the particles have on both health and climate. In the atmosphere, aerosol particles scatter incoming solar radiation and this has a cooling effect on the Earth’s climate. But there are particles, especially those containing soot, which can absorb sun light a
