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In Statistical Shape Modeling, a dense correspondence between the shapes in the training set must be established. Traditionally this has been done by hand, a process that commonly requires a lot of work and is difficult, especially in 3D. In recent years there has been a lot of work on automatic construction of Shape Models. In recent papers (Davies et al., Medical Image Computing and Computer-Ass
When planning new environments, such as homes and workplaces, for the physically disabled it is important to encourage active participation from all those involved. In a research programme initiated at the Lund Institute of Technology, Sweden, a new planning method is being introduced which utilizes computer-aided design as a planning tool. This tool supports and activates the understanding and pa
Cholesterol-rich clusters of SNARE (soluble NSF attachment protein receptor) proteins have been implicated as being important for exocytosis. Here we demonstrate the significance of cholesterol for normal biphasic insulin secretion in mouse beta cells by removal of cholesterol from the plasma membrane using methyl-beta-cyclodextrin (MBCD). Maximal inhibition of insulin secretion in static incubati
EU:s deponeringsdirektiv har medfört ökade krav på deponier. Mängden deponerat organiskt material har begränsats kraftigt och deponiernas inre skall nu vara så torrt som möjligt. Konsekvenserna av detta är ännu inte helt kända. Fläskebodeponin, den deponi som varit i drift längst av de få svenska deponier som är konstruerade enligt direktivet, har här fungerat som ett exempel på framtidens depoThe European landfill directive increases demands on landfills. The amount of organic matter being landfilled is restricted and landfills should be as dry as possible. The consequences of these changes are not yet fully understood. In this study the first landfill in Sweden to be constructed according to the directive, Fläskebo, has served as an example of future landfills. Its leachate has bee
The MUI framework supports composition of ad-hoc applications from services available on ad-hoc networked devices. MUI is an open-ended framework, relying on migrating user interfaces and standardized data formats for connecting services, allowing existing devices to be connected to new devices without needing any pre-defined knowledge of their services. We illustrate the benefits of the approach
Recent studies in Drosophila have shown that heparan sulfate proteoglycans (HSPGs) are required for Wingless (Wg/Wnt) signaling. In addition, genetic and phenotypic analyses have implicated the glypican gene daily in this process. Here, we report the identification of another Drosophila glypican gene, daily-like (dly) and show that it is also involved in Wg signaling. Inhibition of dly gene activi
Gas turbine systems are predominantly designed to be fuelled with gaseous fuels within a limited Wobbe index range (typically HHV=45-55 MJ/Nm3 or 1200-1480 Btu/scf). When low calorific fuel gases are fired, the engine will be forced to operate outside its design envelope. The added mass flow will typically raise the cycle pressure ratio and in two-shaft designs also raise the gas generator shaft s
Detta arbete kick-startar AI (artificiell intelligens) för ledningsunderhåll i VA-branschen i Sverige. Arbetet med befintliga VA-nät är idag främst reaktivt; man reparerar läckor vartefter man blir varse dem, ibland till stora kostnader om läckan är omfattande och akut. Med denna artikel vill vi sätta fokus på proaktivt arbete med ledningsnät och diskutera riskanalys inom området. En ANN-modell soThis work kick-starts AI (artificial intelligence) for pipe management among Swedish water utilities. The current work with pipe management is mainly reactive; leaks are repaired after they are detected, sometimes with large costs if the leakage is extensive and critical. With this article, we want to focus on proactive pipe network management and discuss risk analysis in the field. A previously d
The design of technologies, built environments, products, or services can result in inequalities, exclusion, and discrimination, possibly because designers–often unintentionally–reproduce social norms through their designs. This strongly relates to engineering and design educations, preparing future professionals and contributing to sustainable societies. The aim of this paper is to introduce and
Background and aims: PPARGC1A encodes PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1-α), a central regulator of energy metabolism and mitochondrial function. A common polymorphism in PPARGC1A (rs8192678, C/T, Gly482Ser) has been associated with obesity and related metabolic disorders, but no published functional studies have investigated direct allele-specific effects in adipoc
Breathlessness is common in the general population. Existing data were obtained primarily with the uni-dimensional modified Medical Research Council breathlessness scale (mMRC) that does not assess intensities of unpleasantness nor physical, emotional and affective dimensions. The aim of this research was to determine the prevalence and intensity of these dimensions of breathlessness in elderly ma
Forensic psychiatric patients constitute a heterogeneous patient group, with common comorbidity within the externalizing spectrum. Increased knowledge on early antecedents in the pathway to severe mental illness and criminality is needed. In this study, we investigated early onset externalizing behaviors in three groups of forensic psychiatric patients 1) patients without contact with child and ad
