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BACKGROUND: This study aimed to evaluate the prevalence of pathogenic/likely pathogenic cardiomyopathy variant carriers in a multiancestry US population and examine the risk of adverse clinical outcomes. METHODS: This retrospective cohort study included multiancestry US adults aged ≥18 years with sequencing data from the All of Us Research Program. Pathogenic/likely pathogenic variants in cardiomy

Dilated cardiomyopathy (DCM) is a leading cause of heart failure and cardiac transplantation. We report a genome-wide association study and multi-trait analysis of DCM (14,256 cases) and three left ventricular traits (36,203 UK Biobank participants). We identified 80 genomic risk loci and prioritized 62 putative effector genes, including several with rare variant DCM associations (MAP3K7, NEDD4L a

The compositions of alternative jet fuels can vary radically, and the consequences of these differences are a subject of ongoing investigation. Numerical combustion simulations are vital to this research and require chemical reaction mechanisms that efficiently and accurately capture the chemical pathways of combustion. Here, we present the recently developed Z79 collection of small pathway-centri

Ribbed channel flows play a crucial role in various engineering systems where turbulence enhancement and improved heat transfer are required, such as in turbine blade cooling and combustor wall applications. Numerical simulations have emerged as an essential tool for analyzing the intricate turbulence dynamics and flow separation phenomena, which are fundamental for optimizing the channel performa

Background: Pulmonary hypertension (PH) is frequent in patients with heart failure and reduced ejection fraction (HFrEF) with 2 different phenotypes: isolated postcapillary PH (IpcPH) and, with the worst prognosis, combined pre- and postcapillary PH (CpcPH). The aims of the present echocardiography study were to investigate (1) the ability to identify PH phenotype in patients with HFrEF using the

Financial accounting is a process that goes from the company’s transactions, through the accounting system and production of financial statements, to the use and analysis of the information by external parties. The analysis of financial statements is the basis for many important decisions. This book explains the fundamental role of financial accounting in the economy.The book covers both technical

Regular exercise leads to widespread salutary effects, and there is increasing recognition that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited data exist regarding the plasma proteomic changes that occur in response to regular exercise. Here, we perform large-scale plasma proteomic profiling in 654 healthy human study participants before and after a supe

Aims/hypotheses: Smoking and use of smokeless tobacco (snus) are associated with an increased risk of type 2 diabetes. We investigated whether smoking and snus use increase the risk of latent autoimmune diabetes in adults (LADA) and elucidated potential interaction with HLA high-risk genotypes. Methods: Analyses were based on Swedish case–control data (collected 2010–2019) with incident cases of L

During epileptic seizures, neuronal network activity is hyper synchronized whereby GABAergic parvalbumin-interneurons may have a key role. Previous studies have mostly utilized 4-aminopyridine to induce epileptiform discharges in brain slices from healthy animals. However, it is not clear if the seizure-triggering ability of parvalbumin-interneurons also holds true without the use of external conv

The Japanese avant-garde dance form butoh, founded by Hijikata Tatsumi in the late 1950s, is known for its marked physicality. The choreographic methodology of butoh, however, is not focused primarily on instructing the dancers how to move their bodies. Instead, the dancers work with verbal and mental imagery to transform into butoh-tai, the “butoh body,” a special form of embodiment from which th

Background Elevated troponin levels are a sensitive biomarker for cardiac injury. The quick and reliable prediction of troponin elevation for patients with chest pain from readily available ECGs may pose a valuable time-saving diagnostic tool during decision-making concerning this patient population. Methods and results The data used included 15 856 ECGs from patients presenting to the emergency r

Background: The incorporation of artificial intelligence (AI) into point-of-care ultrasound (POCUS) platforms has rapidly increased. The number of B-lines present on lung ultrasound (LUS) serve as a useful tool for the assessment of pulmonary congestion. Interpretation, however, requires experience and therefore AI automation has been pursued. This study aimed to test the agreement between the AI

Lean, premixed, swirl-stabilized flames are widely used in modern Dry Low Emissions gas turbine combustors; however, the turbulent combustion process under those conditions is known to be extremely sensitive and prone to instabilities. Numerical simulations can be a valuable tool in predicting the effects of alternative fuels; however, the sensitivity of the results to different models ought to be

The combustion of conventional Jet A, alongside two alternative jet fuels, C1 and C5, is simulated with Large Eddy Simulations (LES) in a generic single-cup spray combustor during idle and cruise conditions. The spray is modeled using Lagrangian particle tracking and the combustion chemistry of each fuel is modeled by skeletal reaction mechanisms. The volatility and atomizability of each fuel dire

In numerical combustion research, accurate chemical reaction mechanisms for heavy hydrocarbons are essential to investigate the flame dynamics of Sustainable Aviation Fuels (SAF) relative to conventional jet fuels. However, accounting for hundreds or thousands of reactions makes Finite-Rate Chemistry (FRC) Large Eddy Simulations (LES) impractical for realistic engineering scenarios. In the present

In North and East Syria—also known as Rojava—the convergence of war, politics, and environmental challenges presents a complex and pressing reality. This blog is dedicated to exploring these interlinked issues, highlighting how conflict and ecological degradation are deeply connected, and how these dynamics affect communities in varied and unequal ways.

This study investigated the spatial dynamics of bark beetle infestations and their relationships with risk factors in south-eastern Swedish forests during the years 2018–2020, highlighting the importance of spatial heterogeneity of risk factors, particularly under climate change. First, global Random Forest (RF) models were developed to examine the relationships between bark beetle infestations an

We propose a multimodal deep learning framework for automated analysis ofcat–human communication, integrating acoustic, visual, and tactile signals throughtransformer-based fusion. Using the largest expert-annotated dataset of its kindand interdisciplinary collaboration, we combine semi-supervised learning withethological and phonetic expertise to detect subtle behavioural and phonetic cues,enable

Den växande efterfrågan på hållbar och miljövänlig elproduktion, tillsammans med globala osäkerheter, understryker behovet för nationer att uppnå självförsörjande produktion av el. Kärnkraft, som står för cirka 30% av Sveriges elproduktion, spelar en avgörande roll i att leverera fossilfri el. Eftersom många kärnkraftverk närmar sig slutet av sin planerade livslängd är det avgörande att förlänga dThe growing demand for sustainable electricity production, coupled with global uncertainties, highlights the need for nations to achieve self-sufficiency in producing electricity. Nuclear power, which provides around 30% of Sweden's electricity, plays a critical role in delivering fossil-free electricity. As many nuclear plants are near the end of their designated lifespans, extending their operat