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Background and objectives: Arterial stiffness plays a significant role in the development and progression of adverse cardiovascular events and all-cause mortality. This observational study aims to explore the relationship between six acute phase proteins namely, ceruloplasmin, alpha-1-antitrypsin, orosomucoid, haptoglobin, complement C3 and C-reactive protein (CRP), and carotid-femoral pulse wave

Cell entry of Simian Virus 40 (SV40) involves caveolar/lipid raft-mediated endocytosis, vesicular transport to the endoplasmic reticulum (ER), translocation into the cytosol, and import into the nucleus. We analyzed the effects of ER-associated processes and factors on infection and on isolated viruses and found that SV40 makes use of the thiol-disulfide oxidoreductases, ERp57 and PDI, as well as

Cellobiose dehydrogenase (CDH) is a versatile bioelectrocatalyst lately at focus due to its sugar oxidising properties in combination with its inherent ability for direct electron transfer communication with electrodes making it possible to be used in bioanodes in the enzymatic fuel cells (EFCs), self-powered biosensors, and biosupercapacitors. During the last 20 years, many new nanomaterials and

A fitting-attitude analysis which understands value in terms of reasons and pro- and con-attitudes allows limited wriggle room if it is to respect a radical division between good and good-for. Essentially, its proponents can either introduce two different normative notions, one relating to good and the other to good-for, or distinguish two kinds of attitude, one corresponding to the analysis of go

Empirical software engineering research aims to generate prescriptive knowledge that can help software engineers improve their work and overcome their challenges, but deriving these insights from real-world problems can be challenging. In this paper, we promote design science as an effective way to produce and communicate prescriptive knowledge. We propose using a visual abstract template to commu

The financial position of the medical insurance system of Japanese government has been worsened recently, and thus the Ministry of Health, Labor and Welfare has prompted the medical reforms to reconstruct the financial balance of the medical insurance system. As one of these efforts, a fixed payment system for medical services based on “DPC” (Diagnosis Procedure Combination) was introduced to a nu

This contribution presents a modeling and optimization method for multi-column counter-current purification (MCSGP) processes. The model is based on conventional column models and by using the symmetric and cyclic steady state characteristics of the process a single column analog model was developed. The model have been used for dynamic optimization of the MCSGP process. The optimization was based

Objectives: To describe the process and outcomes of using a new evidence base to develop scientific guidelines that specify the type and minimum dose of exercise necessary to improve fitness and cardiometabolic health in adults with spinal cord injury (SCI). Setting: International. Methods: Using Appraisal of Guidelines, Research and Evaluation (AGREE) II reporting criteria, steps included (a) det

To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLADRB5 (odds ratio (

Carbon fiber reinforced plastics, CFRP, are attractive materials not only because of their strength and stiffness but also because of their electrical conductivity and high thermal conductivity and diffusivity. One application where induction heating of CFRP is particularly interesting is tools for fast thermal cycling, beneficial in many industrial processes, for example in composite manufacturin

Characterization of different transport phenomena through porous media represents a key factor to improve mechanical or electrical properties of materials. Porous materials have several applications in different fields such as geological sciences, energy sciences or biological applications. Considering the difficulty to carry out experimental studies in porous media, these transport phenomena are

We study the effects of self-consistency and vertex corrections on different GW-based approximations for model systems of interacting electrons. For dealing with the most general case, we use the Keldysh time-loop contour formalism to evaluate the single-particle Green's functions. We provide the formal extension of Hedin's GW equations for the Green's function in the Keldysh formalism. We show an

Coalescence during emulsification has a significant effect on the outcome of the process, especially for the high volume fractions of disperse phase common in food and pharmaceutical processing. Controlling emulsification requires that the extent of coalescence during different conditions can be quantified. The step-down technique is the most commonly used method for measuring coalescence frequenc

The international community has been engaged in capacity development for decades, sometimes under different names or with a slightly different focus. So far, these efforts have failed to bring significant and sustainable change. The Sendai Framework for Disaster Risk Reduction 2015–2030 specifies capacity development as the means to reduce disaster losses substantially. The purpose of this paper i

The four-stroke engine was invented by Nikolaus Otto during the second half of the 19th century. Although a lot of technological improvements have been made over the years, the operating principle with four-strokes remains the same. The need and desire of engines with even higher fuel-efficiency is a motivation to study alternative engine concepts. This thesis presents studies of the Double Compre