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Endoglucanases (EGI) (endo-1,4-β-d-glucan-4-glucanohydrolase, EC 3.2.1.4, Cel7B) of Trichoderma reesei are industrially important enzymes. Thus, there is a great need for development of a primary recovery method suitable for large-scale utilization. In this study we present a concept applicable for large-scale purification of an EGI fusion protein by one-step extraction in a poly(ethylene glycol)
Background The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in
Objective: Schizophrenia is associated with premature mortality, but the specific causes and pathways are unclear. The authors used outpatient and inpatient data for a national population to examine the association between schizophrenia and mortality and comorbidities. Method: This was a national cohort study of 6,097,834 Swedish adults, including 8,277 with schizophrenia, followed for 7 years (20
Huntington's disease is a neurodegenerative disorder caused by an abnormal CAG repeat expansion within exon 1 of the huntingtin gene HTT. While several genetic modifiers, distinct from the Huntington's disease locus itself, have been identified as being linked to the clinical expression and progression of Huntington's disease, the exact molecular mechanisms driving its pathogenic cascade and clini
Axonal injury is a hallmark of traumatic brain injury (TBI) and is associated with a poor clinical outcome. Following central nervous system injury, axons regenerate poorly, in part due to the presence of molecules associated with myelin that inhibit axonal outgrowth, including myelin-associated glycoprotein (MAG). The involvement of MAG in neurobehavioral deficits and tissue loss following experi
Solving the mystery of the origin of chondrules is one of the most elusive goals in the field of meteoritics. Recently, the idea of planet(esimal) collisions releasing splashes of lava droplets, long considered out of favor, has been reconsidered as a possible origin of chondrules by several papers. One of the main problems with this idea is the lack of quantitative and simple models that can be u
Introduction: Low aerobic fitness, low muscular strength, and obesity have been associated with premature mortality, but their interactive effects are unknown. This study examined interactions among these common, modifiable factors, to help inform more-effective preventive interventions. Methods: This national cohort study included all 1,547,478 military conscripts in Sweden during 1969-1997 (97%-
Objectives: Increasing incidences of non-typeable Haemophilus influenzae (NTHi) with β-lactam resistance mediated through mutations in penicillin-binding protein 3 (BLNAR or rPBP3) have been observed in the past decades. Recently, an rPBP3 NTHi sequence type (ST) 14 with PBP3 type IIb/A caused a disease outbreak in a nursing home in Sweden with severe outcomes, indicating increased bacterial virul
This paper assesses the potential changes in the demand for forest-based biomass for various energy purposes in Sweden in 2030 and 2050, respectively. The assessment is based on a review of scenarios and predictions of how the Swedish energy system may develop, taking into account techno-economical conditions. It includes potential changes in district heating, electricity production in combined he
Antalet företagsförvärv har de senaste åren ökat och det finns indikationer på att en sådan trend kommer att fortlöpa. En annan trend på marknaden för företagsförvärv är framväxten av AI- teknologin som på olika sätt kan få konsekvenser för förvärvsprocessen. Dessa två trender i kombination med riskfördelningen mellan parterna föranleder uppsatsens syfte som är att utreda köparens undersökningspliThe amount of mergers and acquisitions has during the past years increased and there are factors that speak for such a trend to proceed. Another trend on the market for mergers and acquisitions is the emergence of AI that could contain consequences for the acquisition-process in several ways. These two trends combined with the risk-sharing between the parties give rise to the purpose of the essay
Research shows that aid in many cases is given with a political strategy. Since aid is financed by taxpayers, we find it interesting and relevant to further investigate the political motives behind Swedish aid and if the focus of Swedish aid has differed across time and elected governments. The aim is to empirically investigate the role of the character of the recipient countries and the role of t
Homosexuella par fick möjlighet till juridiskt föräldraskap 2003 som en följd av den statliga utredningen SOU 2001:10 Barn i homosexuella familjer. När ett kvinnligt samkönat par genomgår en insemination inom den svenska offentligt finansierade sjukvården kan föräldraskapet för den kvinna som inte föder barnet fastställas genom dom eller bekräftelse. Om paret genomgår inseminationen i privat regi Homosexual couples in Sweden have had access to legal parenthood since 2003, as a result of SOU 2001:10 Barn i homosexuella relationer (Swedish Government Official Reports series 2001:10 Children in homosexual relationships). When a female same-sex couple undergo insemination at a state-run facility, the parenthood of the woman not carrying the child can be settled through a court judgement or thr
The purpose of this master’s thesis is to provide a contribution to the research body regarding consumer returns, particularly within the online fashion retail industry. A quantitative data analysis approach is chosen and two main methods are used: data study that aims to identify patterns and interesting relationships in the data, and a simulation study that uses real input data to attempt to ide
Background: Blood lead concentrations (B-Pb) were measured in 3 879 Swedish school children during the period 1978-2007. The objective was to study the effect of the proximity to lead sources based on the children's home and school location. Methods: The children's home address and school location were geocoded and their proximity to a lead smelter and major roads was calculated using geographical
Background: Three-dimensional echocardiography (3DE) and semi-automatic right ventricular delineation has been proposed as an appropriate method for right ventricle (RV) evaluation. We aimed to examine how manual correction of semi-automatic delineation influences the accuracy of 3DE for RV volumes and function in a clinical adult setting using cardiac magnetic resonance (CMR) as the reference met
Background: A varying response to cholinesterase inhibitor (ChEI) treatment has been reported among patients with Alzheimer's disease (AD). Whether the individual-specific response, specific ChEI agent or dose affects mortality is unclear. We aimed to examine the relationship between the 6-month response to ChEI and lifespan. Methods: Six hundred and eighty-one deceased patients with a clinical AD
