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BACKGROUND In patients with acute myocardial infarction (MI), therapies that could further reduce the risk of adverse cardiovascular and metabolic outcomes are needed. METHODS In this international registry-based, randomized, double-blind trial, patients without prior diabetes or chronic heart failure, presenting with acute MI and impaired left ventricular systolic function, were randomly assigned

Fungal necromass is increasingly recognized as a major component of soil organic matter, and identifying the factors that govern its formation is critical for understanding and predicting the global carbon cycle. Among these factors, the biochemical composition of mycelial residues at senescence, particularly melanin content, has been consistently identified as a key determinant of the fraction of

Popular Abstract in Swedish Retrovirus är en typ av virus som finns hos både människor och djur. Detta virus sprider sig genom att en virus partikel tar sig in i en cell och sedan integrerar sin virala arvsmassa in i cellens arvmassa, DNA. Retrovirusets arvsmassa är från början RNA men skrivs sedan om till DNA för att kunna integreras. I molekylärbiologins barndom trodde man att det genetiska flödThe human genome contains genetic elements which are more or less similar to infectious retroviruses. These are called human endogenous retroviruses (HERVs) and are thought to be remnants of infections in the primate lineage. Most of them have been inserted 10 to 60 million years ago but have at different time points spread in the genome via intracellular retrotransposition and make up as much as

Industrial biotechnology has been defined as the use and application of biotechnology for the sustainable processing and production of chemicals, materials and fuels. It makes use of biocatalysts such as microbial communities, whole-cell microorganisms or purified enzymes. Although biocatalysts are considered advantageous, since they operate under mild conditions regarding temperature and pH and e

PURPOSE: To compare progressive dynamic, relative quantitative changes in glycans associated with retinal proteins of wild type (wt) and retinal degeneration 1 (rd1) mice during neonatal development and degeneration of retinae. METHODS: Proteins extracted from retinae of postnatal day 2 (PN2), PN7, PN14 wt and rd1 mice were labeled with Cy3-fluorescent dye. Glycome of these proteins was quantified

Ultrasound optical tomography enables noninvasive characterization of tissue and lesions up to 5 cm below the skin surface, by enhancing diffuse optical tomography with ultrasound focusing resolution and an increased number of measurement points. For optimal clinical imaging, it is essential to be able to reconstruct tissue optical properties in real time during in vivo measurements, and therefore

Background: We set out to profile the immune mechanisms active in treatment-naïve oligoarticular JIA (oJIA) to improve the knowledge of its immunopathogenesis, to identify potential biomarkers that can aid diagnosis, predictions and that correlate with clinical disease parameters. Methods: Using Olink proteomics (inflammation panel measuring 92 markers), we defined and compared the inflammation pr

Objective Individuals with SLE commonly report chest pain or discomfort. We performed cardiovascular magnetic resonance (CMR) to differentiate coronary artery disease (CAD), coronary microvascular dysfunction (CMD), pericarditis and myocarditis in individuals with SLE who presented with chest symptoms. We also assessed the clinical utility of CMR. Methods Adults with SLE were included if reporting

Lake water storage variations on the Tibetan Plateau (TP) serve as crucial indicators of regional hydrological dynamics and climate changes, providing more comprehensive insights than discrete measurements of lake area or water level alone. While accurate bathymetric data is fundamental for quantifying lake water storage, conventional bathymetric surveys are often constrained by logistical challen

Background: Blood lead concentrations (B-Pb) were measured in 3 879 Swedish school children during the period 1978-2007. The objective was to study the effect of the proximity to lead sources based on the children's home and school location. Methods: The children's home address and school location were geocoded and their proximity to a lead smelter and major roads was calculated using geographical

Background: Three-dimensional echocardiography (3DE) and semi-automatic right ventricular delineation has been proposed as an appropriate method for right ventricle (RV) evaluation. We aimed to examine how manual correction of semi-automatic delineation influences the accuracy of 3DE for RV volumes and function in a clinical adult setting using cardiac magnetic resonance (CMR) as the reference met

Background: A varying response to cholinesterase inhibitor (ChEI) treatment has been reported among patients with Alzheimer's disease (AD). Whether the individual-specific response, specific ChEI agent or dose affects mortality is unclear. We aimed to examine the relationship between the 6-month response to ChEI and lifespan. Methods: Six hundred and eighty-one deceased patients with a clinical AD

The work presented here is based on two papers, both pertaining to perturbation-based control strategies in industrial fed-batch fermentation processes. The first paper describes a new control strategy for avoiding overflow metabolism in the exponential growth phase of a fermentation, based on analysis of the frequency spectrum of the dissolved oxygen measurement following a periodic perturbation

Background: There are limited prognostic data for locally advanced prostate cancer PCa to guide in the choice of treatment. Objective: To assess mortality in different prognostic categories among men with locally advanced PCa managed with noncurative intent. Design, setting, and participants: We conducted a register-based nationwide cohort study within the Prostate Cancer DataBase Sweden. The enti

Background: Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study was to examine the association of red meat, processed meat, and poultry consumption with the risk of early death in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Background: The need for a mobile workforce inevitably means that the length of the total work day (working and traveling time) will increase, but the health effects of commuting have been surprisingly little studied apart from perceived stress and the benefits of physically active commuting. Methods: We used data from two cross-sectional population-based public health surveys performed in 2004 an