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The groundbreaking field of synthetic biology has immense potential to revolutionize our society by reducing our reliance on petroleum. With a growing demand for sustainable ingredients and molecules, companies like Amyris, who have successfully developed and commercialized this technology, are poised to reap significant rewards. I am privileged to work for a scientifically advanced organization t
By the end of the 1960s there was a growing environmental concern all around the globe. As a part of an answer to this challenge the need was recognized for a reorientation of the education processes towards developing knowledge, attitudes and skills for resolving the issues. This was the birth of the concept of Environmental Education (EE). However, this notion is far from being static as it went
Purpose of study: As both innovations and brand loyalty are becoming ever more important for companies today, it is of importance to understand how an organisation can handle the relationship between the explorative and exploitative units when working with these two constructs. The ultimate aim is to understand how service organisations can be managed in order to enhance brand loyalty through serv
Sustaining crop yields present challenges worldwide. These challenges vary regionally and climate change may have positive or negative effects on crop yields. Closing yield gaps in already established cropping areas is one of the solutions to increase future food supply. Fraction water yield gaps are defined as how far yields with high levels of nutrients are from attainable (irrigated) yields. In
Two approaches for extracting properties of neutral resonances out of invariant mass distributions are presented: like-sign and event-mixing signal. Additionally a correction function based on event-mixing, aimed at revising detection differences of opposite charged particles, which is applied to the like-sign signal is tested. The analysis is conducted using pp collisions at 7 TeV and concludes a
Aerobic granular sludge (AGS) plants have gained growing interest and application due to their low energy demand, small footprint, and low operational costs. However, the fulfilment of strict discharge limits for nitrogen and phosphorus, vast seasonal temperature variations, and large peaks in influent flows may pose challenges to the implementation of AGS. Moreover, the knowledge about microbial
Background: There is growing attention and policy debate about the sharing of personal information that the modernization of electricity grids requires. This is particularly important for big data management in smart grids that needs access to data generated and sent through devices such as smart meters. Using the Nordic Countries as a case study, this study investigates the willingness of people
Tissue and cell examinations have a potential to produce extremely valuable information about antigen quantities in samples. Using currently available methods, a truly quantitative analysis is nearly impossible. We have previously shown that immunohistochemical (IHC) detection of prostate-specific antigen and human glandular kallikrein from prostatic tissue, together with time-resolved fluorescenc
We present the design of the vacuum chamber for the LNLS 2T Hybrid Wiggler. The chamber is a 3m long, 1.2mm thick 316L SS tube, which was mechanically pressed into an elliptical shape from an originally round tube. In order to provide the necessary mechanical tolerances, the rather flexible tube is welded to lateral supports that run the complete length of the chamber. Special care has been given
BACKGROUND: The NextFood Project ( www.nextfood-project.eu) started work in 2018 to identify 'Categories of Skills' that students should be equipped with to address the upcoming global challenges within agrifood and forestry disciplines, and involved concepts such as sustainability, technological adaptation and networking. This study is based on the initial skills and competencies mapping, but tak
Introduction: Rimegepant is an oral small-molecule calcitonin gene-related peptide receptor antagonist approved in several countries for acute treatment of migraine and preventive treatment of episodic migraine in adults. This review summarizes the evidence, published to date, for the use of rimegepant as an acute or preventive treatment of migraine. Areas covered: A brief overview of migraine, th
Introduction: Evidence-based clinical practice guidelines drive optimal patient care and facilitate access to high-quality treatment. Creating guidelines for rare diseases such as haemophilia, where evidence does not often come from randomized controlled trials but from non-randomized and well-designed observational studies and real-world data, is challenging. The methodology used for assessing av
Introduction: The 2024 ISTH clinical practice guideline (CPG) for treatment of congenital haemophilia, the NBDF-McMaster Guideline on Care Models for Haemophilia Management, and ASH ISTH NBDF WFH guidelines on the diagnosis and management of VWD all utilised GRADE methodology. Aim: Discuss missed opportunities and the methodological approach of the ISTH Guideline in contrast to how GRADE was previ
European forests are being shaped by active human use and management, and by harvesting of wood in particular. Yet, our understanding of how forests are harvested across Europe is limited, as the real harvest regimes are not well described by currently available data. Here, we analyse recent harvests, as observed in permanent plots of forest inventories in 11 European countries, totaling to 182,64
We introduce a model description of a diatomic molecule in an optical cavity, with pump and fluorescent fields, and electron and nuclear motion are treated on equal footing and exactly. The model accounts for several optical response temporal scenarios: A Mollow spectrum hindered by electron correlations, a competition of harmonic generation and molecular dissociation, a dependence of fluorescence
Background: People with Parkinson’s disease has significant and increasing physical, psychosocial and spiritual needs, as well as problems with coordination and continuity of care. Despite the benefits that palliative care could offer, there is no consensus on how it should be delivered. Aim: The aim of this study is to provide a pragmatic overview of the evidence to make clinical recommendations
Polyphenols are a group of compounds that are widely spread in the plant kingdom. These compounds are of great interest for researchers because of their antioxidant properties that are important for both plant life and human health. Sample preparation is a crucial step for the determination of phenolic compounds and their metabolites in biological samples. Methods for isolation and preconcentratio
IntroductionEmerging evidence suggests a difference in access to facilities for medical termination of pregnancy (MTP) and delivery among women in different regions of the country. However, we lack assessments at a large scale across all geographies. Our study aims to describe the percent contribution of private and public sectors in institutional deliveries and MTP in India.MethodsA secondary dat
Aggregation of α-synuclein is associated with neurodegeneration and a hallmark pathology in synucleinopathies. These aggregates are thought to function as prion-like particles where the conformation of misfolded α-synuclein determines the traits of the induced pathology, similar to prion diseases. Still, little is known about the molecular targets facilitating the conformation-specific biological
