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Advanced cancer, with its considerable physical symptoms and psychosocial burdens, represents an existential threat and major stressor to patients and their caregivers. In response to such stress, patients and their caregivers use a variety of strategies to manage the disease and related symptoms, such as problem-focused, emotion-focused, meaning-focused, and spiritual/religious coping. The use of
Quality control of stabilized dredged sediment (DS) presents significant challenges due to its high-water content. Nowadays, many in-situ and laboratory tests have been used to evaluate the quality of treated DS, and the dominant method is 28-day unconfined compressive strength that can be done on undisturbed samples from the field and the laboratory. Due to the waiting period to get results from
Changes in biomarker levels of Alzheimer’s disease (AD) reflect underlying pathophysiological changes in the brain and can provide evidence of direct and downstream treatment effects linked to disease modification. Recent results from clinical trials of anti–amyloid β (Aβ) treatments have raised the question of how to best characterize the relationship between AD biomarkers and clinical endpoints.
Multi-functional molecules with spirocyclic acetal structures have recently emerged as attractive monomers to prepare high-performance polymers, which may subsequently be de-polymerized and recycled under specific physicochemical conditions. Spirocyclic acetal structures can be formed by condensation of a suitable aldehyde or ketone with a polyol so that the functionalities necessary for the polym
Since the last edition of this book (2014), progress has been astonishing in all areas of Natural Language Processing, with recent achievements in Text Generation that spurred a media interest going beyond the traditional academic circles. Text Processing has meanwhile become a mainstream industrial tool that is used, to various extents, by countless companies. As such, a revision of this book was
Purpose: Prior research has proposed a number of scales measuring the customer experience (CX), which tend to conceptualize and operationalize CX differently, raising potential confusion among researchers (e.g. regarding which scale to use). Addressing this issue, this article conducts a systematic review to inventorize key CX scales and assess their theoretical rigor, with a focus on the identifi
Objectives: To perform a descriptive analysis of a series of patients with recurrent macroscopic haematuria after a primary standard evaluation including computed tomography urography (CTU) and cystoscopy negative for urinary bladder cancer (UBC) and upper tract urothelial cancer (UTUC) and to identify potential factors associated with occurrence of recurrent macroscopic haematuria. Methods: All p
Climate change has diverse effects on the planet’s environment, including changes and shifts in the distribution and abundance of species. In this paper, we present a robust prediction ensemble algorithm for the current and future species distribution of Aegilops tauschii. Four modeling approaches were trained using various environmental variables (bioclimatic and soil variables) to accurately pre
Protein tyrosine phosphatases (PTPs) possess a conserved mobile catalytic loop, the WPD-loop, which brings an aspartic acid into the active site where it acts as an acid/base catalyst. Prior experimental and computational studies, focused on the human enzyme PTP1B and the PTP from Yersinia pestis, YopH, suggested that loop conformational dynamics are important in regulating both catalysis and evol
We aimed to explore social workers’ experiential accounts of developing complex interventions for youth and families within practice settings. Social workers’ experience of developing interventions has not been leveraged in scientific research even though many complex interventions in use are developed by social workers in practice settings. Lack of insight into the intervention development proces
The Epithelial Science Expert Group convened on 18–19 October 2023, in Naples, Italy, to discuss the current understanding of the fundamental role of the airway epithelium in asthma and other respiratory diseases and to explore the future direction of patient care. This review summarises the key concepts and research questions that were raised. As an introduction to the epithelial era of research,
Food packaging is one of the most important strategies to prevent food damage or spoilage during storage and the supply chain. Among various food types, seafood, a high-value product, is particularly vulnerable to post-harvest quality loss and microbial contamination during storage. Although current plastic-based packaging materials are durable, they pose a serious threat to the environment. There
Modern hydrological modeling frequently incorporates global remote sensing or reanalysis products for multivariate calibration. Although these datasets significantly contribute to model accuracy, the inherent uncertainties in the datasets and multivariate calibration present challenges in the modeling process. To address this issue, this study introduces an adaptive, process-wise fitting framework
BACKGROUND: While the associations between pediatric non-obese metabolic dysfunction-associated fatty liver disease (MAFLD) and multiple diagnostic biomarkers are well-established, the role of a broader range of blood-based, urine-based, and body composition-based biomarkers for monitoring MAFLD are needed.METHODS: A pediatric cohort was established in Wuxi, China. We measured body composition bio
We explore how the Resilient Urban Food Systems (RUFS) project applied a theory of change approach to raise awareness of the importance of smallholder farmers and to bring them into decision making processes, as key players working towards a sustainable and resilient food system in Kasese Municipality and Mbale City in Uganda. Critical inputs from using a theory of change approach included: consta
The serine protease cathepsin G is synthesized during the promyelomonocytic stage of neutrophil and monocyte differentiation. After processing, including removal of an amino-terminal propeptide from the catalytically inactive proform, the active protease acquires a mature conformation and is stored in azurophil granules. To investigate the importance of the proform-conformation for targeting to gr
Failure mode and effects analysis (FMEA) is a critical but labor-intensive process in product development that aims to identify and mitigate potential failure modes to ensure product quality and reliability. In this paper, a novel framework to improve the FMEA process by integrating generative artificial intelligence (AI), in particular large language models (LLMs), is presented. By using these ad
Background: Recurrent coarctation of the aorta (re-CoA) is a well-known although not fully understood complication after surgical repair, typically occurring in 10%–20% of cases within months after discharge. Objectives: To (1) characterize geometry of the aortic arch and blood flow from pre-discharge magnetic resonance imaging (MRI) in neonates after CoA repair; and (2) compare these measures bet
