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OBJECTIVE: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are chronic, relapsing inflammatory diseases, yet reliable biomarkers for detecting relapse and organ involvement remain limited. This study aimed to identify plasma protein biomarkers that distinguish active disease from remission and to explore markers associated with lung and kidney involvement.METHODS: Plasma
Background: Data are lacking on left ventricular ejection fraction (LVEF) trajectory following myocardial infarction (MI). Objectives: This study aimed to evaluate the impact of LVEF trajectory after percutaneous coronary intervention (PCI) for MI on long-term outcomes. Methods: Patients undergoing PCI for MI (2007-2022) with serial echocardiograms were identified in the Swedish Coronary Angiograp
The continuum mechanics fatigue model operates on state variables that are continuous in time, unlike cycle-counting-based methods that rely on deconstructing stress histories into a set of distinct cycles. This way, the continuum-based approach provides a modeling framework that, in principle, can handle arbitrary stress histories. Despite its successful application for a wide range of problems,
Language-based assessments (LBAs), quantitative estimates of scientific constructs based on language, have advanced methods in the psychological and social sciences for more than a decade. LBAs based on individuals’ prompted descriptions analyzed with large language models to produce scores of their psychological states and traits have shown strong convergence with the corresponding rating scales
We explore how the Resilient Urban Food Systems (RUFS) project applied a theory of change approach to raise awareness of the importance of smallholder farmers and to bring them into decision making processes, as key players working towards a sustainable and resilient food system in Kasese Municipality and Mbale City in Uganda. Critical inputs from using a theory of change approach included: consta
The serine protease cathepsin G is synthesized during the promyelomonocytic stage of neutrophil and monocyte differentiation. After processing, including removal of an amino-terminal propeptide from the catalytically inactive proform, the active protease acquires a mature conformation and is stored in azurophil granules. To investigate the importance of the proform-conformation for targeting to gr
Failure mode and effects analysis (FMEA) is a critical but labor-intensive process in product development that aims to identify and mitigate potential failure modes to ensure product quality and reliability. In this paper, a novel framework to improve the FMEA process by integrating generative artificial intelligence (AI), in particular large language models (LLMs), is presented. By using these ad
Background: Recurrent coarctation of the aorta (re-CoA) is a well-known although not fully understood complication after surgical repair, typically occurring in 10%–20% of cases within months after discharge. Objectives: To (1) characterize geometry of the aortic arch and blood flow from pre-discharge magnetic resonance imaging (MRI) in neonates after CoA repair; and (2) compare these measures bet
One of the main challenges as the market for fully commercial electrified vehicles quickly expands is predicting the electromagnetic interference (EMI) in traction voltage systems (TVSs) in differential mode (DM) and common mode (CM). The number of subsystems connected to vehicle TVSs is increasing, and thus, so are the electromagnetic compatibility (EMC) requirements. These requirements should ma
AI cancer detection models require calibration to attain the desired balance between cancer detection rate (CDR) and false positive rate. In this study, we simulate the impact of six types of mismatches between the calibration population and the clinical target population, by creating purposefully non-representative datasets to calibrate AI for clinical settings. Mismatching the acquisition year b
In this paper we show that OpenAI’s Large Language Model (LLM) GPT perform remarkably well when used for title and abstract eligibility screening of scientific articles and within a (systematic) literature review workflow. We evaluated GPT on screening data from a systematic review study on electric vehicle charging infrastructure demand with almost 12,000 records using the same eligibility criter
Naturvetenskap, teknik, ingenjörsvetenskap och matematik, på engelska ofta grupperade under akronymen STEM, är traditionellt mansdominerade områden. Särskilt inom ingenjörsvetenskap och teknologi är kvinnor fortfarande kraftigt underrepresenterade. Bristen på kvinnor inom STEM innebär utmaningar i att möta arbetsmarknadens behov, för produktkvalitet på grund av brist på olika perspektiv i designprScience, technology, engineering and mathematics, often grouped under the acronym STEM, are traditionally male dominated fields. Especially in engineering and technology, women continue to be heavily underrepresented. The lack of women in STEM poses challenges for meeting the labor market demands, for product quality due to a lack of diverse perspectives in the design process, and for gender equal
How we teach is strongly influenced by the culture we teach in, especially what (we believe) our colleagues think is good and acceptable. Understanding the reluctance to changes in teaching practice, including fear of disapproval from colleagues and students, investigating and reappraising those fears, and starting to talk about alternative interpretations is a first step towards overcoming the in
A novel concept of cold neutron source employing chessboard or staircase assemblies of high-aspect-ratio rectangular para-hydrogen moderators with well-developed and practically fully illuminated surfaces of the individual moderators is proposed. An analytic approach for calculating the brightness of para-hydrogen moderators is introduced. Because the brightness gain originates from a near-surface
The use of gender-inclusive pronouns aims to make language more inclusive and to reduce biases and prejudices based on gender. Previous research shows that men tend to resist gender-inclusive pronouns more strongly than other individuals. The aim of the current study is to contribute to the understanding of this stronger resistance among men. We hypothesize that men are more negative toward gender
Recent studies provide insights about local agency in regional development. While acknowledging non-local actors and drivers, these studies have not systematically discussed the link between extra-regional relations and local agency. This paper first discusses three key arguments in the literature on extra-regional relations covering context-specific dependencies, strategic coupling and open innov
Separating how surface and subsurface species affect catalytic function is a challenging task in heterogeneous catalysis, particularly when deposition and segregation take place at reaction conditions. Here, we report on an operando approach to establish surface/subsurface/function correlations. Using temperature modulations we oscillate carbon deposition and segregation over a Pd catalyst. Cataly
