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Context: Rapid growth has been suggested to promote islet autoimmunity and progression to type 1 diabetes (T1D). Childhood growth has not been analyzed separately from the infant growth period in most previous studies, but it may have distinct features due to differences between the stages of development. Objective: We aimed to analyze the association of childhood growth with development of islet
Global policies, legislation, and eco-friendly initiatives have induced the steel industry to integrate sustainable development approaches. Sustainability requires all phases from raw material sourcing to transportation to waste and carbon footprint elimination—yielding positive effects. This research employs a two-step approach in sustainability. The first phase entails conducting a systematic li
The delay between the origin of animals in the Neoproterozoic and their Cambrian diversification remains perplexing. Animal diversification mirrors an expansion in marine shelf area under a greenhouse climate, though the extent to which these environmental conditions directly influenced physiology and early organismal ecology remains unclear. Here, we use a biogeochemical model to quantify oxygen
Background Suicide attempts are common in youth and have potentially lethal outcomes. Effective treatments targeting suicide attempts are scarce. Objective To assess the feasibility and preliminary efficacy of a family-based cognitive behavioural treatment relative to an active control for youth with suicidal behaviour. Methods 30 youths (93% female; mean (SD) age=14.6 (1.5) years) residing in Swe
Abstract Herein we report on the decarboxylative alkenylation between alkyl carboxylic acids and enol triflates. The reaction is mediated by a dual catalytic nickel and iridium system, operating under visible light irradiation. Two competing catalytic pathways, from the excited state iridium photocatalyst, are identified. One is energy transfer from the excited state, resulting in formation of an
Key questions for understanding hippocampal function in memory and navigation in humans are the type and source of visual information that reaches the human hippocampus. We measured bidirectional pairwise effective connectivity with functional magnetic resonance imaging between 360 cortical regions while 956 Human Connectome Project participants viewed scenes, faces, tools, or body parts. We devel
Despite the crucial role of various insulin analogs in achieving satisfactory glycemic control, a comprehensive understanding of their in-solution dynamic mechanisms still holds the potential to further optimize rapid insulin analogs, thus significantly improving the well-being of individuals with Type 1 Diabetes. Here, we employed hydrogen-deuterium exchange mass spectrometry to decipher the mole
Using a microcontroller unit to implement different machine learning algorithms for myoelectric prosthesis control is currently feasible. Still there are hardware and timing constraints that need to be accounted for. This master thesis presents results from automatically generated Arduino code for some Neural Networks, Convolution Neural Networks and linear machine learning models that was impleme
Kunskap om markens uppbyggnad är viktig både för konstruktions och prospekteringsändamål. Geofysiska undersökningsmetoder kan användas för att skapa en överblick att basera vidare undersökningar på. I den här studien används likströms resistivitet och inducerad polarisation, IP. Datan är inverterad med en Cole-Cole modell i programmet ÅrhusInv och använd för att karakterisera berggrunden vid ÖnnesFor both construction and exploration purposes, knowledge of the subsurface is important. Geophysical exploration methods can be used to acquire an overview of an area on which further investigations can be based. In this study direct current resistivity and induced polarization data, inverted with a Cole-Cole model in program AarhusInv, are used to characterize the bedrock at Önneslöv in Scania,
The purpose of this thesis is to determine how electric vehicle trucks can meet the needs of customers in the urban building and construction sector. This sector contributes significantly to greenhouse gas (GHG) emissions, and also creates noise and other disturbances in urban environments. There are multiple benefits that come with electric trucks, which can address these issues if they are used
Förenta Nationernas fredsbevarande operationer har under nästan två decennier besvärats av anklagelser om sexuellt utnyttjande av och sexuella övergrepp på civilbefolkningar. Flera rapporter visar inte bara att organisationens fredsbevarande styrkor begår dessa brott mot just de människor de fått i uppdrag att beskydda, utan också att de undgår ansvar och straff. Denna uppsats undersöker och utvärUnited Nations peacekeeping operations have, for the better part of two decades, been plagued by allegations of sexual exploitation and abuse of local civilian populations. Several reports indicate not only that peacekeepers exploit and abuse the very people they were sent to protect, but also that these crimes routinely go unpunished. This thesis examines and evaluates the different methods of ho
Due to the focus of their study program, environmental and sustainability students are vulnerable to experience negative emotional impacts, potentially affecting their mental health. This thesis contributes to increased understanding of emotions and emotional resilience in relation to the climate crisis by examining experienced emotions, studying the power students have over their emotions, and po
As the need to adapt to a changing climate and the political rhetoric in this regard are growing, Berlin’s Senate has issued strategic policies – complemented by an increase of funding. Berlin’s socio-cultural features and place-based factors seem predisposed for so-called “Nature-based Solutions” (NbS) that can support the achievement of adaptation efforts. This encouraging context seems to be co
Climate change is the greatest challenge of our time. Despite efforts to reduce greenhouse gas (GHG), the emissions contribution from global aviation is set to increase. Electric aviation has emerged as an alternative which could form part of the solution. Sweden, which is on the path to carbon neutrality and has a long history in aviation, could contribute to the global efforts in mitigating clim
Smart City is a paradigm for the development of urban spaces through the implementation of state-of-the-art ICT. There are two main approaches when developing Smart Cities: top-down and bottom-up. Based on the bottom-up approach, the concepts of Smart People and Smart Communities have emerged as dimensions of the Smart City, advocating for the engagement of citizens in Smart People initiatives. Th
Randomized, double-blind, controlled studies have shown that treatment with risedronate reduces the risk of vertebral fracture in postmenopausal women with established vertebral osteoporosis. They also show that the drug decreases the risk of non-vertebral fractures in women with osteoporosis. The aim of this study was to investigate the cost-effectiveness of risedronate in postmenopausal women wi
In this study, we examined the onset and duration of local analgesic effects of bupivacaine incorporated into biodegradable microcapsules (extended-duration local anesthetic; EDLA) administered as subcutaneous infiltrations in different doses in humans. In 18 volunteers, the skin on the medial calf was infiltrated with 10 mL of EDLA, and the opposite calf was infiltrated with 10 mL of aqueous bupi
