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Background: Joint pain and chronic back pain are highly prevalent in the aging population and have a large impact on life quality. As the underlying mechanisms are not fully understood, this exploratory cross-sectional study aimed to discover proteins and pathways associated with these two pain conditions in Swedish 70-year-old men. Methods: Plasma proteins (n = 720) were measured in participants
This paper explores an initiative by a local government in Rättvik, Sweden, to increase the consumption of local food in the municipal kitchens. It explores public procurement of local food as a way for local governments to address sustainability and climate goals while meeting residents’ demand for ‘good’ local food. Through a qualitative case study reviewing food and procurement policies across
Introduction.Kraft black liquor is a side-stream produced during the kraft pulping process containing lignin, hemicelluloses and cooking chemicals. The stream is usually evaporated and burned in the recovery boiler to recover the cooking chemicals and generate energy. The mill is, however, often/sometimes limited by recovery boiler capacity, and removing some of the lignin from kraft black liquor
Researchers have widely applied discharge simulation using artificial neural networks (ANNs) and have gained prominence in water resources. Morphological features, watershed urbanization, and climate change influence hydrological variables. Thus, data-driven models need to be able to identify the hydrological relationships without explicitly stating the physical processes. The main objectives of t
Creating software tools that address the needs of a wide range of decision-makers requires the inclusion of differing perspectives throughout the development process. Software tools for biodiversity conservation often fall short in this regard, partly because broad decision-maker needs may exceed the toolkits of single research groups or even institutions. We show that participatory, collaborative
The use of CRISPR-Cas bacterial adaptive immunity system components for targeted DNA changes has opened broad prospects for programmable genome editing of higher organisms. The most widely used gene editors are based on the Cas9 effectors of the type II CRISPR-Cas systems. In complex with guide RNAs, Cas9 proteins are able to directionally introduce double-stranded breaks into DNA regions that are
Starting with the lead compound roquinimex, a selection of 3-quinolinecarboxamide derivatives were synthesized and evaluated for the treatment of the autoimmune disease multiple sclerosis. Structure-activity relationships were established in animal studies and from these, laquinimod was chosen as the drug candidate due to its superior potency and toxicological profile as compared to roquinimex. Ho
Single-cell technologies have transformed our understanding of cellular heterogeneity through multimodal data acquisition. However, robust cell alignment remains a major challenge for data integration and harmonization, including batch correction, label transfer, and multi-omics integration. Many existing methods constrain alignment based on rigid feature-wise distance metrics, limiting their abil
DNA replication relies on precise coordination between proteins, including the sliding clamp proliferating cell nuclear antigen (PCNA), which encircles DNA to interact with key players in replication and repair. While biochemical studies have demonstrated interactions between PCNA and DNA polymerases δ and ε during DNA synthesis, the functional role of the Pol ε–PCNA interaction in vivo, particula
The testing and safety cases of assisted and automated driving (AAD) functions require considerations for nonideal environmental conditions, such as adverse and extreme weather. In these extreme conditions, perception sensors (e.g., camera, LiDAR, and RADAR), which build the situational awareness of the vehicle, might produce noisy and degraded data. Therefore, it is key to consider: 1) how to rel
With the increasing prevalence of microplastics (MPs) and nanoplastics (NPs) in global aquatic environments, their potential ecotoxicological and health impacts have become a major concern in environmental science. Slow sand filtration (SSF) is widely recognized for its low energy demand, ecological compatibility, and operational stability; however, its efficiency in removing small or neutrally bu
The operation of instruments and detectors in laboratory or beamline environments presents a complex challenge, requiring stable operation of multiple concurrent devices, often controlled by separate hardware and software solutions. These environments frequently undergo modifications, such as the inclusion of different auxiliary devices depending on the experiment or facility, adding further compl
Reliable and cost-effective operation of structural systems over their service life depends on the implementation of Structural Health Monitoring (SHM) and maintenance activities, which influence operational costs, the expected costs of failure and downtime. Decision Value Analysis (DVA) provides a framework to quantify the value of such activities by evaluating their effect on total expected life
Effective medical education relies on clearly defined learning objectives that foster deep and meaningful learning. This article presents a consensus-driven proposal for national learning objectives in dermatology and venereology within Sweden’s new medical programme qualifying for licensure. The primary aim is to harmonize educational standards across all medical faculties and to establish a comm
IntroductionSport-related concussion (SRC) is a pressing issue in Para sport, yet biomechanical mechanisms remain poorly understood. Athletes with visual impairment face elevated risks due to sport-specific demands, such as frequent collisions in blind football. This pilot study examined head acceleration responses in blind football players compared with non-disabled football players, and between
IntroductionSport-related concussion (SRC) is a major health concern in contact sports. Linear head acceleration (LHA) and rotational head acceleration (RHA) are central biomechanical markers, and anticipatory neck muscle activation may mitigate these forces. Evidence on how anticipation influences head kinematics, and whether sex differences exist, remains limited. This study compared head accele
Take Home Message Using Germany as a case example, a comparison between organized mammography screening and contemporary, risk-adapted screening for prostate cancer suggests that prostate-specific antigen–based early detection with incorporation of magnetic resonance imaging and active surveillance can achieve benefits comparable to those of mammography while addressing previous concerns about ove
