Filtyp
ObjectivesThis study investigates the impact of transitioning from restricted to 24/7 access to blood culture cabinets on blood culture processing.MethodA post-hoc retrospective study and a prospective laboratory simulation to evaluate the effects of delayed incubation were conducted. Data analysis evaluated clinical data comparing incubation-to-detection (ITD) and Collection-to-detection (CTD) in
Background: Hearing loss is estimated to affect more than 20% of the global population. Hearing aid fitting is a common intervention in audiological rehabilitation; however, there are still those who struggle with remaining communication difficulties that require additional intervention. The group rehabilitation program Active Communication Education (ACE) has been shown to be an effective alterna
BACKGROUND: The period immediately following psychiatric inpatient care is recognized as a time of elevated risk of suicide, yet little is known about factors that influence how soon suicide occurs after discharge.AIM: To examine the timing of suicide among persons after psychiatric discharge and identify sociodemographic and clinical factors associated with a shorter time to death by suicide.METH
We assessed hepatocellular carcinoma (HCC) risk associated with smoking and alcohol consumption and their interactions, using both questionnaire data and objective serum biomarkers. Information on smoking and alcohol consumption was collected at baseline from 450,112 participants of the EPIC cohort, among whom 255 developed HCC after a median follow-up of 14 years. In a nested case–control subset
BACKGROUND: Accurate risk stratification in older adults presenting to the emergency department (ED) is essential but challenging due to atypical presentations and age-related physiological changes. While vital signs are central to triage, their predictive value for short-term mortality in this population remains unclear. This study aimed to explore the association between initial vital signs and
Background: Opioid use disorder is a chronic disorder with a high risk of overdose-related morbidity and mortality where a large proportion of these can be averted by timely administration of the antidote naloxone. For naloxone to be present when and where overdoses occur, broad-scale overdose education and naloxone distribution (OEND) must be established. A regional naloxone program was implement
BACKGROUND: Prior research has established a positive association between the single-measured triglyceride-glucose (TyG) index and hypertension. Nevertheless, longitudinal studies addressing the enduring impact of TyG index on incident hypertension are lacking. This study sought to explore the association between cumulative TyG index (cum-TyG) and incident hypertension, especially obesity-related
Background: Selected patients with advanced germ cell tumors have a poor prognosis. These include patients with brain, bone or liver metastases, very elevated tumor markers or primary mediastinal tumor. High-dose chemotherapy (HDCT) with autologous stem cell support is recommended in the Swedish and Norwegian Testicular Cancer Group (SWENOTECA) guidelines in selected poor risk patients with poor r
BACKGROUND: Preoperative anaemia is associated with increased use of blood transfusions, a greater risk of postoperative complications, and patient morbidity. The IRON NOF trial aimed to investigate whether the administration of i.v. iron in anaemic patients during hip fracture surgery reduced the need for blood transfusion and improved patient outcomes.METHODS: This phase III double-blind, random
Antibiotic resistance poses a global threat. Antibiotics are administered to 80-90% of terminally ill patients but evidence of their effectiveness in improving survival or symptom relief at the end of life (EOL) is scarce. To determine the proportion of deceased patients that continue antibiotic treatment after documented EOL discussion and the decision to prioritise symptom relief over active tre
BackgroundImmune-related hepatitis (ir-hepatitis) ranks among the most frequent adverse events of immune checkpoint inhibitors (ICIs). Limited knowledge exists regarding the incidence, characteristics, and treatment of patients having an inadequate response to initial therapy with steroids. Characterizing ir-hepatitis phenotypes and treatment responses can provide valuable insights for guiding tre
Background: The global plant-based food shift puts high pressure on manufacturing capacity at facilities like Oatly's Landskrona site. This environment faces high combinatorial complexity due to growing product variety and sequence-dependent cleaning requirements. Relying on manual, experience-based planning to navigate these rules limits throughput and introduces organisational risk. Purpose
Childhood cancer aetiology is poorly understood and is considered to originate in utero and early postnatal life. In this study, we investigated perinatal characteristics as potential risk factors by performing a population-based case-control study, including 1340 cancer cases diagnosed < 19y and born between 1989–2021 in southern Sweden, and 13400 controls matched by sex, year, and municipality o
Biodiversity hotspots are biogeographic regions exceptionally rich in endemic species showing high rates of habitat loss, making them the priority of global conservation efforts. As part of the biodiversity hotspot with the highest density of endemic species, the West Usambara Mountains in Tanzania require an efficient and resourceful monitoring solution. This thesis aimed to model the tree specie
Forest Aboveground biomass (AGB) is an important indicator of forest carbon storage, but long-term, high-resolution, and spatially continuous Aboveground biomass estimation remains challenging. This study produced annual forest Aboveground biomass estimates across mainland Spain and the Balearic Islands from 2000 to 2024 at 30 m resolution by combining Landsat time series, Global Ecosystem Dynamic
Objective. Increasing survival of extremely low birth weight (ELBW; birth weight < 1000 g) infants raises a concern regarding the risks of adverse long-term outcome such as cognitive dysfunction. Few studies have reported long-term follow-up of representative regional cohorts. The objective of this study was to assess the 5-year outcome of a prospectively followed national ELBW infant cohort. Meth
Patients with acute asthma attending the emergency room were included in a double-blind, double-dummy and parallel group study to investigate whether a dry powder inhaler (Turbuhaler) can be used in acute asthma. If so, the aim was to establish the potency relationship between a beta 2-agonist (salbutamol) administered by the dry powder inhaler and the pressurized metered-dose inhaler (pMDI). Eigh
Objective: We used dual X-ray absorptiometry (DXA) to measure calcaneal bone mineral density (BMD) and estimate the prevalence of osteoporosis in a population with distal forearm fracture and a normative cohort. Methods: Patients 20 to 80 years of age with distal forearm fracture treated at one emergency hospital during two consecutive years were invited to calcaneal BMD measurement; 270 women (81
Popular Abstract in Swedish Esofagektomi (kirurgiskt avlägsnande av matstrupen) är ett omfattande ingrepp som främst utförs pga cancer, men som även utförs vid vissa godartade sjukdomar. Matstrupen sträcker sig från svalget, via bakre delen av bröstkorgen ned till övre delen av buken. Det anatomiska läget gör att man ur kirurgisk synpunkt oftast måste avlägsna matstrupen via en kombination av inciIn a prospective randomised study following oesophagectomy and gastric tube reconstruction patients with hand-sutured neck anastomoses were compared with patients with circular stapled chest anastomoses. The two groups had equal rates of anastomotic or conduit leaks of 7.3 % (3/41) and 7.1 % (3/42) and of benign anastomotic strictures of 19.5 % (8/41) and 28.6 % (12/42). Another prospective random
Popular Abstract in Swedish Under det senaste decenniet har risker med och alternativ till allogent blod (blod från främmande givare) debatterats mycket pga. risken för smitta, allergiska reaktioner, samt starka indicier som talar för att blod från främmande givare kan påverka immunförsvaret hos mottagaren. Därför vill man gärna begränsa mängden tillfört givarblod under kirurgiska ingrepp på barn,In children, it is often desirable to minimize allogenic blood transfusion, and this thesis explores the physiology of an alternative method of managing perioperative blood loss: hemodilution with Ringer´s dextran. Methods Clinical studies: Arterial pressure, superior caval venous oxygen saturation (ScvO2) and blood lactate concentration (L) were studied during bone marrow harvesting (BMH) on 23
