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Multiplex proteomic platforms provide excellent tools for investigating associations between multiple proteins and disease (e.g., diabetes) with possible prognostic, diagnostic, and therapeutic implications. In this study our aim was to explore novel pathophysiological pathways by examining 92 proteins and their association with incident diabetes in a population-based cohort (146 cases of diabetes
This thesis addresses the corporate sustainability process and different tools to assist the process of generating corporate strategies towards sustainability in the energy sector. The focus of the research was in backcasting approaches. The main outcome of the work is a framework for corporate sustainability for the energy sector. The framework is constructed around a three step strategic plannin
Elements of the Ordovician conodont genus Protopanderodus have been investigated in order to provide a model of reconstruction for its oral apparatus. In total, 4202 elements from the five named species representing this genus in the Swedish Middle Ordovician are included in this study; P. rectus, P. parvibasis, P. graeai, P. robustus, and P. calceatus. The well-preserved specimens were studied in
A power-series expansion method for rigorous analysis of the guided modes in a cylindrical, radially inhomogeneous, dielectric waveguide is presented. The method is developed for an arbitrary piece-wise polynomial permittivity profile. The field solutions of the inhomogeneous core are constructed by a sequence of power-series expansions. Convergence is ensured and accuracy maintained by regulating
Segmental defects of long bones are notoriously difficult to treat. This study evaluates eight cases in which the Masquelet technique of induced membranes was used. The primary purpose was to assess the results compared to other types of bone reconstruction and share our tips and tricks to improve the outcome.
A prototype to a water-cooled applicator to be used in transurethral laser-induced thermotherapy of benign prostatic hyperplasia was developed. The flexible applicator was made of Teflon(TM) tubes except for the distal outer part which was made of glass, providing a transparent medium for laser radiation and enabling efficient cooling of the surrounding tissue. For heating, laser light from a Nd:Y
Objectives. BMD in the hand, as evaluated by digital X-ray radiogrammetry (DXR), has been suggested to be a predictor for joint damage in RA. A predictor for long-term prognosis might also predict increased mortality in RA. The aim of the present study was to evaluate BMD in the hand as a predictor for all-cause mortality. Methods. In 1978, 152 consecutive patients (78% women, mean disease duratio
Popular Abstract in Swedish Ta ett djupt andetag och tänk på vad du nu har i lungorna! Jo, det är luft, förstås, syre kväve och sådant. Men det är också något annat. I varje kubikcentimeter du andas in finns tusentals partiklar, alla för små för att kunna ses med blotta ögat. Om dessa partiklar handlar denna avhandling. Vi kallar luftburna partiklar för aerosoler, ett begrepp som innefattar allt Airborne particles are everywhere around us, and have always been. Particles generated by human activities has increased drastically since industrialization, and several epidemiological studies have shown that inhaled particles can cause adverse health effects. The concern about health effects have during the last decade shifted towards fine and ultrafine particles, not least due to the emerging f
The function of the immune system requires coordinated expression and action of many genes and proteins. With the emergence of high throughput technologies it has become possible to target human immunity from a systems biology point of view. To perform systems biology studies with comparable results we need not just a reference gene and protein set but also useful and descriptive reference categor
BACKGROUND: Sarcoidosis has been reported to be associated with an increased risk of cancer; however, little information is available about the prognosis for sarcoidosis patients diagnosed with cancer. PATIENTS AND METHODS: A population-based cohort of sarcoidosis patients was identified from Swedish registers. Cause-specific and overall hazard ratios (HRs) were estimated by using Cox regression m
The incidence of deep infection using a synthetic mesh in inguinal hernia repair is low and reported to be well below 1%. This is in contrast to incisional hernia surgery where the reported incidence is 3% respective 13% comparing laparoscopic to open mesh repair reported in a Cochrane review. Main risk factors were long operation time, surgical site contamination, and early wound complications. A
Using two-pulse photon echo excitation a strong resonance in the measured homogeneous dephasing time as a function of magnetic field is observed in the H-3(4)-D-1(2) transition of Pr3+:YAlO3. The resonance could only be observed at low excitation energies since it otherwise was masked by excitation intensity dependent extra dephasing processes in the crystal. Thus intensity dependent dephasing pro
Since the introduction of unilateral parathyroidectomy for primary hyperparathyroidism (pHPT) it has been debated wherever this approach is associated with greater long-term risk for recurrence compared to bilateral neck exploration.
AIMS: The sural nerve is the commonest peripheral nerve biopsied to help in the diagnosis of peripheral neuropathy of unknown cause. However, associated complications limit its use. The aim was, as an alternative, to asses biopsy of the terminal branch of the posterior interosseous nerve (PIN) in the forearm. METHODS: PIN pathology was morphometrically quantified in 10 male patients with Type 2 di
ABSTRACT: BACKGROUND: It is known that physical activity during growth has a positive influence on bone mineral accrual, and is thus possibly one strategy to prevent osteoporosis. However, as bone geometry, independent of areal bone mineral density (aBMD), influences fracture risk, this study aimed to evaluate whether hip structure in pre-pubertal girls is also affected by a two-year exercise inte
BACKGROUND: Each year, more than 1.5 million people in Europe have a stroke, and many experience disabilities leading to activity and participation restrictions. Home-based rehabilitation is the recommended approach for stroke rehabilitation, in line with the international shift to integrated care. Despite this, rehabilitation often focuses on the person's physical functions, not the whole life si
Background: Young adults with autism often have problems with body awareness, also acknowledged by physiotherapists. This may interfere with various physiological and psychological responses, expressed in reduced movement quality. Basic Body Awareness Therapy (BBAT) may be suitable to address these difficulties, to enhance body awareness and movement quality to manage everyday life. Body Awareness
The European Environmental Research Infrastructures (ENVRI) community, in its pursuit of enabling seamless and FAIR (Findable, Accessible, Interoperable, and Reusable) access to environmental research data and services, has realised the ENVRI Catalogue of Services. This paper provides an in-depth look into the creation of this tool, highlighting the process, the challenges faced, and the scientifi
