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Participants in an international conference on the management of haemophilia patients with inhibitors developed a jointly authored summary of the findings and conclusions of the conference. Current knowledge of the genetic and immunologic mechanisms underlying inhibitor development was briefly summarized. Concerning the purported treatment-related risk factors, conference participants commented on
Almost all Swedish politicans since 1960 honestly believe in the necessity to give pupils real influence over their schools. The first aim with this paper is to give them some sound theoretical support for their conviction that experience of democratic processes is one important precondition for the survival of democracy. The theoretical support is drawn from researchers inspired by Piaget's epist
Several different factors may determine where species range limits are located within regions of otherwise continuously available habitat and suitable climate. Within the Arctic tundra biome many bird species are migratory and their breeding distributions are affected by migration routes that are in turn limited by factors such as suitable winter habitat, migratory stopover sites, geographical bar
Information and Communication Technologies (ICT) have relevant positive and negative impacts on environmental sustainability on various levels: First-order effects such as increasing electronic waste streams; second-order effects such as improved energy-efficiency of production; third-order effects such as a product-to-service shift in consumption or rebound effects in transport. In the simulation
An initial-boundary value problem to a system of nonlinear partial differential equations, which consists of a hyperbolic and a parabolic part, is taken into consideration. The problem is discretised by a compact finite difference method. An approximation of the numerical solution is constructed, at which the difference scheme is linearised. Nonlinear convergence is proved using the stability of t
Cooking over open fire with solid fuels results in incomplete combustion and indoor air pollution (IAP) causing respiratory and other diseases leading to nearly two million premature deaths per year. In urban areas, IAP interacts with outdoor pollutants in toxic chemical mixtures affecting also other citizens and damaging regional air quality in terms of 'brown clouds'. Deaths result mainly in wom
This article shows how participation on national, regional and local levels is regulated in the infrastructure of the third generation of mobile telephony, 3G, in Sweden. This regulated participation, the “law in books”, is compared to participation in practice, the “law in action” perspective in the sense of the outcome and functionality of these regulations. This includes the identification of i
Abnormal vascularization of solid tumours results in the development of microenvironments deprived of oxygen and nutrients that harbour slowly growing and metabolically stressed cells. Such cells display enhanced resistance to standard chemotherapeutic agents and repopulate tumours after therapy. Here we identify the small molecule VLX600 as a drug that is preferentially active against quiescent c
Background: Substance use in general has been shown to predict criminal recidivism. The present study aimed to examine potential predictors of criminal recidivism, including substance-specific substance use patterns, in prisoners with substance use. Methods: A cohort of prisoners with substance use problems (N = 4,152) were assessed with the Addiction Severity Index (ASI) in the Swedish criminal j
In this paper is described the preparation of patterned cell dishes to be used in studies of low dose irradiation effects on living cells. Using a droplet microdispenser, an 8 mu m thick polypropylene cell substrate, to which cells do not naturally adhere, was coated in a matrix pattern with the cell adhesive mussel protein Cell-Tak. Cells were shown to adhere and grow on the protein-coated spots,
We report on a gated tunnel diode (GTD) and its operation in a 60 GHz pulsed oscillator, also known as a wavelet generator. The wavelet generator operates with the aid of a reactive bias stabilizing network, which minimizes the DC power consumption. This allows for 60 GHz wavelets as short as 56 ps to be produced, with a corresponding energy consumption of 1.0 pJ, which is a factor of 3.6 lower as
A new method for calibrating the hadron response of a segmented calorimeter is developed and successfully applied to beam test data. It is based on a principal component analysis of energy deposits in the calorimeter layers, exploiting longitudinal shower development information to improve the measured energy resolution. Corrections for invisible hadronic energy and energy lost in dead material in
The review asks how the adaptive filter model of the cerebellum might be relevant to experimental work on zone C3, one of the most extensively studied regions of cerebellar cortex. As far as features of the cerebellar microcircuit are concerned, the model appears to fit very well with electrophysiological discoveries concerning the importance of molecular layer interneurons and their plasticity, t
TASISpec (TASCA in Small Image mode Spectroscopy) combines composite Ge- and Si-detectors for a new detector setup aimed towards multi-coincidence gamma -ray, X-ray, conversion electron, fission fragment, and a-particle spectroscopy of the heaviest nuclei. It exploits the TASCA separator's unique small image focal mode, i.e. the fact that evaporation residues produced in fusion-evaporation reactio
Disasters such as the storms that affected Sweden in 2005 and 2007 showed that citizens initially conducted a large part of the disaster response, such as clearing roads, giving psychosocial support to affected neighbours and repairing power lines in collaboration with power companies. As a result of these storms, an Emergent Citizen Group (ECG) was established in a village which continued to work
Background: Gaucher disease (GD) is the most common inherited lysosomal storage disorder in humans, caused by mutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GBA1). GD is clinically heterogeneous and although the type of GBA1 mutation plays a role in determining the type of GD, it does not explain the clinical variability seen among patients. Cumulative evidence from recent
The aim of this study is to review recent data on dietary fiber (DF) and the glycemic index (GI), with special focus on studies from the Nordic countries regarding cardiometabolic risk factors, type 2 diabetes, cardiovascular disease, cancer, and total mortality. In this study, recent guidelines and scientific background papers or updates on older reports on DF and GI published between 2000 and 20
Background: Day centres are central for community participation among people with mental health problems. Understanding day centre attendees' occupational engagement is therefore important. Method:A total of 88 people from six day centres in four municipalities in southern Sweden completed a time-use diary, recording their occupational engagement during the most recent day at the day centre. The t
This study compared neck range of movement recording using three different methods goniometers (EGM), inclinometers (INC) and a three-dimensional video analysis system (IMG) in simultaneous and synchronized data collection. Twelve females performed neck flexion-extension, lateral flexion, rotation and circumduction. The differences between EGM, INC, and IMG were calculated sample by sample. For fl
The cross section for the diffractive deep-inelastic scattering process ep -> eXp is measured, with the leading final state proton detected in the H1 Forward Proton Spectrometer. The data sample covers the range x(P) < 0.1 in fractional proton longitudinal momentum loss, 0.1 < vertical bar t vertical bar < 0.7 GeV2 in squared four-momentum transfer at the proton vertex and 4 < Q(2) < 700 GeV2 in p
