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HPLC is one of the most widely used analytical techniques in the pharmaceutical industry used for separation and identification of compounds in complex formulations. Despite its advantages, HPLC method development remains challenging. This is due to the need to optimize multiple interdependent parameters simultaneously, while gaining high precision, reproducibility, and efficiency. Even minor cha
This thesis analyzes Socialstyrelsens (Swedish Social Services) guidelines for endometriosis healthcare, with the aim of understanding the social aspects of the medicalized field of endometriosis. Former research on transnational and Swedish endometriosis experience, studies on endometriosis guidelines and Socialstyrelsens’ guidelines for healthcare, is presented to contextualize the project. The
CERN operates complex underground facilities, with the Large Hadron Collider (LHC) posing unique fire detection challenges due to ionising radiation, long tunnel spans, and variable ventilation. To address the limitations of aspirating smoke detectors in both current and future CERN facilities, Distributed Temperature Sensing (DTS) systems using radiation-resistant optical fibers are being exp
As industrial sectors and digital infrastructure expand, the global demand for high-volume, reliable manufacturing of thermal management solutions like heat exchangers continues to accelerate. This thesis investigates the design and optimization of an automated robotic assembly cell for heat exchanger production at Alfa Laval using Discrete Event Simulation (DES). The primary objective was to defi
α-CGRP 8-37 is a peptide fragment of calcitonin gene-related peptide and is commonly used as a CGRP antagonist in pharmacological research. CGRP signaling has been discussed in relation to neuroimmune mechanisms in psoriasis, but a practical development of α-CGRP 8-37 requires analytical methods and formulation strategies that can handle peptide instability, adsorption, and matrix effects. The aim
Energy management in cold logistics is critical for sustainable cold chain transportation. However, conventional reactive temperature control strategies often induce excessive energy consumption and mechanical wear due to rigid air temperature tracking and inability to anticipate system thermal dynamics. Guided by the Design Science Research (DSR) methodology, this study proposes a simulation-base
Increasing demand for lower fuel consumption increases the importance of a higher total energy efficiency in trucks. Since the efficiency of a modern diesel engine is in the range of 40 %, large amounts of waste heat are produced. Recovering this energy can be done with thermoelectric generators. However, these generators’ open load voltage and internal resistance are temperature dependant, which
If adequately adapted, different sources of Lock-in provide new opportunities for companies on mature markets. Neglecting the importance of creating Lock-in in win-win situations could possibly make them victims of their external environment.
Large companies in today’s business environment are to a great extent depending on their credit score by rating institutes like Moody’s and Standard & Poor’s. There is however indications that these big institutes are not always rating companies accurately. This is why this thesis aims at developing a new credit rating model, CRITA-Score, with the objective of determining a company’s financial
This thesis deals with the vital issue of empowerment in development work and development projects, a multimillion dollar enterprise which engages donors,governmental agencies and governments. More specifically the thesis deals with a development intervention in education as social policy in Uruguay, investigated as a case study. The methodological intention is to present the voices of the subject
Lifelong Learning (LLL) involves the formal and informal education and learning of individuals and by extension society in a bid to function efficiently in today’s knowledge world. This Learning is not limited by age, race, or other susceptible circumstances; it is instead encouraged and seen in the contexts of adult learning, continuing learning, and work/ professional learning. By de-facto, it i
This paper examines the emergence of gender-neutral clothing, particularly during the period of 2015-2016 when there was a notable increase in interest surrounding the concepts of gender-neutrality and androgyny in fashion. The objective of this paper is to contribute new research to the field, as there is a lack of specific studies on gender-neutral clothing. To achieve this, the paper conducts i
This study evaluates the protection of fundamental rights within the liability framework of Article 17 of the CDSM Directive. The analysis is conducted under the questions: what are the defining features of the new liability framework of Article 17 CDSMD and its relation to fundamental rights? How has the implementation process of Article 17 affected the balance between fundamental rights? And fin
Intranasal drug delivery is a practical and accessible method for treating localized symptoms as well as achieving systemic drug absorption. The approach takes advantage of the permeability, vascularization, and limited enzymatic activity of nasal tissue, leading to enhanced drug absorption. Moreover, drugs can bypass the blood-brain barrier and directly reach the brain through the olfactory route
In tablet manufacturing, the addition of lubricant to the formulation is of high importance as it ensures smooth compression and ejection of tablets and thereby tablet quality. This study focused on lubrication of tablet formulation using magnesium stearate (MgSt) as a lubricant and microcrystalline cellulose (MCC) as bulk material. Powder blends were analysed to investigate whether an effect of v
Andelen äldre vuxna växer stadigt världen över. År 2030 beräknas en av sex personer i världen att vara 60 år eller äldre. Denna demografiska förändring innebär stora utmaningar för många länder. Bland annat att säkerställa att dagens snabbt växande tekniska utveckling tillgodoser behoven hos äldre vuxna. Flygindustrin är en av de industrier där det går att se en ökning av äldre vuxna bland passageThe demographic group of older adults is growing significantly worldwide. It is predicted that by 2030, one in six people in the world will be aged 60 years or older. This demographic shift presents major challenges for many countries to ensure that the fast-growing technology developments are ready to fulfil the needs of older adults. The flight industry is one of the industries that experience a
MHC genes are extraordinarily polymorphic in most taxa. Host-pathogen coevolution driven by negative frequency-dependent selection (NFDS) is one of the main hypotheses for the maintenance of such immunogenetic variation. Here, we test a critical but rarely tested assumption of this hypothesis—that MHC alleles affect resistance/susceptibility to a pathogen in a strain-specific way, that is, there i
Aim: Risk of treatment-related life-threatening toxicity is high in childhood acute myeloid leukaemia (AML), and access to intensive care units (ICU) is crucial. We explored the ICU admission rate and outcome after intensive care in childhood AML in Sweden. Methods: Patients diagnosed between 2008 and 2016 were identified from the Swedish Childhood Cancer Registry (SCCR), a national quality regist
Functional size, or function points, is a language-independent measure of software size. It is used as an estimator of development effort and software code size, in particular in the domain of information systems, while in real-time systems it is not so widely spread. In this paper, functional size measurements are empirically evaluated by applying them to a recently completed project. Two establi
In the present study, we investigate the combined interaction of mesoporous silica (SiO2) and photocatalytic titanium dioxide (TiO2) nanoparticles with lipid membranes, using neutron reflectometry (NR), cryo-transmission electron microscopy (cryo-TEM), fluorescence oxidation assays, dynamic light scattering (DLS), and ζ-potential measurements. Based on DLS, TiO2 nanoparticles were found to display
