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Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment of N-IF mice significantly reduced inflammation and resulted in the regression of fibrosis, eve
Water security offers to the local population an adequate quality and quantity of water for health, economy, livelihoods and ecosystems. Hence, achieving basic levels of water security should be a priority in areas where access to fresh water is scarce. The Punata alluvial fan (Bolivia) is a semiarid zone and an important agricultural zone, where the main source of water is groundwater. Therefore,
To assess the benefits of introducing Agile practices, it is important to get a clear understanding of the baseline situation, i.e. the situation before their introduction. Without a clear baseline, we cannot properly assess the extent of impacts, both positive and negative, of introducing Agile practices. This paper provides a preliminary guideline to help researchers in capturing and reporting b
A typical approach when designing a bio-inspired robot is to simplify an animal model and to enhance the functionality of interest. For hexapod robots, this often leads to a need of supplementary mechanics to become multifunctional. However, a preferable solution is to employ the embodied multifunctional capabilities of the animal as inspiration for robot design. Using this approach, we present a
The advanced properties of modern materials originate from their nanoscale size and shape and from chemical modifications or doping. Special techniques that can measure the chemical state in the nanoscale are required for exploration and understanding the properties of these materials. While X-ray photoelectron spectroscopy (XPS) can access the necessary chemical information, conventional setups h
In October 2014, the European Council agreed on a target of improving overall energy efficiency by at least 27 per cent by 2030. According to the European Council's conclusions, this target should not be translated into nationally binding targets. Nevertheless individual Member States are free to set higher national objectives if desired. However, it is difficult to assess the degree of ambition o
Background. Arterial spin labeling is an MR imaging technique that measures cerebral blood flow (CBF) noninvasively. The aim of the study is to assess the diagnostic performance of arterial spin labeling (ASL) MR imaging for differentiation between high-grade glioma and low-grade glioma. Methods. Cochrane Library, Embase, Medline, and Web of Science Core Collection were searched. Study selection e
Public procurement for innovation (PPI) is a powerful, underutilized demand-side innovation policy instrument. How this instrument can contribute to meeting societal challenges, which require goaloriented transformation of socio-technical systems, remains unclear and is explored in this article. This article draws on the transitions and PPI literature to propose transformative processes to which P
Rapid urbanization and the growth in the number of motorized vehicles has dramatically marginalized cycling in Chinese cities since the end of the 1990s. The deterioration in air quality and the urban environment is severely challenging urban livability and public health. The cities are seeking effective policies to alleviate these problems, and revitalizing bicycle transport has received increasi
BackgroundAdolescents’ use of alcohol, cannabis and other psychoactive substances has significantly increased in European countries. Parallel to this web-based screening and brief intervention have been disseminated. An important question is if it is based on evidence for effect? Therefore, the aim of this review is to evaluate the evidence for effect. MethodA systematic literature search was per
Following the EU declaration from 2016 on schools as the most crucial places for societal change needed in order to strengthen democracy, this chapter discusses Nordic music education and music education research within the context of shared challenges in times of rapid demographic changes. Resting on emerging results from the authors’ research projects, the first theme to be discussed is music ed
Women with malignant lymphoma, non-Hodgkin's lymphoma and Hodgkin's disease were of a significantly later age at first full-term pregnancy (AFFP) than controls without malignant disorders. The odds ratio (OR) of having the first pregnancy at 30 years of fertility was 6.4 for women with malignant lymphoma. This ratio was higher than the ratio of 3.9 in a group of breast cancer patients. A low parit
This paper presents a design teaching approach that aims to support students to shift their approach when exploring, prototyping and testing user interactions with physical products. This is conducted in a bottom-up, iterative manner to change the perspective from focusing on the opportunities of user-involvement during the form-giving process, rather than prematurely stressing the design outcome.
Control of activated sludge process based on measurement of the dissolved oxygen profile has the distinct advantage of using sensors of proven reliability. These measurements, when coupled with the power of an on-line computer, permit the calculation of important variables which cannot be measured directly. The features of the profile which are of major significance are the position of the maximum
Accurate detection and identification are essential components for epidemiological, ecological, and evolutionary surveys of avian haemosporidian parasites. Microscopy has been used for more than 100 years to detect and identify these parasites; however, this technique requires considerable training and high-level expertise. Several PCR methods with highly sensitive and specific detection capabilit
Cities are key actors in reducing both the causes of climate change (mitigation) and its impact (adaptation), and many have developed separate mitigation and adaptation strategies and measures. However, in order to maximize outcomes, both scholars and practitioners are increasingly calling for more integrated and synergetic approaches. Unfortunately, related research remains scarce and fragmented,
The precise characterization of femtosecond laser pulses is as challenging as their generation and a topic of intense research. Dispersion-scan (d-scan) [1] is a recently established technique where the spectrum of a nonlinear signal, e.g., second-harmonic generation (SHG), is measured as a function of dispersion applied to the pulse. The spectral phase of the pulse can then be retrieved from the
We have developed a novel method to study the influence of surface nanotopography on human fibrinogen adsorption at a given surface chemistry. Well-ordered arrays of nanoholes with different diameters down to 45 nm and a depth of 50 nm were fabricated in silicon by electron beam lithography and reactive ion etching. The nanostructured chip was used as a model system to understand the effect of siz
The bone material from three archaeological occupation phases at Huseby Klev provides the best source of evidence currently available about the subsistence strategies of pioneer settlers in Northern Europe. The results from Huseby Klev indicate that the pioneer settlers initially relied heavily on marine mammals for their sustenance. This subsistence strategy changed during the second and third oc
