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BACKGROUND: The tau-PET radiotracer [18F]flortaucipir enables in vivo detection of tau pathology in Alzheimer's Disease (AD) and has recently been FDA- and EMA-approved for clinical use. To support its implementation, we assessed tau-PET's positive predictive value (PPV) and negative predictive value (NPV) for clinico-pathological AD while accounting for age, amyloid-status, and pre-PET diagnostic
Fluid biomarkers are revolutionizing the diagnosis and management of neurodegenerative diseases by enabling earlier diagnosis and disease monitoring. In particular, blood-based biomarkers have emerged as a minimally invasive and scalable alternative to cerebrospinal fluid analysis. Recent advances in blood-based tau biomarkers have shown high diagnostic accuracy for Alzheimer’s disease (AD). Other
The most prevailing hypothesis regarding mechanisms behind specific language impairment today is the hypothesis of general limitations of processing capacity. Such an hypothesis can hardly be tested by available language assessment tools, especially not by instruments in use for clinical assessment of the lexical-semantic domain in children. Reduced naming speed is by some researchers considered a
This paper is concerned with a recently proposed scalable protocol for vehicle platooning, known as the serial consensus protocol. This achieves coordination of second-order integrator systems through a series connection of first-order conventional consensus protocols, and has been theoretically shown to have advantageous stability and performance properties. We implement this protocol on a vehicl
Circular supply chains (CSCs) depend on enhanced supply chain visibility (SCV) to track and manage resource flows and thereby enable efficient decision-making. Despite confronting silo mentalities, fragmented information, technological barriers, resistance to change, and a lack of standardization, data sharing remains crucial for SCV and circularity. In this study, following the Delphi method, 22
In this paper, we describe centering and noncentering methodology as complementary techniques for use in parametrization of broad classes of hierarchical models, with a view to the construction of effective MCMC algorithms for exploring posterior distributions from these models. We give a clear qualitative understanding as to when centering and noncentering work well, and introduce theory concerni
Strain Comamonas testosteroni TI, capable of degrading the nonionic surfactant (NIS) nonylphenolethoxylate (OP-10), was used for constructing a pilot cellular biosensor. The lower NIS detection limit for the biosensor was 0.25 mg/l. We studied the substrate specificity of the biosensor with respect to a wide range of organic compounds: surfactants, polyaromatic compounds (PAC), carbohydrates, alco
An electrochemical cell has been developed enabling amperometric steady-state- and flow-injection measurements with screen-printed arrays consisting of eight working electrodes (circle divide = 1 mm) arranged radially around a printed Ag/AgCl reference electrode in the centre. The cell contained a rotator, providing similar hydrodynamics over all the working electrodes in the array, which was manu
This manual describes a Matlab toolbox for computational analysis of piecewise linear systems. Key features of the toolbox are modeling, simulation, analysis, and optimal control for piecewise linear systems. The simulation routines detect sliding modes and simulate equivalent dynamics. The analysis and design are based on computation of piecewise quadratic Lyapunov functions. The computations are
Two simplifications for trellis decoding blocks are analyzed in terms of hardware efficiency. Both architectures use a complementary property of the best rate 1/n convolutional codes to reduce arithmetic complexity. While the reduction can be calculated straightforward in the first approach (17%), the other approach relies on modified computational operations and hence this reduction is not as evi
Popular Abstract in Swedish Dagens industriella system är inte långsiktigt hållbara. För detta behövs bland annat fundamentala förändringar av hur samhällets resurser används. Detta gäller den totala volymen som förbrukas men också vilka ämnen som sätts i omlopp i samhället. Därutöver behövs ett mer rättvist utnyttjande av dessa resurser. Industriell ekologi är den vetenskap som studerar de förändToday's industrial systems are regarded to have unsustainable characteristics. In order to acquire a more sustainable state, fundamental changes are needed in the qualitative and quantitative aspects of the resource flows associated with such systems. These need to go hand in hand with a more equitable distribution of the benefits and burdens associated with such resource use. The identification a
BACKGROUND: Endothelium dysfunction is believed to play a role in the development of cardiovascular disease. The aim of the present study was to evaluate the suitability of organ culture as a model for endothelium dysfunction. METHODS: The isometric tension was recorded in isolated segments of the rat mesenteric artery branch, before and after organ culture for 20 h. Vasodilatation was expressed a
We consider a two-echelon distribution inventory system with a central warehouse and a number of retailers. The retailers face stochastic demand. The system is controlled by continuous review installation stock (R,Q) policies with given batch quantities. One way to decentralize the system control is to provide a backorder cost to the warehouse, and let the warehouse choose its reorder point so tha
