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A reliable method of optimization of polymer gears remains, to date, an open challenge, due to the lack of specific material characterization of polymers and to the complex nonlinear relations between different geometric and operating parameters. For spur and helical gears, the authors herein have developed the optimization algorithm, which primarily enables variation of geometry according to vari
In this work, a new set of uniform radiation boundary conditions for a half-space model are derived and applied to a fundamental problem in outdoor sound propagation. This original approach derived here relies upon a high-order family of local radiation boundary conditions related to plane wave reflection coefficients. Validity of the approximation is carried out by examining sound propagation abo
This book provides a wealth of practical guidance on how to design parts to gain the maximum benefit from what additive manufacturing (AM) can offer. It begins by describing the main AM technologies and their respective advantages and disadvantages. It then examines strategic considerations in the context of designing for additive manufacturing (DfAM), such as designing to avoid anisotropy, design
Despite continued efforts by educators, UN declarations and numerous international agreements, progress is still limited in handling major global challenges such as ecosystem collapse, accelerating climate change, poverty, and inequity. The capacity to collaborate globally on addressing these issues remains weak. This historical review of research on global learning for sustainable development (GL
A novel way to formalise the problem of preemptive feedback scheduling is presented, based on discrete-time linear dynamic systems. Despite its extreme simplicity, the obtained formalism is suitable both for representing (and therefore dynamically analysing) existing scheduling methods, and for synthesizing new ones in a totally system-theoretical perspective. Also, by further specialising the cla
The Earth Hologenome Initiative (EHI) is a global collaboration to generate and analyse hologenomic data from wild animals and associated microorganisms using standardised methodologies underpinned by open and inclusive research principles. Initially focused on vertebrates, it aims to re-examine ecological and evolutionary questions by studying host–microbiota interactions from a systemic perspect
Poly-ADP-ribose polymerase-14 (PARP14) can modify proteins and nucleic acids by the reversible addition of a single ADP-ribose molecule. Aberrant PARP14 functions have been related to cancer and inflammation, and its domains are involved in processes related to viral infection. Previous research indicates that PARP14 functions might be mediated via a multitude of target proteins. In vitro studies
This paper compiles a roadmap of considerations concerning zero impact, beyond zero (positive) impact of regenerative development of the construction process. This is described from a process point of view considering the whole lifecycle of a building, involved stakeholders, and the necessity of functional ecosystem services. Firstly, a review is made of the basics of regenerative development and
Formal models for the safety validation of autonomous vehicles have become increasingly important. To this end, we present a safety framework for longitudinal automated driving. This framework enables the calculation of minimum safe inter-vehicular distances for arbitrary ego vehicle control policies in a computationally efficient manner. We use this framework to enhance and generalize the Respons
Software analytics (SA) is frequently proposed as a tool to support practitioners in software engineering (SE) tasks. We have observed that several secondary studies on SA have been published. Some of these studies have overlapping aims and some have even been published in the same calendar year. This presents an opportunity to analyze the congruence or divergence of the conclusions in these studi
The need for autonomous robot systems in both the service and the industrial domain is larger than ever. In the latter, the transition to small batches or even “batch size 1” in production created a need for robot control system architectures that can provide the required flexibility. Such architectures must not only have a sufficient knowledge integration framework. It must also support autonomou
Physical limitations of antennas above infinite perfect electric conductor (PEC) ground planes are determined using the stored electromagnetic energy. Stored energies are computed with the method of moments (MoM) and the image theory. Convex optimization is used to derive the G/Q ratio and Q-factor for a reference geometry, and the results are compared for different antenna types.
Purpose - For eigenvalue problems containing uncertain inputs characterized by fuzzy basic parameters, first-order perturbation methods have been developed to extract eigen solutions, but either the result accuracy or the computational efficiency of these methods is less satisfactory. The purpose of this paper is to present an efficient method for estimation of fuzzy eigenvalues with high accuracy
Genomic manipulation of Yersinia ruckeri, a pathogen of salmonid fish species, is essential for understanding bacterial physiology and virulence. Here, we present a protocol for genomic recombineering in Y. ruckeri, a species reluctant to standard genomic engineering, using CRISPR Cas12a coupled with the λ Red system. We describe steps for identifying protospacer guides, preparing repair template
PurposeThis study investigates how global retailers develop sustainability through network interactions that influence institutionalized sustainability perceptions. The findings enable retailers to drive sustainability systematically and understand the critical internal and external issues.Design/methodology/approachThe study investigates how retailers can work to increase support for sustainabili
We present a xylosylated naphthoxyloside carrying a terminal azide functionality that can be used for conjugation using click chemistry. We show that this naphthoxyloside serves as a substrate for β4GalT7 and induces the formation of soluble glycosaminoglycan (GAG) chains with physiologically relevant lengths and sulfation patterns. Finally, we demonstrate its usefulness by conjugation to the Alex
We describe in this paper the performance under synchrotron radiation of a sealed gaseous detector, Vantec-1, operating at high pressure and less prone to discharges. It is consequently operating at high gain (>105) at high local counting rates up to 106 cps/mm2. To achieve these characteristics, a thin resistive layer is used on a glass plate between the mesh and the readout anode. The performanc
In June 2019, Ruddick was considering how to embed the management of a cryptocurrency in the rural Kenyan communities that were to use it. Initially introduced as paper currencies managed by a cooperative of rural residents, moving the currency system onto the blockchain implied a change in the monetary design. The case describes communal structures that organize economic life in rural Kenya, as w
