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Fast-track (FT) programmes are multimodal, evidence-based approaches to optimize patient outcome after surgery. The aim of this study was to evaluate the safety, clinical outcome and patients' experience of a FT programme after pancreaticoduodenectomy (PD) in a high-volume institution in Sweden.

Summary: Overweight and obesity constitute a major and increasing health and welfare problem throughout the world. Assessing the multifaceted mechanisms – biological, environmental and behavioural – behind this development is a crucial task in medical, social and economic sciences. We are, therefore, grateful to have been given the opportunity to, once again, discuss whether the risk of divorce ma

Cellobiose dehydrogenase catalyses the oxidation of aldoses-a simple reaction, a boring enzyme? No, neither for the envisaged bioelectrochemical applications nor mechanistically. The catalytic cycle of this flavocytochrome is complex and modulated by its flexible cytochrome domain, which acts as a built-in redox mediator. This intramolecular electron transfer is modulated by the pH, an adaptation

The polyamines are important for a variety of cellular functions, including cell growth. Their intracellular concentrations are controlled by a complex network of regulatory mechanisms, in which antizyme (Az) has a key role. Az reduces the cellular polyamine content by down-regulating both the enzyme catalysing polyamine biosynthesis, ornithine decarboxylase (ODC), and the uptake of polyamines. Th

We consider the problem of decomposing a video sequence into a superposition of (a given number of) moving layers. For this problem, we propose an energy minimization approach based on the coding cost. Our contributions affect both the model (what is minimized) and the algorithmic side (how it is minimized). The novelty of the coding-cost model is the inclusion of a refined model of the image form

The escape process from the native valley for proteins subjected to a constant stretching force is examined using a model for a beta barrel. For a wide range of forces, the unfolding dynamics can be treated as one-dimensional diffusion, parametrized in terms of the end-to-end distance. In particular, the escape times can be evaluated as first passage times for a Brownian particle moving on the pro

The site–site Ornstein–Zernike equation with a simple mean spherical closure is used to study electrostatic interactions of proteins. Using a Debye–Hückel approximation for the correlation functions of the bulk electrolyte and a simple basis expansion for the protein–salt direct correlation functions, we obtain a very simple variational expression for the electrostatic component of the excess chem

The latency and amplitude of the midlatency auditive evoked potential's (AEP) Nb-trough has been found to indicate the depth of anaesthesis. The aim of this paper is to present a system that reliably estimates these parameters without a long time delay. The result shows that it is possible to estimate and track changes in latency and amplitude of the Nb-trough with a delay below 1 minute at a stim

Integrated development environments have provided increasingly powerful tools for software creation, and yet the creation of complex computer programs remains difficult and time-consuming. Liveness in a programming environment has been identified as one direction in which to pursue further improvements in programmer productivity. We propose a scheme for achieving strategically predictive liveness, t

Purpose: Although business models that deliver sustainability are increasingly popular in the literature, few tools that assist in sustainable business modelling have been identified. This paper investigates how businesses might create balanced social, environmental and economic value through integrating sustainability more fully into the core of their business. A value mapping tool is developed t

This article presents a comprehensive integration of current experimental evidence and theories about so-called parapsychological (psi) phenomena. Throughout history, people have reported events that seem to violate the common sense view of space and time. Some psychologists have been at the forefront of investigating these phenomena with sophisticated research protocols and theory, while others h

Electroactive polymers with time-dependent behavior are considered in the present paper by way of a new physics-based micromechanical model; such viscoelastic response is described by the internal evolution of the polymer network, providing a new viewpoint on the stress relaxation occurring in elastomers. The main peculiarity of such internally rearranging materials is their capacity to locally re

Heusler compounds are a ripe platform for discovery and manipulation of emergent properties in topological and magnetic heterostructures. In these applications, the surfaces and interfaces are critical to performance; however, little is known about the atomic-scale structure of Heusler surfaces and interfaces or why they reconstruct. Using a combination of molecular beam epitaxy, core-level and an

We study a linear quadratic control problem for transportation optimization on a directed line graph. We show that the solution to the Riccati equation associated with this problem is highly structured. The feedback law is almost upper triangular, and the synthesis of the feedback law is given by a recursion, making it scalable. The structure of the feedback law also allows for an efficient realiz

The choice of hyperparameter(s) notably affects the support recovery in LASSO-like sparse regression problems, acting as an implicit model order selection. Parameters are typically selected using cross-validation or various ad hoc approaches. These often overestimates the resulting model order, aiming to minimize the prediction error rather than maximizing the support recovery. In this work, we pr