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For development and evaluation of methods for predicting the effects of variations, benchmark datasets are needed. Some previously developed datasets are available for this purpose, but newer and larger benchmark sets for benign variants have largely been missing. VariSNP datasets are selected from dbSNP. These subsets were filtered against disease-related variants in the ClinVar, UniProtKB/Swiss-
Biocatalysis has the potential to provide the chemical industry with several advantages for the production of chemicals; but the use of this technology for the production of speciality and bulk chemicals is unfortunately limited due to the high costs related to the production of the biocatalyst. We have immobilized Candida antarctica lipase B (CALB) on different resins in order to obtain a more co
The current most serious side effect of haemophilia treatment is inhibitor development. Significant progress has been made over the last decades to understand why this complication occurs in some patients and it seems clear that both genetic and non-genetic factors are involved. Several issues however remain to be settled. A review was undertaken to summarise some key findings regarding the curren
A one-dimensional continuum-mechanical model of axonal elongation due to assembly of tubulin dimers in the growth cone is presented. The conservation of mass leads to a coupled system of three differential equations. A partial differential equation models the dynamic and the spatial behaviour of the concentration of tubulin that is transported along the axon from the soma to the growth cone. Two o
The protecting group tetraisopropyldisiloxane-1,3-yl has been investigated for simultaneous protection of two hydroxyls on pentopyranosides. Methyl α-d-xylopyranoside is protected in excellent regioselectivity and high yield to form the 2,3-protected xylopyranoside whereas methyl β-d-xylopyranoside gives the 3,4-protected product also with excellent regioselectivity.
We use randomness to exploit the potential sparsity of the Boolean matrix product in order to speed up the computation of the product. Our new fast outputsensitive algorithm for Boolean matrix product and its witnesses is randomized and provides the Boolean product and its witnesses almost certainly. Its worst-case time performance is expressed in terms of the input size and the number of non-zero
A new vessel for simultaneous isothermal calorimetry and respirometry (calorespirometry) on terrestrial (non-aqueous) samples has been developed. All types of small (<1g) biological samples (insects, soil, leaves, fungi, etc.) can be studied. The respirometric measurements are made by opening and closing a valve to a vial inside the sample ampoule containing a carbon dioxide absorbent. Typically a
Global environmental change is real and everywhere, and so is inequality. Such a warmer, stormier, and divided world will create highly differentiated socioecological impacts and responses to climate change with stronger effects on people, places, and livelihoods that contributed the least. This necessitates mitigation, adaptation, and a solid understanding of their interactions with persistent pr
The conversion of a blood meal into viable offspring is a central physiological challenge for female mosquitoes. A new study has found that rectal pad cells function as a peripheral neuroendocrine hub, sensing feeding-related signals and regulating reproductive investment, linking the hindgut to reproductive decision-making.
The Transformer architecture has been successful across many domains, including natural language processing, computer vision and speech recognition. In keyword spotting, self-attention has primarily been used on top of convolutional or recurrent encoders. We investigate a range of ways to adapt the Transformer architecture to keyword spotting and introduce the Keyword Transformer (KWT), a fully se
While Bayesian Optimization (BO) is a very popular method for optimizing expensive black-box functions, it fails to leverage the experience of domain experts. This causes BO to waste function evaluations on bad design choices (e.g., machine learning hyperparameters) that the expert already knows to work poorly. To address this issue, we introduce Bayesian Optimization with a Prior for the Optimum
Purpose: Sinonasal malignancies (SNM) represent a rare and complex group of cancers that includes a wide range of histopathological subtypes. Data from population-based cohorts are scarce but warranted as a basis for randomized controlled treatment trials (RCTs). Our aim was to assess overall and histology subset-specific outcomes for SNM patients treated at a tertiary referral centre. Methods: A
Current criteria for the diagnosis of CKD in adults include persistent signs of kidney damage, such as increased urine albumin-to-creatinine ratio or a GFR below the threshold of 60 ml/min per 1.73 m2 This threshold has important caveats because it does not separate kidney disease from kidney aging, and therefore does not hold for all ages. In an extensive review of the literature, we found that G
A process for synthesis of a polymeric polyalcohol substantially and preferably built up form polyester units and composed of a monomeric or polymeric initiator molecule to which at least one dentritic branch (dendron) consisting of a number of branching generations is added. The branching generations comprise a polymericor monomeric branching chain extender having three reactive functions of whic
We present a xylosylated naphthoxyloside carrying a terminal azide functionality that can be used for conjugation using click chemistry. We show that this naphthoxyloside serves as a substrate for β4GalT7 and induces the formation of soluble glycosaminoglycan (GAG) chains with physiologically relevant lengths and sulfation patterns. Finally, we demonstrate its usefulness by conjugation to the Alex
We describe in this paper the performance under synchrotron radiation of a sealed gaseous detector, Vantec-1, operating at high pressure and less prone to discharges. It is consequently operating at high gain (>105) at high local counting rates up to 106 cps/mm2. To achieve these characteristics, a thin resistive layer is used on a glass plate between the mesh and the readout anode. The performanc
In June 2019, Ruddick was considering how to embed the management of a cryptocurrency in the rural Kenyan communities that were to use it. Initially introduced as paper currencies managed by a cooperative of rural residents, moving the currency system onto the blockchain implied a change in the monetary design. The case describes communal structures that organize economic life in rural Kenya, as w
The study presents a critical analysis of unequal social geographies in the city of Tehran. It aims to identify degrees of access to different aspects of social reproduction with particular attention to the worse-off districts. The issue of unevenness in Tehran has been discussed by Iranian economists and geographers criticizing bad policies, undemocratic state, and corruption. However, political
This master thesis project has been performed in cooperation with TAC, a building automation company in Malmö and the Department of Automatic Control at LTH. TAC has experienced problems for some time with their PID controllers. This master thesis has therefore investigated the use of PID control at TAC, the problems with the existing controllers. The thesis also describes a new PID controller tha
