Sökresultat

IMPORTANCE In age-related macular degeneration (AMD), rare variants in the complement system have been described, but their functional consequences remain largely unexplored. OBJECTIVES To identify new rare variants in complement genes and determine the functional effect of identified variants on complement levels and complement regulation in serum samples from carriers and noncarriers. DESIGN, SE

It is well established that high ambient heat could cause congenital abnormalities resulting in miscarriage or stillbirth among certain species of mammals. However, this has not been systematically studied in real field settings among humans, despite the potential value of such knowledge for estimating the impact of global warming on the human species. This study sought to test the hypothesis that

Context. Parallaxes for 331 classical Cepheids, 31 Type II Cepheids, and 364 RR Lyrae stars in common between Gaia and the Hipparcos and Tycho-2 catalogues are published in Gaia Data Release 1 (DR1) as part of the Tycho-Gaia Astrometric Solution (TGAS). Aims. In order to test these first parallax measurements of the primary standard candles of the cosmological distance ladder, which involve astrom

To cite this article: Cai G-H, Hashim JH, Hashim Z, Ali F, Bloom E, Larsson L, Lampa E, Norbäck D. Fungal DNA, allergens, mycotoxins and associations with asthmatic symptoms among pupils in schools from Johor Bahru, Malaysia. Pediatr Allergy Immunol 2011; 22: 290-297. ABSTRACT: While there is a large variation of prevalence of asthma symptoms worldwide, what we do know is that it is on the rise in

Importance: Prenatal exposure to phthalates has been associated with neurodevelopmental outcomes, but little is known about the association with language development. Objective: To examine the association of prenatal phthalate exposure with language development in children in 2 population-based pregnancy cohort studies. Design, Setting, and Participants: Data for this study were obtained from the

BACKGROUND: Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015.METHODS: For countri

Supply chain risk management_v2 CenCIP  Professional  Papers     Nummer  3,  November  2016   Centre  for  Critical  Infrastructure  Protection  research  (CenCIP)   Websida:  www.cencip.lu.se       1.    Den   svenska   supply   chain-­‐ panelen     I  maj   2013   etablerades  den   svenska   supply   chain-­‐‑panelen  av   forskare   från   Institutionen   för   teknisk   ekonomi   och   logist

https://www.cencip.lu.se/sites/cencip.lu.se/files/nr_3-supply_chain_risk_management.pdf - 2026-06-08

Ambient fine particulate matter PM2.5 (particles with a diameter smaller than 2.5 μm) has been associated with cardiovascular and respiratory morbidity and mortality. It has been shown that biomass burning for heat production purposes can generate large amounts of fine particles. Thus characteristics of particle emissions from biofuel combustion may be important in the assessment of health effects

pnas201305623 1..10 TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity Mickael Decressaca,1, Bengt Mattssona, Pia Weikopb, Martin Lundblada, Johan Jakobssona, and Anders Björklunda,1 aDepartment of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, 22184 Lund, Sweden; and bLaboratory of Neuropsychiatry, Rigshospitalet University Hospita

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/decressac_et_al._pnas_2013.pdf - 2026-06-08

Lagar och regler vid renovering - en översikt E L I S A B E T H H E L S I N G | Rapport nr 2016:2 L a g a r o c h r e g l e r v i d r e n o v e r i n g 2 Lagar och regler vid renovering - En översikt Elisabeth Helsing CBI Betonginstitutet AB Sustainable Integrated Renovation Rapport 2016:2 L a g a r o c h r e g l e r v i d r e n o v e r i n g 3 Innehållsförteckning 1 1. Syfte och omfattning 4 2. S

https://www.renoveringscentrum.lth.se/sites/renoveringscentrum.lth.se/files/2025-09/2016_2_Lagar_och_regler_vid_renovering.pdf - 2026-06-08

Beyond CP Snow 2 Beyond CP S now Many of the challenges we face in the 21st century deal with issues that demand a deepened understanding of the interplay between the biophysical world, humans, society and technology. Research and education stand upon a founding structure with rather distinct borders between the different traditions. As a result, the methods, theories, models, concepts and thought

https://www.cec.lu.se/sites/cec.lu.se/files/oberg_2011_beyond_cp_snow.pdf - 2026-06-08

Importance: Novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain tau aggregates in Alzheimer disease. Objective: To determine which plasma biomarker combinations can accurately detect tau pathological brain changes in Down syndrome (DS). Design, Setting, and Participants: The cross-sectional, multicenter Alzheimer's Biomarker Consortium-Down Syndrome study included adul

Objectives To examine whether multimorbidity aggregates in families in Sweden.Design National explorative family study.Setting Swedish Multigeneration Register linked to the National Patient Register, 1997-2015. Multimorbidity was assessed with a modified counting method of 45 chronic non-communicable diseases according to ICD-10 (international classification of diseases, 10th revision) diagnoses.

Background: Various factors modulate circulating testosterone in men, affecting interpretation of testosterone measurements. Purpose: To clarify factors associated with variations in sex hormone concentrations. Data Sources: Systematic literature searches (to July 2019). Study Selection: Prospective cohort studies of community-dwelling men with total testosterone measured using mass spectrometry.

Background: Hypertension is the leading risk factor for cerebral small vessel disease. We aimed to determine whether antihypertensive drug classes differentially affect microvascular function in people with small vessel disease. Methods: We did a multicentre, open-label, randomised crossover trial with blinded endpoint assessment at five specialist centres in Europe. We included participants aged

Background: Several aggregate data meta-analyses have provided estimates of the effectiveness of influenza vaccination in community-dwelling elderly people. However, these studies ignored the effects of patient-level confounders such as sex, age, and chronic diseases that could bias effectiveness estimates. We aimed to assess the confounder-adjusted effectiveness of influenza vaccines on laborator

BACKGROUND: Alzheimer's disease is characterized by an abnormal increase of phosphorylated tau (pTau) species in the CSF. It has been suggested that emergence of different pTau forms may parallel disease progression. Therefore, targeting multiple specific pTau forms may allow for a deeper understanding of disease evolution and underlying pathophysiology. Current immunoassays measure pTau epitopes

BACKGROUND: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.METHODS: We estimated prevalence, incidence, d

Non-traditional stable isotope systems are increasingly used to study micronutrient cycling and acquisition in terrestrial ecosystems. We previously proposed for zinc (Zn) a conceptual model linking observed isotope signatures and fractionations to biogeochemical processes occurring in the rice soil environment and we suggested that 2’deoxymugineic acid (DMA) could play an important role for rice

The thesis concerns glycosyl transfer with use of b-glycosidases, most of them from hyperthermophilic organisms. Both optimisation of the reaction conditions and protein engineering in terms of site-directed mutagenesis were used to improve b-glycosidase-catalysed reactions. The first part of the work deals with conversion of lactose into valuable products such as galacto-oligosaccharides (GOS) an