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More than a decade ago the WHO Health Promoting Hospitals project was initiated in order to support hospitals towards placing greater emphasis on health promotion and disease prevention, rather than on diagnostic and curative services alone. Twenty hospitals in eleven European countries participated in the European pilot project from 1993 to 1997. Since then, the International Network of Health Pr
The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. If the optic nerve is transected (ONT), adult RGCs die by a form of cell death called apoptosis, and a general hypothesis is that neurotrophic factors can support the survival of injured neurons.With the intention to The focus of this thesis is the life and death of adult retinal ganglion cells (RGCs). RGCs are neurons that convey visual information from the retina to higher centers in the brain. If the optic nerve is transected (ONT), adult RGCs die by a form of cell death called apoptosis, and a general hypothesis is that neurotrophic factors can support the survival of injured neurons. With the intention to
X-rays allow to non-destructively investigate biological, chemical or physical processes at thenano-scale. Their high penetration depth in matter allows to investigate samples even in-side sample environments, which would be difficult with complementary methods such astransmission electron microscopy (TEM). The microscopy technique ptychography has beenestablished in X-ray imaging in recent years.X-rays allow to non-destructively investigate biological, chemical or physical processes at the nano-scale. Their high penetration depth in matter allows to investigate samples even inside sample environments, which would be difficult with complementary methods such as transmission electron microscopy (TEM). The microscopy technique ptychography has been established in X-ray imaging in recent year
We report the development of a platform of dual targeting Fab (DutaFab) molecules, which comprise two spatially separated and independent binding sites within the human antibody CDR loops: the so-called H-side paratope encompassing HCDR1, HCDR3 and LCDR2, and the L-side paratope encompassing LCDR1, LCDR3 and HCDR2. Both paratopes can be independently selected and combined into the desired bispecifWe report the development of a platform of dual targeting Fab (DutaFab) molecules, which comprise two spatially separated and independent binding sites within the human antibody CDR loops: the so-called H-side paratope encompassing HCDR1, HCDR3 and LCDR2, and the L-side paratope encompassing LCDR1, LCDR3 and HCDR2. Both paratopes can be independently selected and combined into the desired bispecif
The addition of Cr is known to work as an effective prevention against oxidation in Fe-based alloys. This can be attributed to the peripheral oxide, the structure of which is dependent on the composition of the alloy. Using Molecular Dynamic (MD) calculations with a Reactive Force Field (ReaxFF) potential, we successfully identify several oxide structures arising during initial oxide formation in The addition of Cr is known to work as an effective prevention against oxidation in Fe-based alloys. This can be attributed to the peripheral oxide, the structure of which is dependent on the composition of the alloy. Using Molecular Dynamic (MD) calculations with a Reactive Force Field (ReaxFF) potential, we successfully identify several oxide structures arising during initial oxide formation in
This study explores the control degree in success criteria operationalization. A literature review reveals that control degree relates to two patterns operationalizing success criteria: one directed to measurement and measure selection; the other directed to operationalization through the conceptualization of a relationship between a specific factor and project success. While in both patterns tighThis study explores the control degree in success criteria operationalization. A literature review reveals that control degree relates to two patterns operationalizing success criteria: one directed to measurement and measure selection; the other directed to operationalization through the conceptualization of a relationship between a specific factor and project success. While in both patterns tigh
Post hoc interventions rely on having access to certain personal data - such as the gender, age, ethnicity, and sexual orientation of the persons being evaluated - in order to detect and correct for prejudice. This brings these interventions into possible tension with pertinent data protection legislation, which might restrict the processing of said data. We discuss the compatibility of post hoc iPost hoc interventions rely on having access to certain personal data - such as the gender, age, ethnicity, and sexual orientation of the persons being evaluated - in order to detect and correct for prejudice. This brings these interventions into possible tension with pertinent data protection legislation, which might restrict the processing of said data. We discuss the compatibility of post hoc i
Due to their potential environmental risk, the abatement of organic micropollutants from wastewater has gained increasing attention in recent years. This thesis evaluates the use of ozone in Swedish wastewater treatment plants (WWTPs) and the incentives for full-scale implementation of organic micropollutant removal.This work is divided into two sections: the first segment comprises quantitative r
Nearly 60% of the worlds adult population is projected to be overweight or obese by 2030. The prevalence of obesity- related diseases, such as type 2 diabetes (T2D), has increased markedly in the past decades. The adipose tissue plays an important role in disease progression of T2D. Adipocyte insulin sensitivity, adipose tissue’s ability to expand, and accumulation of subcutaneous rather than visc
Popular Abstract in English The Andean region and the Amazon Basin of South America have been identified as regions of origin and the domestication of many plants. Some of the food crops from these regions such as potato and cassava, have gained global import¬ance, while the majority of food crops are hardly know outside their present area of cultivation. In the first part of this study, underutiBoth the nutritional and functional properties of starch are directly influenced by the molecular structure of its polymers: amylose and amylopectin. It is therefore important to have reproducible methods for quantifying the molecular size. In the first part of the thesis, the composition, crystallinity, degree of branching, morphological, thermal and pasting properties, and susceptibility of the
When the coronavirus spread globally in early 2020, many governments issued national lock downs of schools, institutions, and businesses. As the epidemic turned into a pandemic, the health crisis also became a societal crisis, and many universities and research foundations issued COVID-19 grants to study the societal implications of the crisis. In this article, we discuss sociological research dur
OECD delivered on October 5th 2015 the BEPS final package consisting of 15 actions intending to address the issues of base erosion and profit shifting. The aim of Action 6 is to prevent treaty abuse, in particular treaty shopping. To achieve this goal, a specific anti- abuse rule, a Limitation- on- Benefit (LOB) rule, will be included in the OECD Model. The LOB rule contains objective tests that t
This thesis studies three ideas represented in the political work Rukhnama written by Türkmenbaşy, the former totalitarian dictator of Turkmenistan. Using the theories of Anderson in Imagined communities, with the method of descriptive idea analysis, it comes to the conclusion that the work represents a heavily authoritarian ideology with its basis in a family structure. The family structure is pa
In recent years, plastic waste trade has received increasing attention due to huge amounts ending up in countries with high rates of mismanaged plastic waste and the environmental damage of plastic pollution. The EU has been exporting plastic waste to China for recycling purposes due to insufficient domestic recycling capacities, until 2018, when China decided to ban all imports of plastic waste.
In this critical idea-analysis of the relation between Sweden and the Nordic Council the author sifts out two construcions of identity and tests if there is a discrepancy to be found between what the member state grows within its borders and also sign by being a part of the nordic cooperation. In this study the analysis dive into the origins of scandinavism and nordism and discover touching points
The purpose of this study is to understand how we talk and write about and our understanding of crimes, the perpetrator and victims. By using a gender discourse analysis of the media reporting of a specific crime committed in Sweden, “Knutbydramat” with two perpetrators of different sexes, we aim to see how the media represent and therefore consolidate the social norms in a society. The discourse
The number of people escaping from wars and conflicts to European welfare states is increasing. Many of them are children; some come as unaccompanied minors (UMs), fleeing without parents or any other responsible family member, entering and living in the country of refuge on their own. The “United Nations” (UN) and its “Convention on the Rights of the Child” from 1989 secures them special protecti
The importance of sustainable and effective energy usage is rapidly growing. SWEP International AB leads the manufacturing of brazed plate heat exchangers that offer effective heating and cooling applications used in various systems and industries. Stud bolts are manually welded onto the heat exchanger surface in their manufacturing process. A project to fully automate this process using an indust
