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Objectives. There is a need for an observation scale for assessment and monitoring of acutely psychotic patients. Milestones based on such ratings should be defined, similar to the PANSS-based Remission criteria. FAST-O is such an instrument (11 items and a CGI rating). Methods. Reliability, validity and factor structure were analyzed in four separate studies-most importantly in one study of 33 ch
BACKGROUND: CYP2J2 is responsible for the production of 5,6 8,9 11,12 and 14,15-epoxyeicosatrienoic acids, vasodilator and anti-inflammatory substances. It is abundantly expressed in human heart and also present in kidney and vasculature. Carriers of a common polymorphism, the CYP2J2-50G>T, rs890293, have reduced expression of CYP2J2 mRNA level in the heart putatively through the interference with
Proline-rich regions have been identified in many surface proteins of pathogenic streptococci and staphylococci. These regions have been suggested to be located in cell wall-spanning domains and/or to be required for surface expression of the protein. Because little is known about these regions, which are found in extensively studied and biologically important surface proteins, we characterized th
In search for remedies and treatments, science has recurred to Mother Nature. This is where galiellalactone was found, a fungal metabolite isolated from Galiella rufa in 1990. Since then chemists and biologists have been studying its properties and found it to be a potential candidate against castration-resistance prostate cancer (CRPC). The development of a new drug requires many studies of the c
The Background: Immigrant children's education is a very complex phenomenon that requires a special approach from pedagogues and country authorities. It cannot be neglected, otherwise the future consequences can be frustrating. According to the Swedish governmental policy, immigrant children should have the same rights for education as Swedish pupils. They should also have the right to preserv
This thesis critically examines the issue of shared border sewage between San Diego and Tijuana. In light of the recent sewage spill in February of 2017, dumping 143 million gallons of raw sewage into the Tijuana River, the phenomena of border sewage in the transnational environment of the Tijuana River Watershed has been a topic of interest in local and international contexts; raising questions o
The following thesis is concerned with understanding the motivational factors behind Georgian jihadis’ decision to join the Islamic State. It uses the theory of the Islamisation of radicalism to explain the process of radicalisation in Georgia. Resting on a mixed methods research design, the thesis aims to study the individual stories of Georgians fighting for the Islamic State in order to underst
Objectives: To study bone shape changes as a potential early feature of post-traumatic structural knee OA development, we estimated the association between meniscal status in the anterior cruciate ligament (ACL) injured knee and longitudinal condyle changes in bone surface area. Design: We used data from the KANON trial, including 121 young ACL-injured adults. We obtained baseline and 2-year follo
Lymphocytes from human peripheral blood have been separated by countercurrent distribution in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000 with a cell yield of 59–88% and viability above 90%. A highly reproducible partition pattern was seen with four distinct peaks. Lymphocytes with surface membrane immunoglobulin (SmIg) were located in the first part o
Background: A possible connection on vascular basis between impaired kidney function and cognitive dysfunction has been suggested in previous studies. Contradictory results regarding specific cognitive domains have been reported. The aim for this study was to investigate the association between kidney function and specific cognitive domains. Methods: In this cross-sectional design, data from the g
In the seminal cases C-156/21 and C-157/21 (‘Budget Conditionality Cases’) the Court of Justice of the European Union demonstrated a shift in the perception of the operational functionality of foundational values of the EU, establishing that the rule of law is a founding value of the Union which represents a legal norm and imposes an obligation on the Member States to comply with its constituent e
This keynote lecture presents and analyses the so-called Berlin Theses, the formal name of which is "A Time for Recommitment", a dialogue document presented and approved by the International Council of Christians and Jews.
BackgroundChildren with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We performed a population-based, longitudinal cohort study of the risk of depression and anxiety in south-Swedish patients with juvenile arthritis.MethodsThe south-Swedish JIA cohort (n = 6
Cognitive semiotics is understood here to consist in the merger of the two great transdisciplinary endeavours (re)emerging in the middle of the last century, semiotics and cognitive science, the common core of which may consist in the phenomenological perspective, in both Husserl’s and Peirce’s sense of the term. We explore and revise Louis Prieto’s characterization of the semiotic sciences, traci
Hazel (Corylus avellana) has been abundant in the vegetation of northern and central Europe since the early Holocene and has provided food and materials for humans ever since. Here we use stable carbon isotope (δ13C) values of hazelnut shells to infer woodland openness based on the premise of the “canopy effect”. It is well established that plants growing in dense, shaded forests have lower carbon
Antibody radionuclide conjugates are an emerging modality for targeted imaging and potent therapy of disseminated disease. Coupling of radionuclides to monoclonal antibodies (mAbs) is typically achieved by applying non-site-specific labelling techniques. With the ambition of reducing variability, increasing labelling efficacy and stability, several site-specific conjugation strategies have been de
