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The 13-amino acid glycopeptide tx5a (Gla-Cys-Cys-Gla-Asp-Gly-Trp*-Cys-Cys-Thr*-Ala-Ala-Hyp-OH, where Trp* = 6-bromotryptophan and Thr* = Gal-GalNAc-threonine), isolated from Conus textile, causes hyperactivity and spasticity when injected intracerebral ventricularly into mice. It contains nine post-translationally modified residues: four cysteine residues, two gamma-carboxyglutamic acid residues,

Proline-rich regions have been identified in many surface proteins of pathogenic streptococci and staphylococci. These regions have been suggested to be located in cell wall-spanning domains and/or to be required for surface expression of the protein. Because little is known about these regions, which are found in extensively studied and biologically important surface proteins, we characterized th

We assessed the interaction between the APOE epsilon 4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE epsilon 4 predicted the onset of AD-type dementia in middle (HR 3.45 9

This keynote lecture presents and analyses the so-called Berlin Theses, the formal name of which is "A Time for Recommitment", a dialogue document presented and approved by the International Council of Christians and Jews.

BACKGROUND: CYP2J2 is responsible for the production of 5,6 8,9 11,12 and 14,15-epoxyeicosatrienoic acids, vasodilator and anti-inflammatory substances. It is abundantly expressed in human heart and also present in kidney and vasculature. Carriers of a common polymorphism, the CYP2J2-50G>T, rs890293, have reduced expression of CYP2J2 mRNA level in the heart putatively through the interference with

Cognitive semiotics is understood here to consist in the merger of the two great transdisciplinary endeavours (re)emerging in the middle of the last century, semiotics and cognitive science, the common core of which may consist in the phenomenological perspective, in both Husserl’s and Peirce’s sense of the term. We explore and revise Louis Prieto’s characterization of the semiotic sciences, traci

BackgroundChildren with chronic diseases are reported to have increased risk of psychiatric comorbidity. Few studies have investigated this risk in juvenile idiopathic arthritis (JIA), with conflicting results. We performed a population-based, longitudinal cohort study of the risk of depression and anxiety in south-Swedish patients with juvenile arthritis.MethodsThe south-Swedish JIA cohort (n = 6

Bulk properties of cortical bone have been well characterized experimentally, and potent toughening mechanisms, e.g., crack deflections, have been identified at the microscale. However, it is currently difficult to experimentally measure local damage properties and isolate their effect on the tissue fracture resistance. Instead, computer models can be used to analyze the impact of local characteri

A directional crack growth prediction in a compressed homogenous elastic isotropic material under plane strain conditions is considered. The conditions at the parent crack tip are evaluated for a straight stationary crack. Remote load is a combined biaxial compressive normal stress and pure shear. Crack surfaces are assumed to be frictionless and to remain closed during the kink formation wherefor

Lymphocytes from human peripheral blood have been separated by countercurrent distribution in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000 with a cell yield of 59–88% and viability above 90%. A highly reproducible partition pattern was seen with four distinct peaks. Lymphocytes with surface membrane immunoglobulin (SmIg) were located in the first part o

Background: A possible connection on vascular basis between impaired kidney function and cognitive dysfunction has been suggested in previous studies. Contradictory results regarding specific cognitive domains have been reported. The aim for this study was to investigate the association between kidney function and specific cognitive domains. Methods: In this cross-sectional design, data from the g

Globalization has resulted in more segments and product configurations to meet the needs of various customers in different markets. For manufacturers to keep up, the operations footprint has become more global to source from the most appropriate suppliers but also have manufacturing sites in close proximity to the main local markets. The relationship between the products offered, in particular the

The Background: Immigrant children's education is a very complex phenomenon that requires a special approach from pedagogues and country authorities. It cannot be neglected, otherwise the future consequences can be frustrating. According to the Swedish governmental policy, immigrant children should have the same rights for education as Swedish pupils. They should also have the right to preserv

In this thesis, the question of how to balance the right to reindeer herding against competing interests of land use in Sápmi in accordance with the indigenous rights of the Sami, will be examined. In order to answer this question other questions needs to be answered – What is the right to reindeer herding? Who is the holder of the right? Where can the right be exercised and finally, how can the r

This thesis takes on a case study approach and investigates the populist radical right party Alternative für Deutschland’s opposition towards the coal phase-out in Germany. The party is known for its contrarian position towards (human-made) climate change. Drawing on literature that investigates the populist radical right as well as climate change denial (also referred to as ‘scepticism’), a frami

This thesis critically examines the issue of shared border sewage between San Diego and Tijuana. In light of the recent sewage spill in February of 2017, dumping 143 million gallons of raw sewage into the Tijuana River, the phenomena of border sewage in the transnational environment of the Tijuana River Watershed has been a topic of interest in local and international contexts; raising questions o

The following thesis is concerned with understanding the motivational factors behind Georgian jihadis’ decision to join the Islamic State. It uses the theory of the Islamisation of radicalism to explain the process of radicalisation in Georgia. Resting on a mixed methods research design, the thesis aims to study the individual stories of Georgians fighting for the Islamic State in order to underst