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Context: Childhood ketotic hypoglycemia ( KH) is a disease characterized by fasting hypoglycemia and increased levels of ketone bodies. The cause is unknown. Objective: The objective of the study was to study a pair of homozygotic twin boys, one of whom had severe KH from the age of 14 months, whereas the other boy was apparently healthy. Design and Results: At the age of 6 yr, the boys were thoro
Chronic exposure of pancreatic islets to elevated plasma lipids ( lipotoxicity) can lead to beta-cell dysfunction, with overtime becoming irreversible. We examined, by confocal microscopy and biochemistry, whether the expression of islet inducible nitric oxide synthase ( iNOS) and the concomitant inhibition of glucose-stimulated insulin release seen after lipid infusion in rats was modulated by th
OBJECTIVE: The time taken to reach maximal haemostatic effect following local anaesthesia with epinephrine is generally believed to be <10 min. This is based on clinical experience and indirect measurements of perfusion using methods such as laser Doppler flowmetry and oxygen spectroscopy. However, the only study in which bleeding has been measured quantitatively in an intra-operative setting in h
Scope of practice and in-country distribution of surgical providers in low-income countries remains insufficiently described. Through a nationwide comprehensive inventory of surgical procedures and providers in Sierra Leone, we aimed to present the geographic distribution, medical training, and productivity of surgical providers in a low-income country.
In this paper Nordic Noir, in its filmic and televisual incarnations, will be considered on its relative merits as a transnationally successful, but regionally based popular cultural expression. The inquiry will be conducted against a backdrop which briefly traces the history and some of the obstacles which historically have limited the transnational circulation of European popular culture. Conseq
Background The outcome of axillary ultrasound (AUS) with fine-needle aspiration biopsy (FNAB) in the diagnostic work-up of primary breast cancer has an impact on therapy decisions. We hypothesize that the accuracy of AUS is modified by nodal metastatic burden and clinico-pathological characteristics. Material and methods The performance of AUS and AUS-guided FNAB for predicting nodal metastases wa
Regulation of syncytiotrophoblast intracellular pH is critical to optimum enzymatic and transport functions of the placenta. Previous studies of Na+/H+ exchanger (NHE) activity in the placenta from pregnancies complicated by intrauterine growth restriction (IUGR) have produced conflicting results. The possible role of altered placental pH regulation in the development of acidosis in some fetuses s
This thesis studies the role of interaction between charged particles for transport and optical properties in nanostructures. Simulations are provided for a quantitative description of the system dynamics probed by either current spectroscopy or light absorption. In the first part of the thesis (Part I) the basic theories are described and in the second part of the thesis (Part II) the papers lis
BACKGROUND: During myocardial infarction reduced blood flow in the heart muscle results in cell death. These dying/dead cells have been reported to bind several plasma proteins such as IgM and C-reactive protein (CRP). In the present study we investigated whether fluid-phase complement inhibitor C4b-binding protein (C4BP) would also bind to the infarcted heart tissue. METHODS AND FINDINGS: Initial
Denna uppsats tar upp påstådda sovjetiska aktiva åtgärder och USA:s motåtgärder angående AIDS-desinformationskampanjen under 1980-talet, idag känd som operation “Denver”. Med användning av tidigare sekretessbelagda dokument från båda parter och myndighetsrapporter strävar vi efter att pröva teorier om aktiva åtgärder och inneslutningsstrategi. Arbetet har utgått från en kvalitativ innehållsanalys
Background: Mental health is a global public health issue. Mental health disorders can develop in anyone, but the prevalence is higher among refugees. Mental Health and Psychosocial Support (MHPSS), aims to improve mental health and is commonly applied among persons from conflict-afflicted settings such as, refugees. There are several studies demonstrating the effectiveness of MHPSS but there
This master’s thesis explores municipal and civil society refugee support practices in Berlin and Brandenburg, Germany during the current crisis of insecurity. Centering the question of how local-level support can oppose an excluding global precarization of refugees, the thesis works with an experiential puzzle to explore the subjective views of civil society and municipal actors in the realm of m
The purpose of this study is to investigate the consequences of Netflix’s latest policy change on consumers’ perceptions of the brand promise and on their willingness to continue using the service. Furthermore, we aim to explore the negative emotions that arose in response to the policy change.
Gal-3 appears clinically useful for ruling out short-term mortality in patients with acute dyspnea and could have role as a negative prognostic marker in the emergency department.
Background: Dyspnea is a common and diagnostically challenging symptom in the emergency department (ED), particularly among older adults with multimorbidity. Traditional risk stratification tools often perform poorly in this population. Galectin-3 (Gal-3), a biomarker of inflammation and fibrosis, may reflect biological aging and resilience, potentially improving early mortality risk assessment.Ob
Aims: Participation in exercise-based cardiac rehabilitation (exCR) increases aerobic capacity and improves outcomes in patients following myocardial infarction (MI) and is therefore universally recommended. While meta-Analyses consistently report that participation in exCR reduces cardiovascular mortality, there are conflicting results regarding effects on total mortality. Presently, many eligibl
