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We have used adult mouse superior cervical ganglia (SCG) to study the role of mitogen activated protein (MAP) kinase activity during axonal outgrowth in vitro. An initial peak in activity within the first hours of culture was followed by a substantially higher activity after 1 to 2 days, a time when axons were actively growing. The latter peak is probably a result of both higher levels of protein
Background: Recent evidence suggests a link between autoimmunity and the intestinal microbial composition in several rheumatic diseases including systemic sclerosis (SSc). The objective of this study was to investigate the prevalence of intestinal dysbiosis in SSc and to characterise patients suffering from this potentially immunomodulatory deviation. Methods: This study consisted of 98 consecutiv
Objectives: Ambulatory systolic-diastolic pressure regression index (ASDPRI) as a composite marker of cardiovascular (CV) properties is related to CV complications. However, genetic determinants of ASDPRI are not known. The aim of this study is to report the relationship between certain single nucleotide polymorphisms (SNP) and ASDPRI in hypertensive patients with CAD confirmed by coronary angiogr
Background: High-density Lipoprotein (HDL) attenuates endothelial cell apoptosis induced by different cell-death stimuli such as oxidation or growth factor deprivation. HDL is the main plasma carrier of the bioactive lipid sphingosine 1-phosphate (S1P), which it is a signaling molecule that promotes cell survival in response to several apoptotic stimuli. In HDL, S1P is bound to Apolipoprotein M (A
Objective: Our objective was to study the hypothalamic volume in a cohort of patients with amyotrophic lateral sclerosis (ALS) including symptomatic and presymptomatic ALS mutation carriers.Methods: High-resolution three-dimensional T1-weighted MRI datasets from 251 patients with sporadic ALS, 19 symptomatic and 32 presymptomatic ALS mutation carriers and 112 healthy controls (HC) were retrospecti
The smaller isoform of glutamate decarboxylase (GAD65) is a major autoantigen in type 1 diabetes (TID). Its hydrophobic character requires detergent to keep the protein in solution, which complicates studies of antigen processing and presentation. In this study an attempt was made to replace detergent with human serum albumin (HSA) for in vitro antigen presentation. Different preparations of recom
Associations between long-Term exposure to ambient air pollution and cognitive function have been observed in a few longitudinal studies. Our aim was to investigate the association between long-Term exposure to air pollution and episodic memory, a marker of early cognitive decline. We used data from the Betula study in Northern Sweden, and included participants 60 to 85 of age at inclusion, 1,469
Smart grids are often advertised as more environmentally sustainable compared to their “conventional” counterparts. What is highlighted then is their potential to save energy and integrate more renewables into the grid, thus decreasing CO2-emissions. This thesis investigates two less discussed aspects of smart grids, those of circular economy and social sustainability. An initial literature review
Corruption has been a widely discussed and analysed topic for decades. However, the results stemming from research on its effect are mixed and highly volatile, leading to a debate that it may be beneficial to the economy and society. The thesis puts this to a test with a focus on Europe during 2005-2019. By using rigorous testing, different proxies for corruption and subjective well-being, and var
This thesis is about the scope of protection for the right to strike. Despite the fundamental nature of the right in protecting the dignity of the worker and achieving social justice, the level of protection of the right to strike differs in different jurisdictions around the world claiming detrimental effects of strikes to the society and different stake-holders. Inspired by the longest rail work
This study emerges from the rising concern that the now widespread faith in renewable energy systems—as a way to deal with the ecological crisis—may be unfounded. Drawing on inspiration from the global peasant movement Via Campesina and their hypothesis that small-scale agriculture is a strategy for “cooling down the Earth”, this study seeks to discuss the reasons for the widespread belief in rene
Hainan province, as the only tropical region in China, suffered a housing bubble in the 1990s when the bubble burst. This was the first case of a bubble in the Chinese housing market. However, in the latest decade, Hainan housing market has become again heated up; the price of housing keeps increasing and new record housing prices have been reached. Is the housing bubble back again to this tropica
Thesis purpose: The purpose of this study is to analyze how platform and content intimacy affect customer engagement on TikTok and Instagram. Furthermore, it aims to investigate how different content categories (rational, interactional, and transactional) and modalities (video vs. photo) affect engagement levels on both platforms, if there is evidence of distinguished performances across TikTok an
The literature within Information Systems has approached Green IS from different perspectives and using different theoretical frameworks. The present paper analyzes the corre-lation between the existence of external pressures and Green IS adoption in the case of Swe-dish municipalities. A qualitative research was conducted, with the performance of in-depth interviews with representatives of a 4 Sw
For years researchers have studied retention and turnover, yet there is still no single solution for the problem of balancing both these concepts in organizations. Turnover is defined as the rupture of ties between an employee and his/her organization, whilst retention is defined as the option of the employee to stay in the organization while not looking out for other job alternatives. These two c
Matvaruhandeln på nätet växer och en stor del av matvaruinköpen online levereras med hemleverans. Den hemleveransmodell som idag används i störst utsträckning låter kunderna välja ett tidsfönster för när de vill ha sin leverans. Det innebär att rutterna måste anpassas efter olika tidsfönster, vilket resulterar i ineffektivitet och låg fyllnadsgrad i lastbilarna. Detta, i sin tur, gör att leveranseThe online market for groceries is continuously growing. Many of the online grocery purchases are home delivered, and the model that is currently the most commonly used allows the customer to pick a delivery time slot. This means that the delivery routes must be adapted according to time windows, which results in inefficient routes, a lot of half-empty vehicles, and hence in costly deliveries for
It is a universally acknowledged truth that the right to strike is one of the fundamentals of labour law. But what is it exactly? To what extent should it be protected and, thus, which limits are permissible?To find a unique answer to those questions is an uneasy task. In the contemporary multilevel legal framework the right to strike is regulated by a variety of provisions, moving from internatio
Background: There is a close association between non-alcoholic fatty liver disease (NAFLD) and prevalent chronic kidney disease (CKD). Few longitudinal studies exist. No previous study has investigated to what extent CKD affects mortality in biopsy-proven NAFLD. Our aim was to investigate the long-term risk of developing CKD in biopsy-prove
Acetophenone azine (AA) has recently been identified as a new allergen in shin pads and sports shoes. We report the case of a boy with allergic contact dermatitis of the shins caused by AA present in his shin pads. High-performance liquid chromatography of samples of shin pads was performed to help identify potential contact allergens. Patch tests revealed strongly positive reactions to pieces of
